Results 151 to 160 of about 80,065 (270)

Chemical Diversity and Biological Significance of Sesquiterpene Lactones: From Biosynthesis to Anticancer Mechanisms

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Sesquiterpene lactones emerge as structurally diverse anticancer scaffolds with multifaceted mechanisms of action. Their biosynthesis, chemical diversity, structure–activity relationships, semisynthetic diversification, and molecular targets are integrated to highlight therapeutic opportunities and challenges.
Kedar Nimba Chaudhari, Ragini Yadav, Mayank Kashyap, Shreyans K. Jain   +3 more
wiley   +1 more source

Tracking telomerase

Cell, 2004
Blackburn, Elizabeth H., Greider, Carol W.   +1 more
openaire   +2 more sources

Telomerase [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2018
Andreas M, Beyer, Laura E, Norwood Toro
openaire   +2 more sources

The telomerase database

, 2008
Telomerase is a ribonucleoprotein enzyme that extends DNA at the chromosome ends in most eukaryotes. Since 1985, telomerase has been stud-ied intensively and components of the telomerase complex have been identified from over 160 eukary-otic species.
Rebecca V. Omana, Julian J. -l. Chen, Xiaodong Qi, Joshua D. Podlevsky, Christopher J. Bley   +4 more
core  

Characterization of the Interaction of Known G‐quadruplex Ligands With a Minimal i‐Motif Structure

Chemistry – A European Journal, Volume 32, Issue 37, 1 October 2026.
The destabilization of a minimal i‐Motif (iM) structure by TMPyP4 is driven by ligand recognition of one terminal iM structural domain. ABSTRACT Peculiar genomic regions are prone to evolve transiently from double‐helix DNA to noncanonical secondary structures in response to physiological stress.
Davide Auricchio, Marko Trajkovski, Janez Plavec, Claudia Sissi   +3 more
wiley   +1 more source

Fission yeast RPA-TERT-Tpz1TPP1 complex promotes telomere extension and suppresses telomere recombination. [PDF]

PLoS Genet
Moser BA, Points M, Agrawal S, Didier AC, Mennie AK, Lim CJ, Xu YJ, Nakamura TM.   +7 more
europepmc   +1 more source

Improved Method for Obtaining Patient‐Derived Glioblastoma Organoid and Primary Cells: A Generic and Simplified Approach for Intracranial Tumor With Minimized Input

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
An improved and simplified method enables the generation of primary tumor cells and tumoroids from the same tissue sample with minimal input, applicable universally to both intracranial and spinal tumors. Comparative analysis of drug screening results with patient follow‐up data allows for the assessment of individual drug sensitivity.
Siyuan Wang, Zhonggang Shi, Chihao Zhu, Dawei Dai, Xi Yang, Zhiyi Zhou, Qianying Qiu, Wenhua Sun, Yifeng Miao, Yongming Qiu   +9 more
wiley   +1 more source

The Different Faces of the Selective Human Telomerase Inhibitor: BIBR1532 and Its Derivatives. [PDF]

Curr Issues Mol Biol
Kosno M, Maciejewska N, Wolska K, Gabriel I.   +3 more
europepmc   +1 more source

Bladerunners and telomerases [PDF]

European Journal of Endocrinology, 1999
openaire   +2 more sources

Integrating Multimodal MRI Habitat and Transformer‐Based Pathomics to Predict High‐Risk Molecular Subtypes and Explore Biological Mechanisms in Adult Diffuse Gliomas

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Based on the 2021 WHO CNS5 guidelines, this study introduces an integrated high‐risk molecular classification for gliomas and constructs a predictive model by combining multimodal MRI habitat imaging, Transformer‐based WSI pathomics, and clinical information.
Wenju Niu, Xin Duan, Xuan Li, Zehui Li, Qian Liang, Xiangli Yang, Yan Tan, Xiaochun Wang, Guoqiang Yang, Hui Zhang   +9 more
wiley   +1 more source