Telomeres and Telomere Length: A General Overview [PDF]
Cancers, 2020 Telomeres are highly conserved tandem nucleotide repeats that include proximal double-stranded and distal single-stranded regions that in complex with shelterin proteins afford protection at chromosomal ends to maintain genomic integrity.
Nalini Srinivas +2 more
semanticscholar +3 more sources
Telomere-driven diseases and telomere-targeting therapies [PDF]
Journal of Cell Biology, 2017 Martínez and Blasco review the molecular mechanisms underlying diseases associated with telomere dysfunction, including telomeropathies, age-related disorders, and cancer.
Paula Martínez, M. Blasco
semanticscholar +4 more sources
The relationship of telomere length to baseline corticosterone levels in nestlings of an altricial passerine bird in natural populations. [PDF]
, 2016 BackgroundEnvironmental stressors increase the secretion of glucocorticoids that in turn can shorten telomeres via oxidative damage. Modification of telomere length, as a result of adversity faced early in life, can modify an individual's phenotype ...
Guerrero, Claudia Jimena +4 more
core +6 more sources
The human telomeric proteome during telomere replication [PDF]
Nucleic Acids Research, 2020 Abstract Telomere shortening can cause detrimental diseases and contribute to aging. It occurs due to the end replication problem in cells lacking telomerase. Furthermore, recent studies revealed that telomere shortening can be attributed to difficulties of the semi-conservative DNA replication machinery to replicate the bulk of ...
Chih-Yi Gabriela Lin +5 more
openaire +3 more sources
EMBO reports, 2002 Telomeres are protein–DNA complexes that cap chromosome ends and protect them from being recognized and processed as DNA breaks. Loss of capping function results in genetic instability and loss of cellular viability. The emerging view is that maintenance of an appropriate telomere structure is essential for function. Structural information on telomeric
Daniela, Rhodes +4 more
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A ‘higher order’ of telomere regulation: telomere heterochromatin and telomeric RNAs [PDF]
The EMBO Journal, 2009 Protection of chromosome ends from DNA repair and degradation activities is mediated by specialized protein complexes bound to telomere repeats. Recently, it has become apparent that epigenetic regulation of the telomeric chromatin template critically impacts on telomere function and telomere-length homeostasis from yeast to man.
SCHOEFTNER, Stefan, Blasco Maria, A.
openaire +4 more sources
Oxidative stress, telomeres and cellular senescence: What non-drug interventions might break the link? [PDF]
, 2020 Telomeres are higher order structures that cap and protect chromosome ends. Telomeric DNA naturally shortens during somatic cell division and as a result of oxidative stress.
Erusalimsky, Jorge
core +1 more source
Alcohol consumption and leukocyte telomere length. [PDF]
, 2019 The relationship between alcohol consumption and mortality generally exhibits a U-shaped curve. The longevity observed with moderate alcohol consumption may be explained by other confounding factors, and, if such a relationship is present, the mechanism ...
Dixit, Shalini +9 more
core +2 more sources
Circulating leukocyte telomere length is highly heritable among families of Arab descent [PDF]
, 2012 Background Telomere length, an indicator of ageing and longevity, has been correlated with several biomarkers of cardiometabolic disease in both Arab children and adults.
AS Al-Rethaiaa +30 more
core +3 more sources
Telomere dysfunction accurately predicts clinical outcome in chronic lymphocytic leukaemia, even in patients with early stage disease [PDF]
, 2014 © 2014 John Wiley & Sons Ltd. Defining the prognosis of individual cancer sufferers remains a significant clinical challenge. Here we assessed the ability of high-resolution single telomere length analysis (STELA), combined with an experimentally ...
Allan, James M. +14 more
core +1 more source