Results 21 to 30 of about 2,052,365 (293)

Telomere Length and Physical Performance at Older Ages: An Individual Participant Meta-Analysis [PDF]

, 2013
Background Telomeres are involved in cellular ageing and shorten with increasing age. If telomere length is a valuable biomarker of ageing, then telomere shortening should be associated with worse physical performance, an ageing trait, but evidence ...
Hardy, R, John M. Starr (107707), Cooper, R, Rachel Cooper, von Zglinicki, Thomas, Halcyon study team, Parsons, Sam, Martin-Ruiz, C., Lennox, Alison, Kuh, D., Murray, Emily, Yoav Ben-Shlomo, Aihie Sayer, Avan, Shiels, Paul G, Thomas von Zglinicki, Martin, Richard, Carmen Martin-Ruiz (126509), Cooper Cyrus, Hardy, R., Hardy, Rachel, Deary, Ian, Gardner, M.P., Team, HS, Cooper, Cryus, von Zglinicki, T., Sayer Avan Aihie, John M Starr, Shiels, P.G., Ben-Shlomo, Yoav, Ian J. Deary (107724), Harris, Sarah E, Gardner, Michael, Sayer, AA, Day, Ian, team, Halcyon study, Sarah E Harris, Ian J Deary, Gallacher, J., Aucott, Paula, Harris, Sarah, Martin-Ruiz, C, Paul G Shiels, Gardner, MP, Southall, Humphrey, Kuh, Diana, Rebecca Hardy (188906), von Zglinicki Thomas, Deary, Ian J, Michael P. Gardner (381155), Goodwin, James, Michael P Gardner, Thomas von Zglinicki (73277), Yoav Ben-Shlomo (95286), Alfred, Tamuno, Cooper, C., Diana Kuh, Gallacher John, Ben-Shlomo, Y., Starr John M., Deary Ian J., Elliott, Jane, Cooper, C, Starr, J.M., Shiels, Paul G., Shiels, Paul, Rachel Cooper (188902), Shiels, PG, Harris Sarah E., Kuh Diana, Gallacher, John, Gardner, Michael P., Craig, Leone, Richards, Marcus, Starr, John M., John Gallacher, Mulla, Zeinab, Starr, John M, Gale, Catherine, Ben-Shlomo, Y, Carmen Martin-Ruiz, Demakakos, Panos, Gardner, Mike P, Cyrus Cooper (141250), Cooper, R., John Gallacher (196569), Sayer, A.A., Cyrus Cooper, Harris, S.E., Hardy, Rebecca, McNeill, Geraldine, Starr, JM, Harris, SE, ?, ?, Avan Aihie Sayer, Cooper, Rachel, Deary, IJ, Cooper Rachel, Gardner, Michael P, Avan Aihie Sayer (188916), Rebecca Hardy, Whalley, Lawrence, Shiels Paul G., Martin-Ruiz Carmen, Hardy Rebecca, Martin-Ruiz, Carmen, Deary, Ian J., Tilling, Kate, Harris, Sarah E., Gardner Michael P., Cooper, Cyrus, Power, Chris, Paul G. Shiels (125083), Sayer, Avan Aihie, Gallacher, J, Mishra, Gita, von Zglinicki, T, Kuh, D, von, Zglinicki T, Steptoe, Andrew, Ben-Shlomo Yoav, Sarah E. Harris (107676), Diana Kuh (188923), Starr, John, Deary, I.J.   +123 more
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Genetic regulation of newborn telomere length is mediated and modified by DNA methylation

Frontiers in Genetics, 2022
Telomere length at birth determines later life telomere length and potentially predicts ageing-related diseases. However, the genetic and epigenetic settings of telomere length in newborns have not been analyzed.
Congrong Wang, Rossella Alfano, Brigitte Reimann, Janneke Hogervorst, Mariona Bustamante, Mariona Bustamante, Mariona Bustamante, Mariona Bustamante, Immaculata De Vivo, Immaculata De Vivo, Michelle Plusquin, Tim S. Nawrot, Tim S. Nawrot, Dries S. Martens   +13 more
doaj   +1 more source

Effect of telomere length on telomeric gene expression [PDF]

Nucleic Acids Research, 1996
Telomeres gradually shorten as human somatic cells divide and a correlation has been observed between the average telomere length and cell senescence. It has been proposed that the genes responsible for cell senescence are located near the telomere and are activated when telomere length reaches a critical point.
C N, Sprung, L, Sabatier, J P, Murnane
openaire   +2 more sources

Circulating leukocyte telomere length is highly heritable among families of Arab descent [PDF]

, 2012
Background Telomere length, an indicator of ageing and longevity, has been correlated with several biomarkers of cardiometabolic disease in both Arab children and adults.
Alokail Majed S, Shaun B Sabico, Assim A Alfadda, Sabico, Shaun, George P Chrousos, Omar S Al-Attas, Alokail, Majed S., Al-Attas, Omar S., Philip McTernan, Al-Daghri, Nasser M., Greg C Gibson, Al-Attas Omar S, Majed S Alokail, Gibson, Greg, Alkharfy Khalid M, Alfadda, Assim, Chrousos, George P., Gibson Greg C, Chrousos George P, McTernan Philip, Nasser M Al-Daghri, Sabico Shaun B, Al-Daghri Nasser M, Alfadda Assim A, Alkharfy, Khalid M., McTernan, P. G. (Philip G.), Khalid M Alkharfy   +26 more
core   +2 more sources

Author Correction: The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

Nature Communications, 2019
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Robert Lu, Julienne J. O’Rourke, Alexander P. Sobinoff, Joshua A. M. Allen, Christopher B. Nelson, Christopher G. Tomlinson, Michael Lee, Roger R. Reddel, Andrew J. Deans, Hilda A. Pickett   +9 more
doaj   +1 more source

Telomere length trajectory and its determinants in persons with coronary artery disease: longitudinal findings from the heart and soul study. [PDF]

PLoS ONE, 2010
Leukocyte telomere length, an emerging marker of biological age, has been shown to predict cardiovascular morbidity and mortality. However, the natural history of telomere length in patients with coronary artery disease has not been studied. We sought to
Ramin Farzaneh-Far, Jue Lin, Elissa Epel, Kyle Lapham, Elizabeth Blackburn, Mary A Whooley   +5 more
doaj   +1 more source

Measuring telomere length and telomere dynamics in evolutionary biology and ecology [PDF]

, 2014
Telomeres play a fundamental role in the protection of chromosomal DNA and in the regulation of cellular senescence. Recent work in human epidemiology and evolutionary ecology suggests adult telomere length (TL) may reflect past physiological stress and ...
Barrett, Emma, Boner, Winnie, Hartmann, Nils, Nussey, Daniel H., Turbill, Christopher (R16915), Verhulst, Simon; id_orcid, Baird, Duncan Martin, Turbill, Chris, Leder, Erica, Monaghan, Pat, Olsson, Mats, Zahn, Sandrine, Horn, Thorsten, Verhulst, Simon, Haussmann, Mark, Gemmell, Neil, Fairlie, Jennifer, Baird, Duncan   +17 more
core   +2 more sources

Telomere lengths in human oocytes, cleavage stage embryos and blastocysts [PDF]

, 2010
Telomeres are repeated sequences that protect the ends of chromosomes and harbour DNA-repair proteins. Telomeres shorten during each cell division in the absence of telomerase.
J. Rai, Rai, J., S. Turner, Wong, H. P., Hartshorne, Geraldine M., Turner, S., H. P. Wong, G. M. Hartshorne   +7 more
core   +1 more source

The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

Nature Communications, 2019
ALT telomeres experience DNA damage that may drive recombination-based telomere elongation. Here, the authors reveal that FANCM plays a critical role in the suppression of ALT activity through its interaction with the BTR (BLM-TOP3A-RMI) complex.
Robert Lu, Julienne J. O’Rourke, Alexander P. Sobinoff, Joshua A. M. Allen, Christopher B. Nelson, Christopher G. Tomlinson, Michael Lee, Roger R. Reddel, Andrew J. Deans, Hilda A. Pickett   +9 more
doaj   +1 more source

Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China. [PDF]

, 2013
A recent genome-wide association study of lung cancer among never-smoking females in Asia demonstrated that the rs2736100 polymorphism in the TERT-CLPTM1L locus on chromosome 5p15.33 was strongly and significantly associated with risk of adenocarcinoma ...
Xiang, Y, Hu W, Ji, BT, Wei Hu, Cai, Q, Chanock, S, Berndt S, Lan Qing, Hosgood, HD, H Dean Hosgood, Hu Wei, Kim Christopher, Cai Qiuyin, Shu X, Richard Cawthon, Barone-Adesi Francesco, Rothman Nathaniel, Cawthon R, Gao, Y, Sonja Berndt, Zheng Wei, Wong-Ho Chow, Chow WH, Stephen Chanock, BARONE ADESI, Francesco, Zheng W, Francesco Barone-Adesi, Bassig B, Yutang Gao, Berndt Sonja, Kim, C, Lan Q, Gao Y, Bryan Bassig, Hu, W, Rothman N., Berndt, S, Cawthon, R, Xiang Yongbin, Kim C, Christopher Kim, Cai Q, Yongbin Xiang, Xiaoou Shu, Bassig, B, Chanock Stephen, Chanock S, Shu Xiaoou, Chow Wong-Ho, Ji Bu-Tian, Barone-Adesi, F, Gao Yutang, Bassig Bryan, Shu, X, Qing Lan, Qiuyin Cai, Zheng, W, Rothman, N, Nathaniel Rothman, Hosgood H. Dean, Wei Zheng, Bu-Tian Ji, Chow, WH, Ji BT, Hosgood HD 3rd, Cawthon Richard, Xiang Y, Lan, Q   +67 more
core   +2 more sources