Results 51 to 60 of about 62,113 (243)

Correlation of telomere length in brain tissue with peripheral tissues in living human subjects

Frontiers in Molecular Neuroscience
Telomeres are important to chromosomal stability, and changes in their length correlate with disease, potentially relevant to brain disorders. Assessing telomere length in human brain is invasive, but whether peripheral tissue telomere length correlates ...
Annemarie J. Carver, Annemarie J. Carver, Annemarie J. Carver, Benjamin Hing, Benjamin Hing, Benjamin A. Elser, Benjamin A. Elser, Benjamin A. Elser, Stephanie J. Lussier, Stephanie J. Lussier, Stephanie J. Lussier, Takehiko Yamanashi, Takehiko Yamanashi, Takehiko Yamanashi, Takehiko Yamanashi, Matthew A. Howard, Matthew A. Howard, Hiroto Kawasaki, Hiroto Kawasaki, Gen Shinozaki, Gen Shinozaki, Gen Shinozaki, Hanna E. Stevens, Hanna E. Stevens, Hanna E. Stevens, Hanna E. Stevens, Hanna E. Stevens   +26 more
doaj   +1 more source

Telomere length in myelodysplastic syndromes [PDF]

Leukemia & Lymphoma, 2011
The relationship between telomere length (TL) and predisposition to myelodysplastic syndromes (MDS) remains unclear. We compared peripheral blood leukocyte (PBL) TL among cases of histologically confirmed MDS (n = 65) who were treatment-naive with no prior cancer history to age-matched controls (n = 63).
Dana E, Rollison, P K, Epling-Burnette, Jong Y, Park, Ji-Hyun, Lee, Hyun, Park, Kristen, Jonathan, Ashley L, Cole, Jeffrey S, Painter, Mayenha, Guerrier, Johana, Meléndez-Santiago, William, Fulp, Rami, Komrokji, Jeffrey, Lancet, Alan F, List   +13 more
openaire   +2 more sources

Asymmetric Evolution of Antennal Cell Types Underlies a Derived Ammonia‐Sensing Logic for Ecological Adaptation in Bactrocera dorsalis

Advanced Science, EarlyView.
Comparative antennal single‐nucleus transcriptomics reveals cell‐type‐dependent transcriptomic divergence in Bactrocera dorsalis, with similar structural cells but divergent sensory neurons. This neuronal diversification is associated with a distinct ammonia‐sensing pathway, linking female attraction to bird‐dropping‐associated cues with nutritional ...
Wei Liu, Shuai Zhang, Jie Zhang, Zhen Tian, Yuanbo Xue, Ling Yang, Jun Xu, Guirong Wang   +7 more
wiley   +1 more source

DNA methylation and telomere length in 2–5 year olds with intrauterine preeclampsia exposure: a P4 sub-study

Clinical Epigenetics
Preeclampsia is a hypertensive disorder of pregnancy characterised by new onset hypertension at ≥ 20 weeks’ gestation accompanied by maternal organ dysfunction and/ or fetal compromise.
Jason P. Ross, Benjamin J. Varley, Jadon K. Wells, Robyn P. L. Yeh, Hilda A. Pickett, Raja S. Vasireddy, Lynne Roberts, Greg Davis, Amanda Henry, Maria E. Craig, Megan L. Gow   +10 more
doaj   +1 more source

Association between lipoproteins and telomere length in US adults: data from the NHANES 1999–2002

Lipids in Health and Disease, 2019
Background Evidence regarding the correlation between lipoproteins and telomere length in US adults is limited. We aimed to investigate whether lipoproteins was associated with telomere length using US National Health and Nutrition Examination Survey ...
Yun-Fen Chen, Kai-Wen Zhou, Gui-zhen Yang, Chi Chen   +3 more
doaj   +1 more source

Stimulation of OGG1 Enhances Oxidative DNA Damage Repair and Protects Against Acute Liver Failure by Acetaminophen

Advanced Science, EarlyView.
Chemical switching of OGG1 by CMM‐98 accelerates oxidative DNA damage repair and enhances hepatocyte resilience during acetaminophen‐induced acute liver injury. By promoting efficient processing of OGG1‐generated repair intermediates, CMM‐98 reduces oxidative damage, preserves cellular integrity, and protects against acute liver failure, identifying ...
Zhenjun Zhao, Rahul Upadhyay, Alice Eddershaw, Chenchen Wang, Yudong Zhao, Olov Wallner, Jinhye Ryu, Nayere Taebnia, Heather Gildie, Emma Scaletti‐Hutchinson, Jonathan R. Davies, Nicole Ziegler, Andreas Krämer, Samantha C. Robinson, Marek Varga, Karolina Singerova, Zuzanna Szaruga, Elisée Wiita, İrşil Güneş, Sheila S. David, Stefan Knapp, Aimo Kannt, Miguel de Vega, Pål Stenmark, Volker M Lauschke, Maurice Michel   +25 more
wiley   +1 more source

Association between telomere shortening and ageing during occupational exposure [PDF]

Journal of Medical Biochemistry, 2012
Telomere length is considered as a biomarker of ageing, resulting in shortening during the process. The present investigation was an attempt to determine the relative telomere length in mechanical workshop workers.
Sima Ataollahi Eshkoor, Fatemeh Jahanshiri, Patimah Ismail, Sabariah Abd Rahman, Moin Saidi, Mohd Yusoff Adon   +5 more
doaj  

Telomere Length: Implications for Atherogenesis

Current Atherosclerosis Reports, 2023
Abstract Purpose of Review The purpose of the study is to explore the evidence linking telomere length with atherosclerotic ischemic disease. Recent Findings There has been a recent expansion in strategies for measuring telomere length, including analyzing genome sequence ...
Hao Yin, J. Geoffrey Pickering
openaire   +2 more sources

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Telomere length in offspring is determined by mitochondrial-nuclear communication at fertilization

Nature Communications
The initial setting of telomere length during early life in each individual has a major influence on lifetime risk of aging-associated diseases; however there is limited knowledge of biological signals that regulate inheritance of telomere length, and ...
Yasmyn E. Winstanley, Ryan D. Rose, Alexander P. Sobinoff, Linda L. Wu, Deepak Adhikari, Qing-Hua Zhang, Jadon K. Wells, Lee H. Wong, Hazel H. Szeto, Sandra G. Piltz, Paul Q. Thomas, Mark A. Febbraio, John Carroll, Hilda A. Pickett, Darryl L. Russell, Rebecca L. Robker   +15 more
doaj   +1 more source