Results 201 to 210 of about 57,792 (238)
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2000
The past few years have brought a flood of new information to the telomerase field. The identification of multiple components of both the telomere and telomerase, the understanding of the importance of telomere maintenance to the long term viability of cells, and the demonstration of the utility of telomerase inhibition in limiting tumor cell growth ...
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The past few years have brought a flood of new information to the telomerase field. The identification of multiple components of both the telomere and telomerase, the understanding of the importance of telomere maintenance to the long term viability of cells, and the demonstration of the utility of telomerase inhibition in limiting tumor cell growth ...
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TELOMERASE IN UROLOGICAL MALIGNANCY
The Journal of Urology, 2001Telomerase is a ribonucleoprotein enzyme that compensates for the progressive erosion of chromosomal ends, called telomeres. In most somatic cells telomerase expression is repressed and telomeres progressively shorten after each cell division, causing cell senescence.
ORLANDO, CLAUDIO +3 more
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Cold Spring Harbor Perspectives in Biology
Telomeres represent a molecular nexus where genome stability, aging, disease susceptibility, and regenerative potential converge. Advances in understanding how telomeres are replicated, protected, and repaired now inform fundamental questions about human lifespan, tissue renewal, the molecular origins of age-related decline, and cancer evolution.
Cooper, Julia Promisel +3 more
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Telomeres represent a molecular nexus where genome stability, aging, disease susceptibility, and regenerative potential converge. Advances in understanding how telomeres are replicated, protected, and repaired now inform fundamental questions about human lifespan, tissue renewal, the molecular origins of age-related decline, and cancer evolution.
Cooper, Julia Promisel +3 more
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Trends in Biochemical Sciences, 2003
Recent data indicates that controlled in vivo synthesis of telomeric DNA is a 'ménage à trois', in which sister chromatid termini paired by telomere end-binding protein constitute a core substrate for a telomerase dimer. Such an arrangement could serve to fine tune synthesis of telomeric DNA and might ensure similar telomerase processivity for paired ...
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Recent data indicates that controlled in vivo synthesis of telomeric DNA is a 'ménage à trois', in which sister chromatid termini paired by telomere end-binding protein constitute a core substrate for a telomerase dimer. Such an arrangement could serve to fine tune synthesis of telomeric DNA and might ensure similar telomerase processivity for paired ...
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Current Opinion in Genetics & Development, 1993
The ends of eukaryotic chromosomes are defined by specialized nucleoprotein complexes called telomeres. Telomeres impart stability to the genome and are of general interest due to their unique structure and unconventional mode of synthesis. Recent work has identified new components of the telomere complex and expanded our understanding of the role of ...
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The ends of eukaryotic chromosomes are defined by specialized nucleoprotein complexes called telomeres. Telomeres impart stability to the genome and are of general interest due to their unique structure and unconventional mode of synthesis. Recent work has identified new components of the telomere complex and expanded our understanding of the role of ...
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Telomeres, telomerase, and apoptosis
Biochemistry and Cell Biology, 2004Telomeres are specialized high-order chromatin structures that cap the ends of eukaryotic chromosomes. In vertebrates, telomeric DNA is composed of repetitions of the TTAGGG hexanucleotide, is bound to a set of specific proteins, and is elongated by the reverse transcriptase enzyme telomerase.
Mondello C, Scovassi AI
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Introduction to Telomeres and Telomerase
2011Telomeres are ends of chromosomes that play an important part in the biology of eukaryotic cells. Through the coordinated action of the telomerase and networks of other proteins and factors, the length and integrity of telomeres are maintained to prevent telomere dysfunction that has been linked to senescence, aging, diseases, and cancer. The tools and
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Regulation of human telomerase in homeostasis and disease
Nature Reviews Molecular Cell Biology, 2020Steven Artandi +2 more
exaly
Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe
Cell, 2018Simon Boulton +2 more
exaly