Results 11 to 20 of about 116,824 (219)

Retrotransposons and Telomeres

Biochemistry (Moscow), 2023
Abstract Transposable elements (TEs) comprise a significant part of eukaryotic genomes being a major source of genome instability and mutagenesis. Cellular defense systems suppress the TE expansion at all stages of their life cycle.
Alla I, Kalmykova, Olesya A, Sokolova
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A ‘higher order’ of telomere regulation: telomere heterochromatin and telomeric RNAs [PDF]

The EMBO Journal, 2009
Protection of chromosome ends from DNA repair and degradation activities is mediated by specialized protein complexes bound to telomere repeats. Recently, it has become apparent that epigenetic regulation of the telomeric chromatin template critically impacts on telomere function and telomere-length homeostasis from yeast to man.
SCHOEFTNER, Stefan, Blasco Maria, A.
openaire   +4 more sources

Telomeres and Telomere Length: A General Overview [PDF]

Cancers, 2020
Telomeres are highly conserved tandem nucleotide repeats that include proximal double-stranded and distal single-stranded regions that in complex with shelterin proteins afford protection at chromosomal ends to maintain genomic integrity. Due to the inherent limitations of DNA replication and telomerase suppression in most somatic cells, telomeres ...
Nalini Srinivas, Sivaramakrishna Rachakonda, Rajiv Kumar   +2 more
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The Tail of the Telomere [PDF]

Journal of the American Chemical Society, 2008
The structure of a higher-order G-quadruplex structure for human telomeric DNA is presented. The structure was determined by a novel integrated approach in which molecular dynamics simulations were used to produce a stable structure, from which specific experimentally accessible properties were predicted.
PETRACCONE, LUIGI, John O. Trent, Jonathan B. Chaires   +2 more
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Telomeric RNAs are essential to maintain telomeres [PDF]

Nature Communications, 2016
AbstractTelomeres are transcribed generating long non-coding RNAs known as TERRA. Deciphering the role of TERRA has been one of the unsolved issues of telomere biology in the past decade. This has been, in part, due to lack of knowledge on the TERRA loci, thus preventing functional genetic studies. Here, we describe that long non-coding RNAs with TERRA
Juan José Montero, Isabel López de Silanes, Osvaldo Graña, Maria A. Blasco   +3 more
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Is telomere length a biomarker for aging: cross-sectional evidence from the west of Scotland? [PDF]

, 2012
Background <p> The search for biomarkers of aging (BoAs) has been largely unsuccessful to-date and there is widespread skepticism about the prospects of finding any that satisfy the criteria developed by the American Federation of Aging Research ...
Batty, G.D., Robertson, T., Shiels, PG, Shiels Paul G., Benzeval, Michaela, Michaela Benzeval, McGlynn, Liane, G David Batty, Ian J Deary, McIntyre, A., McIntyre, A, Michael J Green, Benzeval, M, Tony Robertson, Der, G, Alan McIntyre, Paul G Shiels, McIntyre Alan, Robertson, Tony, Shiels, Paul G, Green, Michael J, Green, M.J., McGlynn Liane, McIntyre, Alan, Deary, Ian J, Der, Geoff, Robertson, T, Geoff Der, Green, MJ, McGlynn, L., McGlynn, L, Green Michael J., Deary, Ian, Deary Ian J., Der, G., Liane McGlynn, Batty G. David, McGlynn, Liane M, Robertson Tony, Batty, GD, Benzeval, M., Shiels, P.G., Batty, G David, Benzeval Michaela, Deary, IJ, Deary, I.J., Der Geoff   +46 more
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Telomere lengths in human oocytes, cleavage stage embryos and blastocysts [PDF]

, 2010
Telomeres are repeated sequences that protect the ends of chromosomes and harbour DNA-repair proteins. Telomeres shorten during each cell division in the absence of telomerase.
J. Rai, Rai, J., S. Turner, Wong, H. P., Hartshorne, Geraldine M., Turner, S., H. P. Wong, G. M. Hartshorne   +7 more
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Trf1 is not required for proliferation or functional telomere maintenance in chicken DT40 cells [PDF]

, 2009
© 2009 by The American Society for Cell Biology.The telomere end-protection complex prevents the ends of linear eukaryotic chromosomes from degradation or inappropriate DNA repair. The homodimeric double-stranded DNA-binding protein, Trf1, is a component
Modino, S, Cooley, C, Cooley, C., Farr, CJ, Farr, C. J., Slijepcevic, P., Baird, K. M., Stewart, J. L., Slijepcevic, P, Baird, KM, Wenner, T., Stewart, JL, Faure, V., Morrison, C. G., Morrison, CG, Wenner, T, Modino, S., Faure, V   +17 more
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Childhood obesity is associated with shorter leukocyte telomere length [PDF]

, 2011
CONTEXT: Obesity in adults is associated with shorter mean leukocyte telomere length (LTL), a marker of biological age that is also associated with age-related conditions including cardiovascular disease and type 2 diabetes. However, studies of childhood
Meyre, D, Buxton, Jessica L., Meyre, David, Buxton, JL, Walters, RG, Sophie Visvikis-Siest, Visvikis-Siest, S, Walters, Robin G., Jessica L. Buxton, Blakemore, AI, Visvikis-Siest, Sophie, David Meyre, Robin G. Walters, Alexandra I. F. Blakemore, Philippe Froguel, Blakemore, Alexandra I. F., Froguel, P, Froguel, Philippe   +17 more
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Telomere reprogramming and maintenance in porcine iPS cells. [PDF]

PLoS ONE, 2013
Telomere reprogramming and silencing of exogenous genes have been demonstrated in mouse and human induced pluripotent stem cells (iPS cells). Pigs have the potential to provide xenotransplant for humans, and to model and test human diseases.
Guangzhen Ji, Weimin Ruan, Kai Liu, Fang Wang, Despoina Sakellariou, Jijun Chen, Yang Yang, Maja Okuka, Jianyong Han, Zhonghua Liu, Liangxue Lai, Sarantis Gagos, Lei Xiao, Hongkui Deng, Ning Li, Lin Liu   +15 more
doaj   +1 more source