Rate of telomere shortening and cardiovascular damage: a longitudinal study in the 1946 British Birth Cohort. [PDF]
, 2014 Cross-sectional studies reported associations between short leucocyte telomere length (LTL) and measures of vascular and cardiac damage. However, the contribution of LTL dynamics to the age-related process of cardiovascular (CV) remodelling remains ...
Kahn, T +26 more
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Identification of Neuroblastoma Subgroups Based on Three-Dimensional Telomere Organization
Translational Oncology, 2016 Using 3D telomere quantitative fluorescence in situ hybridization, we determined the 3D telomere organization of 74 neuroblastoma tissue samples. Hierarchical cluster analysis of the measured telomere parameters identified three subgroups from our ...
Alexandra Kuzyk +2 more
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Accelerated telomere attrition is associated with relative household income, diet and inflammation in the pSoBid cohort [PDF]
, 2011 BACKGROUND: It has previously been hypothesized that lower socio-economic status can accelerate biological ageing, and predispose to early onset of disease.
Batty, G.D. +110 more
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Telomere tracking from birth to adulthood and residential traffic exposure
BMC Medicine, 2017 Background Telomere attrition is extremely rapid during the first years of life, while lifestyle during adulthood exerts a minor impact. This suggests that early life is an important period in the determination of telomere length.
Esmée M. Bijnens +9 more
doaj +1 more source
Ecology and Evolution, 2023 Telomere length and telomere shortening are thought to be critical cellular attributes and processes that are related to an individual's life span and fitness.
David Gómez‐Blanco +2 more
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The effect of chemotherapeutic agents on telomere length maintenance in breast cancer cell lines [PDF]
, 2014 Copyright @ 2014 the authors. This article is made available through the Brunel Open Access Publishing Fund. It is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution ...
Slijepcevic, P +9 more
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Inhibition of lagging strand replication by G-rich telomeric DNA and the shelterin subunit POT1
The EMBO JournalTelomeres preserve stable eukaryotic chromosomes by protecting the natural chromosome ends from DNA repair but pose a persistent challenge to the replication machinery and an endogenous source of replication stress.
Ciara Leonard-Booker +6 more
doaj +1 more source
iScienceSummary: Alternative lengthening of telomeres (ALT) is a homology-directed repair mechanism that becomes activated in a subset of cancers to maintain telomere length.
Robert Lu +5 more
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ATM Kinase Is Required for Telomere Elongation in Mouse and Human Cells
Cell Reports, 2015 Short telomeres induce a DNA damage response, senescence, and apoptosis, thus maintaining telomere length equilibrium is essential for cell viability. Telomerase addition of telomere repeats is tightly regulated in cells.
Stella Suyong Lee +4 more
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Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China. [PDF]
, 2013 A recent genome-wide association study of lung cancer among never-smoking females in Asia demonstrated that the rs2736100 polymorphism in the TERT-CLPTM1L locus on chromosome 5p15.33 was strongly and significantly associated with risk of adenocarcinoma ...
Xiang, Y +67 more
core +2 more sources