Results 61 to 70 of about 2,052,365 (293)

Telomere length and risk of glioma [PDF]

Cancer Epidemiology, 2013
Telomere length in blood or buccal cell DNA has been associated with risk of various cancers. Glioma can be a highly malignant brain tumor and has few known risk factors. Genetic variants in or near RTEL1 and TERT, key components of telomere biology, are associated with glioma risk.
Farzana, Walcott, Preetha, Rajaraman, Shahinaz M, Gadalla, Peter D, Inskip, Mark P, Purdue, Demetrius, Albanes, Esther, Orr, Immaculata, De Vivo, Sharon A, Savage   +8 more
openaire   +2 more sources

AI‐Assisted Digital Single‐Molecule Activity Tracker for Decoupling Intrinsic Heterogeneity from Photo‐Oxidative Damage in High‐Photon‐Flux Enzymology

Advanced Science, EarlyView.
Employing a digital single‐molecule activity tracker (dSMAT), this research demonstrates that high‐photon‐flux irradiation drives progressive oxidative scarring in polymerases. Unlike simple thermal denaturation, real‐time kinetic tracking dynamically visualizes enzymes degrading into multiple impaired subpopulations.
Anran Zheng, Qi Yang, Jinze Li, Fuqiang Ma, Xuefeng Wang, Zhen Guo, Chuanyu Li, Dongshu Li, Jia Yao, Zhiqi Zhang, Wei Zhang, Lianqun Zhou   +11 more
wiley   +1 more source

Concordance and Disconcordance of Serum Levels of Leptin with Leucocyte Telomere Length Across Spectrum of Adult Body Mass Index Among Indian Rural Population

Clinical and Research Journal in Internal Medicine, 2023
Background: Obesity is a prominent avoidable cause of mortality and a growing health concern in both adults and children throughout the world. The study's goal is to measure leucocyte telomere length and its relationship with leptin throughout the BMI ...
Anurag Yadav, L G Nandakumar, Anmol Manaswini Golla Yadav, Srivats Golla Yadav, Kaveri N Karewad   +4 more
doaj   +1 more source

Telomere length and cardiovascular aging

Annals of Medicine, 2012
Telomeres are located at the end of chromosomes. They are composed of repetitive TTAGGG tandem repeats and associated proteins of crucial importance for telomere function. Telomeric DNA is shortened by each cell division until a critical length is achieved and the cell enters senescence and eventually apoptosis.
Frej, Fyhrquist, Outi, Saijonmaa
openaire   +2 more sources

eEF1G Orchestrates Translation to Ensure Meiotic Progression in Transcriptionally Quiescent Spermatocytes

Advanced Science, EarlyView.
eEF1G supports translation elongation of meiotic mRNAs in transcriptionally quiescent leptotene and zygotene spermatocytes. Its depletion in germ cells causes meiotic arrest at the zygotene stage, with defective homologous synapsis and unstable recombination intermediates.
Jianze Xu, Yuwei Hu, Xukun Lu, Yuling Cai, Tongtong Li, Ming Gao, Jinlong Ma, Yuan Gao, Shangming Liu, Zi‐Jiang Chen, Jing Meng, Hongbin Liu, Xiaohua Jiang   +12 more
wiley   +1 more source

NONO, SFPQ, and PSPC1 promote telomerase recruitment to the telomere

Nature Communications
Telomerase is a ribonucleoprotein enzyme that maintains telomeric repeats on chromosome ends in continuously dividing cells. Telomere maintenance via telomerase is dependent on the correct assembly of the enzyme complex, complex stabilization by ...
Alexander P. Sobinoff, Jadon K. Wells, Maurice Chow, Christopher B. Nelson, Xinyi Wu, Scott B. Cohen, Yu Heng Lau, Tracy M. Bryan, Archa Fox, Hilda A. Pickett   +9 more
doaj   +1 more source

Association between lipoproteins and telomere length in US adults: data from the NHANES 1999–2002

Lipids in Health and Disease, 2019
Background Evidence regarding the correlation between lipoproteins and telomere length in US adults is limited. We aimed to investigate whether lipoproteins was associated with telomere length using US National Health and Nutrition Examination Survey ...
Yun-Fen Chen, Kai-Wen Zhou, Gui-zhen Yang, Chi Chen   +3 more
doaj   +1 more source

Whole‐Genome Sequencing Pilot of the Central Asian Genomic Diversity Project Reveals Distinct Histories, Adaptation, and Introgression

Advanced Science, EarlyView.
As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Lintao Luo, Jie Zhong, Zhaxylyk Sabitov, CAGDP Consortium†, Lan‐Hai Wei, Chao Liu, Maxat Zhabagin, Guanglin He   +11 more
wiley   +1 more source

Correlation of telomere length in brain tissue with peripheral tissues in living human subjects

Frontiers in Molecular Neuroscience
Telomeres are important to chromosomal stability, and changes in their length correlate with disease, potentially relevant to brain disorders. Assessing telomere length in human brain is invasive, but whether peripheral tissue telomere length correlates ...
Annemarie J. Carver, Annemarie J. Carver, Annemarie J. Carver, Benjamin Hing, Benjamin Hing, Benjamin A. Elser, Benjamin A. Elser, Benjamin A. Elser, Stephanie J. Lussier, Stephanie J. Lussier, Stephanie J. Lussier, Takehiko Yamanashi, Takehiko Yamanashi, Takehiko Yamanashi, Takehiko Yamanashi, Matthew A. Howard, Matthew A. Howard, Hiroto Kawasaki, Hiroto Kawasaki, Gen Shinozaki, Gen Shinozaki, Gen Shinozaki, Hanna E. Stevens, Hanna E. Stevens, Hanna E. Stevens, Hanna E. Stevens, Hanna E. Stevens   +26 more
doaj   +1 more source

Telomere length in myelodysplastic syndromes [PDF]

Leukemia & Lymphoma, 2011
The relationship between telomere length (TL) and predisposition to myelodysplastic syndromes (MDS) remains unclear. We compared peripheral blood leukocyte (PBL) TL among cases of histologically confirmed MDS (n = 65) who were treatment-naive with no prior cancer history to age-matched controls (n = 63).
Dana E, Rollison, P K, Epling-Burnette, Jong Y, Park, Ji-Hyun, Lee, Hyun, Park, Kristen, Jonathan, Ashley L, Cole, Jeffrey S, Painter, Mayenha, Guerrier, Johana, Meléndez-Santiago, William, Fulp, Rami, Komrokji, Jeffrey, Lancet, Alan F, List   +13 more
openaire   +2 more sources