Results 41 to 50 of about 62,113 (243)

TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT

EMBO Molecular Medicine, 2022
In some types of cancer, telomere length is maintained by the alternative lengthening of telomeres (ALT) mechanism. In many ALT cancers, the α‐thalassemia/mental retardation syndrome X‐linked (ATRX) gene is mutated leading to the conclusion that the ATRX
Alexandre de Nonneville, Sébastien Salas, François Bertucci, Alexander P Sobinoff, José Adélaïde, Arnaud Guille, Pascal Finetti, Jane R Noble, Dimitri Churikov, Max Chaffanet, Elise Lavit, Hilda A Pickett, Corinne Bouvier, Daniel Birnbaum, Roger R Reddel, Vincent Géli   +15 more
doaj   +1 more source

Association Between Riboflavin Intake and Telomere Length: A Cross-Sectional Study From National Health and Nutrition Examination Survey 1999–2002

Frontiers in Nutrition, 2022
BackgroundDietary habits and dietary intake affect telomere length, a reliable marker of biological aging and a predictor of chronic disease. Riboflavin (RF) is known as a water-soluble antioxidant vitamin, but its role in telomere length maintenance has
Weihua Chen, Weihua Chen, Shanshan Shi, Shanshan Shi, Yizhou Jiang, Liling Chen, Ying Liao, Kaihong Chen, Kun Huang   +8 more
doaj   +1 more source

Telomere length and risk of glioma [PDF]

Cancer Epidemiology, 2013
Telomere length in blood or buccal cell DNA has been associated with risk of various cancers. Glioma can be a highly malignant brain tumor and has few known risk factors. Genetic variants in or near RTEL1 and TERT, key components of telomere biology, are associated with glioma risk.
Farzana, Walcott, Preetha, Rajaraman, Shahinaz M, Gadalla, Peter D, Inskip, Mark P, Purdue, Demetrius, Albanes, Esther, Orr, Immaculata, De Vivo, Sharon A, Savage   +8 more
openaire   +2 more sources

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali, Priyanka Menon, Halil I. Corbali, Ram Jagannathan, Allan I. Levey   +4 more
wiley   +1 more source

Concordance and Disconcordance of Serum Levels of Leptin with Leucocyte Telomere Length Across Spectrum of Adult Body Mass Index Among Indian Rural Population

Clinical and Research Journal in Internal Medicine, 2023
Background: Obesity is a prominent avoidable cause of mortality and a growing health concern in both adults and children throughout the world. The study's goal is to measure leucocyte telomere length and its relationship with leptin throughout the BMI ...
Anurag Yadav, L G Nandakumar, Anmol Manaswini Golla Yadav, Srivats Golla Yadav, Kaveri N Karewad   +4 more
doaj   +1 more source

Telomere length and cardiovascular aging

Annals of Medicine, 2012
Telomeres are located at the end of chromosomes. They are composed of repetitive TTAGGG tandem repeats and associated proteins of crucial importance for telomere function. Telomeric DNA is shortened by each cell division until a critical length is achieved and the cell enters senescence and eventually apoptosis.
Frej, Fyhrquist, Outi, Saijonmaa
openaire   +2 more sources

Chemical Screening Identifies Danofloxacin as a Self‐Renewal Agonist of Embryonic Stem Cells through Alleviation of HDAC1‐Mediated Deacetylation of Tert and Prdm10

Advanced Science, EarlyView.
This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Yan Zhang, Junxiang Ji, Baoxing Dong, Zhenhua Zhu, Xucheng Lv, Peng Chen, Wenqiang Liu, Min Zhou, Shou‐Dong Ye   +8 more
wiley   +1 more source

NONO, SFPQ, and PSPC1 promote telomerase recruitment to the telomere

Nature Communications
Telomerase is a ribonucleoprotein enzyme that maintains telomeric repeats on chromosome ends in continuously dividing cells. Telomere maintenance via telomerase is dependent on the correct assembly of the enzyme complex, complex stabilization by ...
Alexander P. Sobinoff, Jadon K. Wells, Maurice Chow, Christopher B. Nelson, Xinyi Wu, Scott B. Cohen, Yu Heng Lau, Tracy M. Bryan, Archa Fox, Hilda A. Pickett   +9 more
doaj   +1 more source

Longer telomere length in COPD patients with α1-antitrypsin deficiency independent of lung function.

PLoS ONE, 2014
Oxidative stress is involved in the pathogenesis of airway obstruction in α1-antitrypsin deficient patients. This may result in a shortening of telomere length, resulting in cellular senescence.
Aabida Saferali, Jee Lee, Don D Sin, Farshid N Rouhani, Mark L Brantly, Andrew J Sandford   +5 more
doaj   +1 more source

RNAi in the Rhizarian Phytopathogen Plasmodiophora brassicae: The Causal Agent of Clubroot Disease in Cruciferous Crops

Advanced Science, EarlyView.
This study uncovers an unusual RNAi pathway in the rhizarian pathogen Plasmodiophora brassicae. In the absence of Dicer, a Drosha‐like RNase III protein supports the biogenesis of predominant 21‐nt small RNAs, and two Argonaute proteins mediate small RNA‐guided silencing.
Xiong Zhang, Yupo Wu, Jiachang Hou, Lixia Gao, Longqi Pan, Cuicui Shen, Chuanji Zhao, Feng Gao, Yi Zhang, Li Ren, Xiaoping Fang, Xiaoling Dun, Shengyi Liu, Lijiang Liu   +13 more
wiley   +1 more source