Results 21 to 30 of about 80,065 (270)
There is no correlation between c-Myc mRNA expression and telomerase activity in human breast cancer [PDF]
, 2004 Background Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal length and stability thus leading to cellular immortalisation.
Kefah Mokbel +5 more
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Cycloastragenol Attenuates Cisplatin-Induced Ovarian Toxicity in Rats: Associations With TERT Expression, Apoptotic Balance, and FOXO3a-mTOR-Related Signaling. [PDF]
J Biochem Mol ToxicolCycloastragenol partially attenuated cisplatin‐induced ovarian toxicity and was associated with partial preservation of follicular morphology, improvement in apoptotic balance, and changes in FOXO3a–mTOR‐related markers and ovarian TERT expression. ABSTRACT Cisplatin (CIS)‐induced ovarian toxicity is characterized by follicular depletion, apoptosis ...
Erol GNA, Yar AS, Kaplanoğlu GT.
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Telomerase activity in melanoma and non-melanoma skin cancer [PDF]
, 1998 Telomeres are specialized structures consisting of repeat arrays of TTAGGGn located at the ends of chromosomes. They are essential for chromosome stability and, in the majority of normal somatic cells, telomeres shorten with each cell division.
MacGregor, J +11 more
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Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2012 The intimate connection between telomerase regulation and human disease is now well established. The molecular basis for telomerase regulation is highly complex and entails multiple layers of control. While the major target of enzyme regulation is the catalytic subunit TERT, the RNA subunit of telomerase is also implicated in telomerase control.
Catherine, Cifuentes-Rojas +1 more
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Current Opinion in Structural Biology, 2014 The telomerase reverse transcriptase has an essential role in telomere maintenance and in cancer biology. Progress during the last year has revealed the three-dimensional architecture of both human and ciliate telomerase at about 25Å resolution, obtained using single particle electron microscopy (EM).
Sandin, Sara, Rhodes, Daniela
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Canonical and extra‐telomeric functions of telomerase: Implications for healthy ageing conferred by endurance training [PDF]
, 2023 Telomerase preserves genomic integrity by maintaining and protecting the telomeres. Seminal findings from 1985 revealed the canonical role of telomerase and motivated investigations into potential therapeutic strategies to combat one of the hallmarks of ...
Joshua Denham, Denham, Josh
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Telomerase Is Processive [PDF]
Molecular and Cellular Biology, 1991 Telomerase synthesizes tandem repeats of the sequence d(TTGGGG) onto input d(TTGGGG)n primer oligonucleotides (C. W. Greider and E. H. Blackburn, Cell 43:405-413). An intrinsic RNA component of the enzyme provides the template for d(TTGGGG)n repeat synthesis [C. W. Greider and E. H. Blackburn, Nature (London) 337:331-337, 1989; G.-L. Lu, J. D. Bradley,
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Reproduction, 2010 Abstract Telomerase, an enzyme complex that binds the chromosome ends (telomeres) and maintains telomere length and integrity, is present in germ cells, proliferative granulosa cells, germline stem cells, and neoplastic cells in the ovary, but it is absent in differentiated or aged cells.
Jun-Ping, Liu, He, Li
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Mice with hyper-long telomeres show less metabolic aging and longer lifespans
Nature Communications, 2019 Telomere shortening is associated with aging. Here the authors analyze mice with hyperlong telomeres and demonstrate that longer telomeres than normal have beneficial effects such as delayed metabolic aging, increased longevity and less incidence of ...
Miguel A. Muñoz-Lorente +2 more
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F1000Research, 2016 Telomeres, the protective ends of linear chromosomes, shorten throughout an individual’s lifetime. Telomere shortening is a hallmark of molecular aging and is associated with premature appearance of diseases associated with aging.
Christian Bär, Maria A. Blasco
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