Results 21 to 30 of about 72,827 (301)
Telomerase activity in melanoma and non-melanoma skin cancer [PDF]
, 1998 Telomeres are specialized structures consisting of repeat arrays of TTAGGGn located at the ends of chromosomes. They are essential for chromosome stability and, in the majority of normal somatic cells, telomeres shorten with each cell division.
MacGregor, J +11 more
core +1 more source
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
Telomerase is not an oncogene [PDF]
Oncogene, 2002 In the decade since the telomere hypothesis of cellular aging was proposed, the two essential genes for human telomerase were cloned and characterized, allowing experimental proof of the causal relationships between telomere loss and replicative senescence, and telomerase activation and immortalization.
openaire +2 more sources
Nature Communications, 2016 Telomere shortening has been linked to some aspects of organismal ageing. Here the authors create chimaeric mice that contain a mix of cells with normal or unnaturally long telomeres, and show chimaeric mice are protected from some forms of ageing ...
Elisa Varela +4 more
doaj +1 more source
Sox4 Links Tumor Suppression to Accelerated Aging in Mice by Modulating Stem Cell Activation
Cell Reports, 2014 Sox4 expression is restricted in mammals to embryonic structures and some adult tissues, such as lymphoid organs, pancreas, intestine, and skin. During embryogenesis, Sox4 regulates mesenchymal and neural progenitor survival, as well as lymphocyte and ...
Miguel Foronda +7 more
doaj +1 more source
Molecular Oncology, 2023 Telomerase activation is required for malignant transformation. Recent advances in high‐throughput technologies have enabled the generation of complex datasets, thus providing alternative approaches to exploring telomerase biology more comprehensively ...
Jing Wang +8 more
doaj +1 more source
Canonical and extra‐telomeric functions of telomerase: Implications for healthy ageing conferred by endurance training [PDF]
, 2023 Telomerase preserves genomic integrity by maintaining and protecting the telomeres. Seminal findings from 1985 revealed the canonical role of telomerase and motivated investigations into potential therapeutic strategies to combat one of the hallmarks of ...
Joshua Denham, Denham, Josh
core +1 more source
Telomere erosion in memory T cells induced by telomerase inhibition at the site of antigenic challenge in vivo. [PDF]
, 2004 The extent of human memory T cell proliferation, differentiation, and telomere erosion that occurs after a single episode of immune challenge in vivo is unclear.
Beverley, PCL +31 more
core +1 more source
Mice with hyper-long telomeres show less metabolic aging and longer lifespans
Nature Communications, 2019 Telomere shortening is associated with aging. Here the authors analyze mice with hyperlong telomeres and demonstrate that longer telomeres than normal have beneficial effects such as delayed metabolic aging, increased longevity and less incidence of ...
Miguel A. Muñoz-Lorente +2 more
doaj +1 more source
F1000Research, 2016 Telomeres, the protective ends of linear chromosomes, shorten throughout an individual’s lifetime. Telomere shortening is a hallmark of molecular aging and is associated with premature appearance of diseases associated with aging.
Christian Bär, Maria A. Blasco
doaj +1 more source