Results 11 to 20 of about 59,573 (233)

A mechanism for telomere-specific telomere length regulation. [PDF]

Nucleic Acids Res
Abstract Telomere length is a critical determinant of telomere function and hence chromosome stability. Critically short telomeres induce cellular senescence and division arrest, which eventually may lead to devastating age-related degenerative diseases. Conversely, maintenance of telomere length is a hallmark of cancer.
Teplitz GM, Pasquier E, Bonnell E, De Laurentiis E, Bartle L, Lucier JF, St-Laurent G, Dawson DS, Wellinger RJ.   +8 more
europepmc   +7 more sources

Telomere Length and Male Fertility [PDF]

International Journal of Molecular Sciences, 2021
Over the past decade, telomeres have attracted increasing attention due to the role they play in human fertility. However, conflicting results have been reported on the possible association between sperm telomere length (STL) and leukocyte telomere length (LTL) and the quality of the sperm parameters.
Gentiluomo M., Luddi A., Cingolani A., Fornili M., Governini L., Lucenteforte E., Baglietto L., Piomboni P., Campa D.   +8 more
openaire   +4 more sources

Telomeres and Telomere Length: A General Overview [PDF]

Cancers, 2020
Telomeres are highly conserved tandem nucleotide repeats that include proximal double-stranded and distal single-stranded regions that in complex with shelterin proteins afford protection at chromosomal ends to maintain genomic integrity. Due to the inherent limitations of DNA replication and telomerase suppression in most somatic cells, telomeres ...
Nalini Srinivas, Sivaramakrishna Rachakonda, Rajiv Kumar   +2 more
openaire   +2 more sources

Telomere Length [PDF]

Nursing Research, 2014
The exciting discovery that telomere shortening is associated with many health conditions and that telomere lengths can be altered in response to social and environmental exposures has underscored the need for methods to accurately and consistently quantify telomere length.The purpose of this article is to provide a comprehensive summary that compares ...
Alison J, Montpetit, Areej A, Alhareeri, Marty, Montpetit, Angela R, Starkweather, Lynne W, Elmore, Kristin, Filler, Lathika, Mohanraj, Candace W, Burton, Victoria S, Menzies, Debra E, Lyon, Colleen K, Jackson-Cook   +10 more
openaire   +5 more sources

Telomere length homeostasis [PDF]

Chromosoma, 2006
The physical ends of chromosomes, known as telomeres, protect chromosome ends from nucleolytic degradation and DNA repair activities. Conventional DNA replication enzymes lack the ability to fully replicate telomere ends. In addition, nucleolytic activities contribute to telomere erosion.
Hug N, Lingner J
openaire   +3 more sources

Telomere Length in the Newborn [PDF]

Pediatric Research, 2002
Telomere length is similar in different organs of the human fetus but variable among fetuses. During extrauterine life telomere length is highly variable among individuals and longer in women than men. In the present work we addressed the following questions: 1) Are there sex-related differences in telomere length at birth?
Koji, Okuda, Arlene, Bardeguez, Jeffrey P, Gardner, Paulette, Rodriguez, Vijaya, Ganesh, Masayuki, Kimura, Joan, Skurnick, Girgis, Awad, Abraham, Aviv   +8 more
openaire   +2 more sources

Telomere Length and Bipolar Disorder [PDF]

Neuropsychopharmacology, 2017
AbstractVariation in telomere length is heritable and is currently considered a promising biomarker of susceptibility for neuropsychiatric disorders, particularly because of its association with memory function and hippocampal morphology. Here, we investigate telomere length in connection to familial risk and disease expression in bipolar disorder (BD).
Timothy R Powell, Danai Dima, Sophia Frangou, Gerome Breen   +3 more
openaire   +7 more sources

Telomere length and reproductive aging [PDF]

Human Reproduction, 2009
Rate of reproductive aging may be related to rate of biological aging. Thus, indicators of aging, such as short telomere length, may be more frequent in women with a history suggestive of premature reproductive senescence.Telomere-specific quantitative PCR was used to assess telomere length in two groups of women with evidence of reproductive aging: (i)
Hanna, Courtney W., Bretherick, Karla L., Gair, Jane L., Fluker, Margo R., Stephenson, Mary D., Robinson, Wendy P.   +5 more
openaire   +2 more sources

Genetic regulation of newborn telomere length is mediated and modified by DNA methylation

Frontiers in Genetics, 2022
Telomere length at birth determines later life telomere length and potentially predicts ageing-related diseases. However, the genetic and epigenetic settings of telomere length in newborns have not been analyzed.
Congrong Wang, Rossella Alfano, Brigitte Reimann, Janneke Hogervorst, Mariona Bustamante, Mariona Bustamante, Mariona Bustamante, Mariona Bustamante, Immaculata De Vivo, Immaculata De Vivo, Michelle Plusquin, Tim S. Nawrot, Tim S. Nawrot, Dries S. Martens   +13 more
doaj   +1 more source

Effect of telomere length on telomeric gene expression [PDF]

Nucleic Acids Research, 1996
Telomeres gradually shorten as human somatic cells divide and a correlation has been observed between the average telomere length and cell senescence. It has been proposed that the genes responsible for cell senescence are located near the telomere and are activated when telomere length reaches a critical point.
C N, Sprung, L, Sabatier, J P, Murnane
openaire   +2 more sources