Results 121 to 130 of about 72,827 (301)

Variations in telomere maintenance and the role of telomerase inhibition in gastrointestinal cancer

, 2015
Steffen Heeg Department of Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases, Medical Center – University of Freiburg, Freiburg, Germany Abstract: Immortalization is an important step toward the malignant ...
Heeg S, Heeg, Steffen
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Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

An Alternate Splicing Variant of the Human Telomerase Catalytic Subunit Inhibits Telomerase Activity

Neoplasia: An International Journal for Oncology Research, 2000
Telomerase, a cellular reverse transcriptase, adds telomeric repeats to chromosome ends. In normal human somatic cells, telomerase is repressed and telomeres progressively shorten, leading to proliferative senescence.
Xiaoming Yi, Dennis M. White, Dara L. Aisner, Joseph A. Baur, Woodring E. Wright, Jerry W. Shay   +5 more
doaj   +1 more source

Clinical Significance of Telomerase Activity and Telomere Length in Various Liver Diseases [PDF]

, 2003
We investigated the clinical significance of telomerase activity and telomere length in hepatocellular carcinomas (HCCs) and chronic liver diseases. Telomerase activity was assessed quantitatively using 'Stretch PCR' assay and telomere length by Southern
Fujioka, Hikaru, Okudaira, Sadayuki, Kitaoka, Fumio, Furui, Junichiro, Takayama, Kazuyuki, Kanematsu, Takashi   +5 more
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Telomeres and telomerase in the clinical management of colorectal cancer

, 2017
Colorectal cancer (CRC) is the third most common cancer worldwide. Our aim is to describe the state of the art about the role of telomeres and telomerase in the clinical management of CRC and its potential utility as prognostic and diagnostic biomarkers ...
Viñas-Salas, J., Valls-Bautista, C., Piñol-Felis, C., Fernández Marcelo, Tamara   +3 more
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Telomerase Is Essential for Zebrafish Heart Regeneration. [PDF]

, 2015
After myocardial infarction in humans, lost cardiomyocytes are replaced by an irreversible fibrotic scar. In contrast, zebrafish hearts efficiently regenerate after injury.
Gomez, Manuel J, Gutiérrez Gutiérrez, Óscar, González-Rosa, Juan Manuel, Cortés, Alfonso, dos Santos Marques, Ines Joao, Cortés Rubio, José Alfonso, Alfonso Cortés, Agustín Zapata, Jimenez-Borreguero, Luis J., Irene de Diego, Manuel José Gómez, González Rosa, Juan Manuel, Marques, Inês João, Guzmán Martínez, Gabriela, de Diego, Irene, Luis Jesús Jiménez-Borreguero, Aguado, Tania, Carlota Sánchez-Ferrer, Joao Marques, Ines, Diego, Irene de, Bednarek, Dorota, Mercader Huber, Nadia, Galardi Castilla, María, Guzmán-Martínez, Gabriela, Sánchez-Ferrer, Carlota, María Galardi-Castilla, Gómez, Manuel José, Zapata González, Agustín, Flores, Ignacio, Jiménez Borreguero, Luis Jesús, Jiménez-Borreguero, Luis Jesús, Ignacio Flores, Sánchez Ferrer, Carlota, Zapata, Agustín, Mercader, Nadia, Galardi-Castilla, María, Óscar Gutiérrez-Gutiérrez, Nadia Mercader, Juan Manuel González-Rosa, Dorota Bednarek, Inês João Marques, Tania Aguado, Gutiérrez-Gutiérrez, Óscar, Gabriela Guzmán-Martínez   +43 more
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Evolving Pathology of Anaplastic Thyroid Carcinoma: Integrating Morphology, Immunohistochemistry, and Molecular Insights

Cancer Science, EarlyView.
Schematic overview of progression from differentiated thyroid carcinoma (DTC) to anaplastic thyroid carcinoma (ATC). ATC primarily develops via two pathways: the BRAF p.V600E‐mutated papillary thyroid carcinoma (PTC) pathway and the RAS‐mutated pathway. The origin and progression of BRAF/RAS‐wildtype ATC remain unclear.
Toru Odate, Tetsuo Kondo
wiley   +1 more source

The role of telomere and telomerase in cancer and novel therapeutic target: narrative review

Frontiers in Oncology
Telomeres are dynamic complexes at the ends of chromosomes that are made up of protective proteins and tandem repeating DNA sequences. In the large majority of cancer cells, telomere length is maintained by telomerase, an enzyme that elongates telomeres.
Temesgen Baylie, Mohammed Jemal, Gelagay Baye, Mamaru Getinet, Gashaw Azanaw Amare, Adane Adugna, Desalegn Abebaw, Zigale Hibstu, Bantayehu Addis Tegegne, Endalkachew Gugsa, Tadegew Adane, Gedefaw Getie, Baye Ashenef, Deresse Sinamaw   +13 more
doaj   +1 more source

Therapeutic inhibition of TRF1 impairs the growth of p53‐deficient K‐RasG12V‐induced lung cancer by induction of telomeric DNA damage

EMBO Molecular Medicine, 2015
Telomeres are considered anti‐cancer targets, as telomere maintenance above a minimum length is necessary for cancer growth. Telomerase abrogation in cancer‐prone mouse models, however, only decreased tumor growth after several mouse generations when ...
María García‐Beccaria, Paula Martínez, Marinela Méndez‐Pertuz, Sonia Martínez, Carmen Blanco‐Aparicio, Marta Cañamero, Francisca Mulero, Chiara Ambrogio, Juana M Flores, Diego Megias, Mariano Barbacid, Joaquín Pastor, Maria A Blasco   +12 more
doaj   +1 more source

Differences in Disease Severity but Similar Telomere Lengths in Genetic Subgroups of Patients with Telomerase and Shelterin Mutations

, 2011
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Anna Ratcliffe, Tom J Vulliamy, Vulliamy Tom J., Kirwan, MJ, Hossain, U, Ratcliffe Anna, Vulliamy, Tom J., Baqai Charlotte, Kirwan Michael J., Baqai, Charlotte, Michael J. Kirwan, Baqai, C, Ratcliffe, A, Beswick, Richard, Marsh, Judith, Walne, Amanda, Beswick, R, Inderjeet Dokal, Dokal, Inderjeet, Walne Amanda, Kirwan, Michael J., Marsh, J, Charlotte Baqai, Judith Marsh, Marsh Judith, Tom J. Vulliamy, Beswick Richard, Dokal, I, Hossain, Upal, Vulliamy, TJ, Upal Hossain, Amanda Walne, Dokal Inderjeet, Richard Beswick, Michael J Kirwan, Ratcliffe, Anna, Hossain Upal, Walne, A   +37 more
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