Results 11 to 20 of about 2,052,365 (293)

Analysis of telomere maintenance in artemis defective human cell lines [PDF]

, 2009
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Telomeres are physical ends of chromosomes consisting of (TTAGGG)n DNA sequence and a specialized set of proteins that protect chromosomal ends from ...
Yasaei, Hemad
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Telomere Length in the Newborn [PDF]

Pediatric Research, 2002
Telomere length is similar in different organs of the human fetus but variable among fetuses. During extrauterine life telomere length is highly variable among individuals and longer in women than men. In the present work we addressed the following questions: 1) Are there sex-related differences in telomere length at birth?
Koji, Okuda, Arlene, Bardeguez, Jeffrey P, Gardner, Paulette, Rodriguez, Vijaya, Ganesh, Masayuki, Kimura, Joan, Skurnick, Girgis, Awad, Abraham, Aviv   +8 more
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Telomere length homeostasis [PDF]

Chromosoma, 2006
The physical ends of chromosomes, known as telomeres, protect chromosome ends from nucleolytic degradation and DNA repair activities. Conventional DNA replication enzymes lack the ability to fully replicate telomere ends. In addition, nucleolytic activities contribute to telomere erosion.
Hug, N., Lingner, J.
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Progerin impairs 3D genome organization and induces fragile telomeres by limiting the dNTP pools

Scientific Reports, 2021
Chromatin organization within the nuclear volume is essential to regulate many aspects of its function and to safeguard its integrity. A key player in this spatial scattering of chromosomes is the nuclear envelope (NE).
Anna Kychygina, Marina Dall’Osto, Joshua A. M. Allen, Jean-Charles Cadoret, Vincent Piras, Hilda A. Pickett, Laure Crabbe   +6 more
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Telomere length and reproductive aging [PDF]

Human Reproduction, 2009
Rate of reproductive aging may be related to rate of biological aging. Thus, indicators of aging, such as short telomere length, may be more frequent in women with a history suggestive of premature reproductive senescence.Telomere-specific quantitative PCR was used to assess telomere length in two groups of women with evidence of reproductive aging: (i)
Hanna, Courtney W., Bretherick, Karla L., Gair, Jane L., Fluker, Margo R., Stephenson, Mary D., Robinson, Wendy P.   +5 more
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Telomere Length and Bipolar Disorder [PDF]

Neuropsychopharmacology, 2017
AbstractVariation in telomere length is heritable and is currently considered a promising biomarker of susceptibility for neuropsychiatric disorders, particularly because of its association with memory function and hippocampal morphology. Here, we investigate telomere length in connection to familial risk and disease expression in bipolar disorder (BD).
Timothy R Powell, Danai Dima, Sophia Frangou, Gerome Breen   +3 more
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Change in Leukocyte Telomere Length Predicts Mortality in Patients with Stable Coronary Heart Disease from the Heart and Soul Study. [PDF]

PLoS ONE, 2016
Short telomere length independently predicts mortality in patients with coronary heart disease. Whether 5-year change in telomere length predicts subsequent mortality in patients with coronary heart disease has not been evaluated.In a prospective cohort ...
Sarah E Goglin, Ramin Farzaneh-Far, Elissa S Epel, Jue Lin, Elizabeth H Blackburn, Mary A Whooley   +5 more
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Telomeres susceptibility to environmental arsenic exposure: Shortening or lengthening?

Frontiers in Public Health, 2023
Maintaining telomere length plays a crucial role in regulating cellular life span. Telomere lengthening or shortening is one of the important biomarkers which could predict the preceding or present diseases. Meanwhile, the impact of environmental arsenic
Kyi Mar Wai, Kyi Mar Wai, Thinzar Swe, Maw Thoe Myar, Cindy Rahman Aisyah, Thae Su Su Hninn   +5 more
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Is telomere length a biomarker for aging: cross-sectional evidence from the west of Scotland? [PDF]

, 2012
Background <p> The search for biomarkers of aging (BoAs) has been largely unsuccessful to-date and there is widespread skepticism about the prospects of finding any that satisfy the criteria developed by the American Federation of Aging Research ...
Batty, G.D., Robertson, T., Shiels, PG, Shiels Paul G., Benzeval, Michaela, Michaela Benzeval, McGlynn, Liane, G David Batty, Ian J Deary, McIntyre, A., McIntyre, A, Michael J Green, Benzeval, M, Tony Robertson, Der, G, Alan McIntyre, Paul G Shiels, McIntyre Alan, Robertson, Tony, Shiels, Paul G, Green, Michael J, Green, M.J., McGlynn Liane, McIntyre, Alan, Deary, Ian J, Der, Geoff, Robertson, T, Geoff Der, Green, MJ, McGlynn, L., McGlynn, L, Green Michael J., Deary, Ian, Deary Ian J., Der, G., Liane McGlynn, Batty G. David, McGlynn, Liane M, Robertson Tony, Batty, GD, Benzeval, M., Shiels, P.G., Batty, G David, Benzeval Michaela, Deary, IJ, Deary, I.J., Der Geoff   +46 more
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Childhood obesity is associated with shorter leukocyte telomere length [PDF]

, 2011
CONTEXT: Obesity in adults is associated with shorter mean leukocyte telomere length (LTL), a marker of biological age that is also associated with age-related conditions including cardiovascular disease and type 2 diabetes. However, studies of childhood
Meyre, D, Buxton, Jessica L., Meyre, David, Buxton, JL, Walters, RG, Sophie Visvikis-Siest, Visvikis-Siest, S, Walters, Robin G., Jessica L. Buxton, Blakemore, AI, Visvikis-Siest, Sophie, David Meyre, Robin G. Walters, Alexandra I. F. Blakemore, Philippe Froguel, Blakemore, Alexandra I. F., Froguel, P, Froguel, Philippe   +17 more
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