Results 41 to 50 of about 116,824 (219)

Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China. [PDF]

, 2013
A recent genome-wide association study of lung cancer among never-smoking females in Asia demonstrated that the rs2736100 polymorphism in the TERT-CLPTM1L locus on chromosome 5p15.33 was strongly and significantly associated with risk of adenocarcinoma ...
Xiang, Y, Hu W, Ji, BT, Wei Hu, Cai, Q, Chanock, S, Berndt S, Lan Qing, Hosgood, HD, H Dean Hosgood, Hu Wei, Kim Christopher, Cai Qiuyin, Shu X, Richard Cawthon, Barone-Adesi Francesco, Rothman Nathaniel, Cawthon R, Gao, Y, Sonja Berndt, Zheng Wei, Wong-Ho Chow, Chow WH, Stephen Chanock, BARONE ADESI, Francesco, Zheng W, Francesco Barone-Adesi, Bassig B, Yutang Gao, Berndt Sonja, Kim, C, Lan Q, Gao Y, Bryan Bassig, Hu, W, Rothman N., Berndt, S, Cawthon, R, Xiang Yongbin, Kim C, Christopher Kim, Cai Q, Yongbin Xiang, Xiaoou Shu, Bassig, B, Chanock Stephen, Chanock S, Shu Xiaoou, Chow Wong-Ho, Ji Bu-Tian, Barone-Adesi, F, Gao Yutang, Bassig Bryan, Shu, X, Qing Lan, Qiuyin Cai, Zheng, W, Rothman, N, Nathaniel Rothman, Hosgood H. Dean, Wei Zheng, Bu-Tian Ji, Chow, WH, Ji BT, Hosgood HD 3rd, Cawthon Richard, Xiang Y, Lan, Q   +67 more
core   +1 more source

Why and when should organisms elongate their telomeres? Elaborations on the ‘excess resources elongation’ and ‘last resort elongation’ hypotheses

Ecology and Evolution, 2023
Telomere length and telomere shortening are thought to be critical cellular attributes and processes that are related to an individual's life span and fitness.
David Gómez‐Blanco, Michael Tobler, Dennis Hasselquist   +2 more
doaj   +1 more source

Telomeric recombination induced by dysfunctional telomeres

Molecular Biology of the Cell, 2011
 Telomere maintenance is essential for cellular immortality, and most cancer cells maintain their telomeres through the enzyme telomerase. Telomeres and telomerase represent promising anticancer targets. However, 15% of cancer cells maintain their telomeres through alternative recombination-based mechanisms, and previous analyses showed that ...
Brault, Marie Eve, Autexier, Chantal
openaire   +2 more sources

Suv4-20h abrogation enhances telomere elongation during reprogramming and confers a higher tumorigenic potential to iPS cells [PDF]

, 2011
Reprogramming of adult differentiated cells to induced pluripotent stem cells (iPS) cells has been achieved by over-expression of specific transcription factors.
Maria A. Blasco, Maria A Blasco, Marión, Rosa M., Ortega Sagrario, Marión Rosa M., Schotta Gunnar, Blasco Maria A., Schotta, Gunnar, Rosa M. Marión, Blasco, Maria A., Gunnar Schotta, Sagrario Ortega, Rosa M Marión, Ortega, Sagrario   +13 more
core   +1 more source

Defective Artemis causes mild telomere dysfunction

, 2010
This article has been made available through the Brunel Open Access Publishing Fund.Background: Repair of DNA double strand breaks by non-homologous end joining (NHEJ) requires several proteins including Ku, DNA-PKcs, Artemis, XRCC4, Ligase IV and XLF ...
Slijepcevic, P, Yasaei, H, Predrag Slijepcevic, Hemad Yasaei   +3 more
core   +1 more source

Rate of telomere shortening and cardiovascular damage: a longitudinal study in the 1946 British Birth Cohort. [PDF]

, 2014
Cross-sectional studies reported associations between short leucocyte telomere length (LTL) and measures of vascular and cardiac damage. However, the contribution of LTL dynamics to the age-related process of cardiovascular (CV) remodelling remains ...
Kahn, T, Kahn, Tauseef, Hardy, R, Von Zglinicki, Thomas, D'Aiuto, F, MASI, STEFANO, Martin-Ruiz, C, Ghosh, AK, Hughes, A, Deanfield, John Eric, Wong, A, Kuh, Diana, Masi, S, NSHD scientific and data collection teams, ., Whincup, Peter, von Zglinicki, T, Hardy, Rebecca, Whincup, P, Deanfield, JE, Kuh, D, NSHD scientific and data collection teams, Wong, Andrew, D'Aiuto, Francesco, Ghosh, Arjun K., Hughes, Alan, Martin Ruiz, Carmen   +25 more
core   +1 more source

Telomere length attrition, a marker of biological senescence, is inversely correlated with triglycerides and cholesterol in South Asian males with type 2 diabetes mellitus [PDF]

, 2012
South Asians have a higher risk of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) than white Caucasians, for a given BMI. Premature biological ageing, assessed by reduction in telomere length (TL), may be mediated by factors resulting ...
Miller, M.A., da Silva, NF, Barnett, Anthony H., Al-Attas, O., Miller, MA, da Silva, Nancy F., Kelly, M. Ann, Tripathi, G, Al-Attas, Omar S., Al-Daghri, Nasser M., Cappuccio, Francesco, Kelly, Ann M., Bellary, Srikanth, Kumar, S., da Silva, N.F., McTernan, Philip G., Sabico, S, O'Hare, JP, Tripathi, Gyanendra, Cappuccio, Francesco P., McTernan, P. G., Alokail, M., Al-Daghri, NM, Al-Attas, Omar, Miller, Michelle A., Al-Daghri, N.M., Harte, A.L., Bellary, S., Barnett, Anthony, Bellary, S, Al-Daghri, Nasser M, Kelly, A., Sabico, Shaun, McTernan, PG, Alokail, Majed S., Al-Attas, O, Alokail, M, Tripathi, G., Barnett, A.H., Harte, AL, Harte, Alison L., Kelly, A, O'Hare, Joseph P., Kumar, Sudhesh, O'Hare, J.P., Sabico, S., Cappuccio, FP, Alokail, Majed, McTernan, P.G., Kumar, S, O'Hare, J. Paul, Cappuccio, F.P.   +51 more
core   +1 more source

Distinct modes of telomere synthesis and extension contribute to Alternative Lengthening of Telomeres

iScience
Summary: Alternative lengthening of telomeres (ALT) is a homology-directed repair mechanism that becomes activated in a subset of cancers to maintain telomere length.
Robert Lu, Christopher B. Nelson, Samuel Rogers, Anthony J. Cesare, Alexander P. Sobinoff, Hilda A. Pickett   +5 more
doaj   +1 more source

Telomere Length and Distribution in Three Developmental Stages [PDF]

, 2014
Telomeres are specialised nucleoprotein structures present at the ends of each chromatid that function to maintain genome stability. It is well established that a gradual decline in telomere length is associated with the process of cellular ageing, and ...
Digital Scientific, Turner, Kara Jane
core  

Senescence, Telomere Shortening and Telomere Maintenance [PDF]

Cancer Biology & Therapy, 2002
No Abstract Available Commentary to: Title: Telomerase Protects Cancer-Prone Human Cells from Chromosomal Instability and Spontaneous Immortalization Authors: Lynne W. Elmore, Kristi C. Turner, Lauren S. Gollahon, Melissa R. Landon, Colleen K. Jackson-Cook and Shawn E.
openaire   +2 more sources