Results 11 to 20 of about 92,549 (269)
Retrotransposons and Telomeres
Biochemistry (Moscow), 2023 Abstract Transposable elements (TEs) comprise a significant part of eukaryotic genomes being a major source of genome instability and mutagenesis. Cellular defense systems suppress the TE expansion at all stages of their life cycle.
Alla I, Kalmykova, Olesya A, Sokolova
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Telomeres and Telomere Length: A General Overview [PDF]
Cancers, 2020 Telomeres are highly conserved tandem nucleotide repeats that include proximal double-stranded and distal single-stranded regions that in complex with shelterin proteins afford protection at chromosomal ends to maintain genomic integrity. Due to the inherent limitations of DNA replication and telomerase suppression in most somatic cells, telomeres ...
Nalini Srinivas +2 more
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A ‘higher order’ of telomere regulation: telomere heterochromatin and telomeric RNAs [PDF]
The EMBO Journal, 2009 Protection of chromosome ends from DNA repair and degradation activities is mediated by specialized protein complexes bound to telomere repeats. Recently, it has become apparent that epigenetic regulation of the telomeric chromatin template critically impacts on telomere function and telomere-length homeostasis from yeast to man.
SCHOEFTNER, Stefan, Blasco Maria, A.
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The Tail of the Telomere [PDF]
Journal of the American Chemical Society, 2008 The structure of a higher-order G-quadruplex structure for human telomeric DNA is presented. The structure was determined by a novel integrated approach in which molecular dynamics simulations were used to produce a stable structure, from which specific experimentally accessible properties were predicted.
PETRACCONE, LUIGI +2 more
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Telomeric RNAs are essential to maintain telomeres [PDF]
Nature Communications, 2016 AbstractTelomeres are transcribed generating long non-coding RNAs known as TERRA. Deciphering the role of TERRA has been one of the unsolved issues of telomere biology in the past decade. This has been, in part, due to lack of knowledge on the TERRA loci, thus preventing functional genetic studies. Here, we describe that long non-coding RNAs with TERRA
Juan José Montero +3 more
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The human telomeric proteome during telomere replication [PDF]
Nucleic Acids Research, 2020 Abstract Telomere shortening can cause detrimental diseases and contribute to aging. It occurs due to the end replication problem in cells lacking telomerase. Furthermore, recent studies revealed that telomere shortening can be attributed to difficulties of the semi-conservative DNA replication machinery to replicate the bulk of ...
Chih-Yi Gabriela Lin +5 more
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Telomere reprogramming and maintenance in porcine iPS cells. [PDF]
PLoS ONE, 2013 Telomere reprogramming and silencing of exogenous genes have been demonstrated in mouse and human induced pluripotent stem cells (iPS cells). Pigs have the potential to provide xenotransplant for humans, and to model and test human diseases.
Guangzhen Ji +15 more
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Cytogenetic and Genome Research, 2013 In fishes, as in other vertebrate species, the DNA component of the telomeres consists of the tandemly repeated TTAGGG motif. The length of the telomeric arrays in fishes ranges from 2 to 25 kb and shortens with age in some of the species. To date, chromosomal distribution of the telomeric DNA sequences has been examined in approximately 80 fish ...
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Sir4 Deficiency Reverses Cell Senescence by Sub-Telomere Recombination
Cells, 2021 Telomere shortening results in cellular senescence and the regulatory mechanisms remain unclear. Here, we report that the sub-telomere regions facilitate telomere lengthening by homologous recombination, thereby attenuating senescence in yeast ...
Jun Liu +4 more
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Exercise, Telomeres, and Cancer: “The Exercise-Telomere Hypothesis” [PDF]
Frontiers in Physiology, 2018 Telomeres are genomic complex at the end of chromosomes that protects the DNA and telomere length (TL) is related to several age-related diseases, lifespan, and cancer. On the other hand, cancer is a multifactorial disease that is responsible for reduce the quality of life and kills millions of people every year. Both, shorter TL and cancer are related
Nikitas N. Nomikos +6 more
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