Results 61 to 70 of about 59,573 (233)

Is telomere length associated with mate choice in a songbird with a high rate of extra-pair paternity? [PDF]

PLoS ONE, 2017
Telomere length is related to aging in many eukaryotes and the rate of telomere attrition has been suggested to reflect individual genetic quality. Telomere length could thus have implications for mate choice. We investigated telomere length variation in
Arild Johnsen, Angela Pauliny, Jan T Lifjeld, Donald Blomqvist   +3 more
doaj   +1 more source

AI Powered Biobanks From Static Archives to Dynamic Discovery Engines

Advanced Intelligent Discovery, EarlyView.
Large language models (LLMs) provide a potential framework for transforming biobanks from static data repositories into intelligent discovery engines. By enabling unified representation and analysis of multimodal biomedical data, LLM‐based systems facilitate dynamic risk prediction, biomarker identification, and mechanistic interpretation, thereby ...
Wenzhen Yin, Yutian Feng, Wenrui Ma, Yuxin Su, Li Min, Juan Liu   +5 more
wiley   +1 more source

De Novo Complex Genomic Rearrangement Spanning 2q31.1 in a Proband With Congenital Malformations: Genotype–Phenotype Correlation and Development of a CGR Detection Pipeline

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The 2q31 region is commonly associated with pathogenic alleles of the HOXD cluster leading to various clinical phenotypes related to skeletal development. We present a proband with tetralogy of Fallot and multiple congenital anomalies. Genomic variant screening including an in‐house CGR detection pipeline pairing genome sequencing (GS ...
Katherine Helle, Jesse D. Bengtsson, Mira Gandhi, Christopher M. Grochowski, Ming Yin Lun, Neha Sudhir, Shalini N. Jhangiani, Fritz J. Sedlazeck, Seema R. Lalani, Neil A. Hanchard, Claudia M. B. Carvalho   +10 more
wiley   +1 more source

Telomere G-tail Length is a Promising Biomarker Related to White Matter Lesions and Endothelial Dysfunction in Patients With Cardiovascular Risk: A Cross-sectional Study

EBioMedicine, 2015
Background: The telomeric 3′-overhang (G-tail) length is essential for the biological effects of telomere dysfunction in vitro, but the association of length with aging and cardiovascular risk is unclear in humans. We investigated the association between
Tomohisa Nezu, Naohisa Hosomi, Tetsuya Takahashi, Kumiko Anno, Shiro Aoki, Akira Shimamoto, Hirofumi Maruyama, Tomonori Hayashi, Masayasu Matsumoto, Hidetoshi Tahara   +9 more
doaj   +1 more source

Short telomeres initiate telomere recombination in primary and tumor cells. [PDF]

PLoS Genetics, 2009
Human tumors that lack telomerase maintain telomeres by alternative lengthening mechanisms. Tumors can also form in telomerase-deficient mice; however, the genetic mechanism responsible for tumor growth without telomerase is unknown.
Tammy A Morrish, Carol W Greider
doaj   +1 more source

Reduction of Ribonucleotide Reductase Subunit RRM2 Potentially Impairs Gut Function of Woody Breast Broilers

Animal Research and One Health, EarlyView.
Woody breast compromises meat quality leading to reduced consumer appeal. Although its causes are unclear, improvements observed with certain dietary supplements suggest that gut health may influence woody breast development. Ribonucleotide reductase subunit RRM2 is vital for mitochondrial function and gastrointestinal integrity, and alteration in its ...
Majid Shakeri, Elizabeth Ziabtchenko, Janghan Choi, Caitlin E. Harris, Richard J. Buhr, Trevor R. Mitchell, Byungwhi Kong, Hong Zhuang, Brian Bowker   +8 more
wiley   +1 more source

Gravidity is not associated with telomere length in a biracial cohort of middle-aged women: The Coronary Artery Risk Development in Young Adults (CARDIA) study. [PDF]

PLoS ONE, 2017
OBJECTIVE:Having experienced 2-3 births is associated with reduced mortality versus women with
Abbi D Lane-Cordova, Eli Puterman, Erica P Gunderson, Cheeling Chan, Lifang Hou, Mercedes Carnethon   +5 more
doaj   +1 more source

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere length. [PDF]

PLoS ONE, 2012
Telomeres, specialised structures that protect chromosome ends, play a critical role in preserving chromosome integrity. Telomere dynamics in the Tasmanian devil (Sarcophilus harrisii) are of particular interest in light of the emergence of devil facial ...
Hannah S Bender, Elizabeth P Murchison, Hilda A Pickett, Janine E Deakin, Margaret A Strong, Carly Conlan, Daniel A McMillan, Axel A Neumann, Carol W Greider, Gregory J Hannon, Roger R Reddel, Jennifer A Marshall Graves   +11 more
doaj   +1 more source

Oocyte–cumulus cell interaction: a key factor in early embryo development

Biological Reviews, EarlyView.
ABSTRACT The evaluation of oocyte competence is a fundamental step in achieving successful outcomes following assisted reproduction techniques (ART). At present, however, conventional oocyte maturation assessment is carried out by morphological observation, which is a subjective method that does not consider molecular features.
Marc Torres‐Garrido, Marc Yeste, Yentel Mateo‐Otero   +2 more
wiley   +1 more source