Results 11 to 20 of about 80,065 (270)

Is telomerase reactivation associated with the down-regulation of TGF β receptor-II expression in human breast cancer? [PDF]

Cancer Cell International, 2003
Background Telomerase is a ribonucleoprotein that synthesizes telomeres and plays an important role in chromosomal stability and cellular immortalisation. Telomerase activity is detectable in most human cancers but not in normal somatic cells.
Thomas Valene, Newbold Robert F, Elkak Abd E, Mokbel Kefah   +3 more
doaj   +2 more sources

Functional identification and mapping of a gene that represses telomerase hTERT transcription in prostate cancer cells [PDF]

, 2010
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Telomerase is present in over 90% of tumour tissues and immortalized cells and is tightly regulated in most normal somatic cells.
Hasan, Rana
core   +7 more sources

The role of the cell attachment in the regulation of telomerase during keratinocyte differentiation [PDF]

, 2010
PhDThe catalytic subunit of telomerase TERT has non-canonical functions, which are independent of telomere elongation and sometimes telomerase activity.
Cereser, Biancastella
core   +4 more sources

Telomerase Unplugged [PDF]

ACS Chemical Biology, 2007
The control of telomerase activity at chromosome ends by telomere-binding proteins is critical for telomere length homeostasis. Two recent papers identify TPP1 as a critical mediator of this control. TPP1 forms part of the telomeric shelterin complex while also associating with telomerase, stimulating its activity and processivity.
Cristofari, G., Sikora, K., Lingner, J.
openaire   +3 more sources

The Telomerase Database [PDF]

Nucleic Acids Research, 2007
Telomerase is a ribonucleoprotein enzyme that extends DNA at the chromosome ends in most eukaryotes. Since 1985, telomerase has been studied intensively and components of the telomerase complex have been identified from over 160 eukaryotic species. In the last two decades, there has been a growing interest in studying telomerase owing to its vital role
Joshua D. Podlevsky, Christopher J. Bley, Rebecca V. Omana, Xiaodong Qi, Julian J.-L. Chen   +4 more
openaire   +3 more sources

Telomeres and telomerase [PDF]

Genes & Development, 1999
Telomeres are in the spotlight of modern biology. Whether the subject at hand is cancer, gene regulation, organismal aging, or the cloning of mammals, much seems to depend on what happens at the ends of chromosomes. Because glamorous hypotheses often persist without experimental support, it is important to ask ourselves what we really know about ...
Blasco, M. A., Gasser, S. M., Lingner, J.   +2 more
openaire   +2 more sources

Dynamic telomerase gene suppression via network effects of GSK3 inhibition [PDF]

, 2009
<b>Background</b>: Telomerase controls telomere homeostasis and cell immortality and is a promising anti-cancer target, but few small molecule telomerase inhibitors have been developed. Reactivated transcription of the catalytic subunit hTERT
Jon Roffey, Alan E Bilsland, Natividad Gomez-Roman, Gomez-Roman, Natividad, Plumb, Jane, Bilsland, A.E., Bilsland, Alan E., W Nicol Keith, Hammonds, T., Katrina Stevenson, Claire Cairney, Gomez-Roman Natividad, Cairney Claire, Hoare, S.F., Hammonds, Tim, Sharon Burns, Cairney, C.J., Lafferty-Whyte, Kyle, Hammonds Tim, Burns, S., Roffey Jon, Plumb Jane, Plumb, J.A., Roffey, Jon, Keith, W. Nicol, Cairney, Claire, Burns Sharon, Jane Plumb, Stevenson Katrina, Keith W. Nicol, Keith, W.N., Hoare, Stacey, Bilsland Alan E., Kyle Lafferty-Whyte, Gomez-Roman, N., Stacey Hoare, Hoare Stacey, Stevenson, K.H., Stevenson, Katrina, Burns, Sharon, Lafferty-Whyte, K., Lafferty-Whyte Kyle, Tim Hammonds   +42 more
core   +2 more sources

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Hepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate‐Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara   +29 more
wiley   +1 more source

Telomeres and telomerase [PDF]

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2004
Telomeres are the protective DNA–protein complexes found at the ends of eukaryotic chromosomes. Telomeric DNA consists of tandem repeats of a simple, often G–rich, sequence specified by the action of telomerase, and complete replication of telomeric DNA requires telomerase.
Simon R W L, Chan, Elizabeth H, Blackburn   +1 more
openaire   +2 more sources

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source