Results 41 to 50 of about 59,573 (233)

Maintaining telomere length

Postępy Higieny i Medycyny Doświadczalnej, 2013
Telomeres protect the ends of chromosomes maintaining genome stability. The activity of telomerase enzyme, or alternatively the process of recombination, regulates the length of telomeres. In the absence of these mechanisms, excessive shortening of telomeres reach its critical level.
openaire   +2 more sources

Concordance and Disconcordance of Serum Levels of Leptin with Leucocyte Telomere Length Across Spectrum of Adult Body Mass Index Among Indian Rural Population

Clinical and Research Journal in Internal Medicine, 2023
Background: Obesity is a prominent avoidable cause of mortality and a growing health concern in both adults and children throughout the world. The study's goal is to measure leucocyte telomere length and its relationship with leptin throughout the BMI ...
Anurag Yadav, L G Nandakumar, Anmol Manaswini Golla Yadav, Srivats Golla Yadav, Kaveri N Karewad   +4 more
doaj   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Association Between Riboflavin Intake and Telomere Length: A Cross-Sectional Study From National Health and Nutrition Examination Survey 1999–2002

Frontiers in Nutrition, 2022
BackgroundDietary habits and dietary intake affect telomere length, a reliable marker of biological aging and a predictor of chronic disease. Riboflavin (RF) is known as a water-soluble antioxidant vitamin, but its role in telomere length maintenance has
Weihua Chen, Weihua Chen, Shanshan Shi, Shanshan Shi, Yizhou Jiang, Liling Chen, Ying Liao, Kaihong Chen, Kun Huang   +8 more
doaj   +1 more source

SETD1A Regulates Glycolysis and Senescence of Nucleus Pulposus Cells via H3K4me3–HELZ2/PPARα‐HIF1α Axis to Drive Intervertebral Disc Degeneration

Advanced Science, EarlyView.
SETD1A is a key epigenetic regulator in NPCs during IDD. In normal NPCs, it sustains H3K4me3–HELZ2/PPARα–HIF1α signaling to maintain glycolytic energy metabolism and proliferation. In degenerated NPCs, reduced SETD1A disrupts this axis, impairing glycolysis and accelerating senescence, highlighting a promising therapeutic target for IDD.
Jiawei Fu, Xue Leng, Jiang Long, Zhengao Liao, Xiaoqin An, Xuezheng Ai, Dan Long, Changqing Li, Bo Huang, Yue Zhou, Shiwu Dong, Chencheng Feng   +11 more
wiley   +1 more source

Telomere Length: Implications for Atherogenesis

Current Atherosclerosis Reports, 2023
Abstract Purpose of Review The purpose of the study is to explore the evidence linking telomere length with atherosclerotic ischemic disease. Recent Findings There has been a recent expansion in strategies for measuring telomere length, including analyzing genome sequence ...
Hao Yin, J. Geoffrey Pickering
openaire   +2 more sources

NONO, SFPQ, and PSPC1 promote telomerase recruitment to the telomere

Nature Communications
Telomerase is a ribonucleoprotein enzyme that maintains telomeric repeats on chromosome ends in continuously dividing cells. Telomere maintenance via telomerase is dependent on the correct assembly of the enzyme complex, complex stabilization by ...
Alexander P. Sobinoff, Jadon K. Wells, Maurice Chow, Christopher B. Nelson, Xinyi Wu, Scott B. Cohen, Yu Heng Lau, Tracy M. Bryan, Archa Fox, Hilda A. Pickett   +9 more
doaj   +1 more source

Association between lipoproteins and telomere length in US adults: data from the NHANES 1999–2002

Lipids in Health and Disease, 2019
Background Evidence regarding the correlation between lipoproteins and telomere length in US adults is limited. We aimed to investigate whether lipoproteins was associated with telomere length using US National Health and Nutrition Examination Survey ...
Yun-Fen Chen, Kai-Wen Zhou, Gui-zhen Yang, Chi Chen   +3 more
doaj   +1 more source

Mechanically Triggered DNA Nanovehicles for Targeted Dual‐Drug Cancer Therapy

Advanced Science, EarlyView.
A mechanically triggered DNA nanovehicle is introduced that co‐releases two anticancer drugs in response to integrin‐mediated cellular forces. Cholesterol‐anchored DNA assemblies undergo force‐induced unfolding at cell–cell junctions, enabling selective, localized dual‐drug activation in cancer cells while minimizing off‐target toxicity in low‐tension ...
Murali Mohana Rao Singuru, Priyanka Bhattacharyya, Mingxu You   +2 more
wiley   +1 more source

Correlation of telomere length in brain tissue with peripheral tissues in living human subjects

Frontiers in Molecular Neuroscience
Telomeres are important to chromosomal stability, and changes in their length correlate with disease, potentially relevant to brain disorders. Assessing telomere length in human brain is invasive, but whether peripheral tissue telomere length correlates ...
Annemarie J. Carver, Annemarie J. Carver, Annemarie J. Carver, Benjamin Hing, Benjamin Hing, Benjamin A. Elser, Benjamin A. Elser, Benjamin A. Elser, Stephanie J. Lussier, Stephanie J. Lussier, Stephanie J. Lussier, Takehiko Yamanashi, Takehiko Yamanashi, Takehiko Yamanashi, Takehiko Yamanashi, Matthew A. Howard, Matthew A. Howard, Hiroto Kawasaki, Hiroto Kawasaki, Gen Shinozaki, Gen Shinozaki, Gen Shinozaki, Hanna E. Stevens, Hanna E. Stevens, Hanna E. Stevens, Hanna E. Stevens, Hanna E. Stevens   +26 more
doaj   +1 more source