Results 41 to 50 of about 128,303 (302)

Telomere tracking from birth to adulthood and residential traffic exposure

BMC Medicine, 2017
Background Telomere attrition is extremely rapid during the first years of life, while lifestyle during adulthood exerts a minor impact. This suggests that early life is an important period in the determination of telomere length.
Esmée M. Bijnens, Maurice P. Zeegers, Catherine Derom, Dries S. Martens, Marij Gielen, Geja J. Hageman, Michelle Plusquin, Evert Thiery, Robert Vlietinck, Tim S. Nawrot   +9 more
doaj   +1 more source

Why and when should organisms elongate their telomeres? Elaborations on the ‘excess resources elongation’ and ‘last resort elongation’ hypotheses

Ecology and Evolution, 2023
Telomere length and telomere shortening are thought to be critical cellular attributes and processes that are related to an individual's life span and fitness.
David Gómez‐Blanco, Michael Tobler, Dennis Hasselquist   +2 more
doaj   +1 more source

Inhibition of lagging strand replication by G-rich telomeric DNA and the shelterin subunit POT1

The EMBO Journal
Telomeres preserve stable eukaryotic chromosomes by protecting the natural chromosome ends from DNA repair but pose a persistent challenge to the replication machinery and an endogenous source of replication stress.
Ciara Leonard-Booker, Giulia Mazzucco, Charlotte E L Fisher, Karim Hussain, Tom D Deegan, Ylli Doksani, Max E Douglas   +6 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Telomere Length and Distribution in Three Developmental Stages [PDF]

, 2014
Telomeres are specialised nucleoprotein structures present at the ends of each chromatid that function to maintain genome stability. It is well established that a gradual decline in telomere length is associated with the process of cellular ageing, and ...
Digital Scientific, Turner, Kara Jane
core  

The effect of chemotherapeutic agents on telomere length maintenance in breast cancer cell lines [PDF]

, 2014
Copyright @ 2014 the authors. This article is made available through the Brunel Open Access Publishing Fund. It is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution ...
Slijepcevic, P, Terry Roberts, Yasaei, H, Roberts, T, Azadeh Motevalli, Motevalli, A, Predrag Slijepcevic, Sara Anjomani Virmouni, Hemad Yasaei, Virmouni, SA   +9 more
core   +1 more source

Distinct modes of telomere synthesis and extension contribute to Alternative Lengthening of Telomeres

iScience
Summary: Alternative lengthening of telomeres (ALT) is a homology-directed repair mechanism that becomes activated in a subset of cancers to maintain telomere length.
Robert Lu, Christopher B. Nelson, Samuel Rogers, Anthony J. Cesare, Alexander P. Sobinoff, Hilda A. Pickett   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural basis for Rap1-Rif1-Rif2 assembly : insights into budding yeast telomere architecture and functions [PDF]

, 2012
Telomeres form the ends of eukaryotic linear chromosomes and are composed of specialized nucleoprotein complexes. They have been the subject of intense investigation over several decades, as telomere dysfunction has been associated with genome ...
Tianlai, Shi
core   +1 more source

Telomere-to-telomere assemblies and annotation data for Gossypium raimondii

, 2023
Telomere-to-telomere assemblies and annotation data for Gossypium ...
Gai Huang (12980537)
core   +1 more source