Results 61 to 70 of about 130,635 (210)

hnRNPA2 mediated acetylation reduces telomere length in response to mitochondrial dysfunction.

PLoS ONE, 2018
Telomeres protect against chromosomal damage. Accelerated telomere loss has been associated with premature aging syndromes such as Werner's syndrome and Dyskeratosis Congenita, while, progressive telomere loss activates a DNA damage response leading to ...
Manti Guha, Satish Srinivasan, F Bradley Johnson, Gordon Ruthel, Kip Guja, Miguel Garcia-Diaz, Brett A Kaufman, M Rebecca Glineburg, JiKang Fang, Hiroshi Nakagawa, Jeelan Basha, Tapas Kundu, Narayan G Avadhani   +12 more
doaj   +1 more source

Telomere length and incident atrial fibrillation - data of the PREVEND cohort.

PLoS ONE, 2017
BackgroundThe incidence of atrial fibrillation (AF) increases with age. Telomere length is considered a marker of biological ageing. We investigated the association between leukocyte telomere length and incident AF in the Dutch Prevention of Renal and ...
Joylene E Siland, Bastiaan Geelhoed, Isabelle C van Gelder, Pim van der Harst, Michiel Rienstra   +4 more
doaj   +1 more source

Telomere architecture [PDF]

The EMBO Reports, 2002
Telomeres are protein-DNA complexes that cap chromosome ends and protect them from being recognized and processed as DNA breaks. Loss of capping function results in genetic instability and loss of cellular viability. The emerging view is that maintenance of an appropriate telomere structure is essential for function. Structural information on telomeric
Daniela, Rhodes, Louise, Fairall, Tomas, Simonsson, Robert, Court, Lynda, Chapman   +4 more
openaire   +2 more sources

NONO, SFPQ, and PSPC1 promote telomerase recruitment to the telomere

Nature Communications
Telomerase is a ribonucleoprotein enzyme that maintains telomeric repeats on chromosome ends in continuously dividing cells. Telomere maintenance via telomerase is dependent on the correct assembly of the enzyme complex, complex stabilization by ...
Alexander P. Sobinoff, Jadon K. Wells, Maurice Chow, Christopher B. Nelson, Xinyi Wu, Scott B. Cohen, Yu Heng Lau, Tracy M. Bryan, Archa Fox, Hilda A. Pickett   +9 more
doaj   +1 more source

Telomere Length Abnormality: Investigating Approaches and Correlations with Cancer, Bone Marrow Failure and Hematological Malignancies

Biomedicines
Proper telomere maintenance is crucial for ensuring healthy cellular function. Telomeres have a tendency to reduce in length with cellular aging. Moreover several factors may promote telomere attrition.
Corrado Tarella, Dario Ferrero, Maria Beatriz Herrera Sanchez, Alessia Rita Canestrale, Sharad Kholia, Lorenzo Silengo, Enrico Derenzini, Irene Ricca   +7 more
doaj   +1 more source

Telomere Length and Distribution in Three Developmental Stages [PDF]

, 2014
Telomeres are specialised nucleoprotein structures present at the ends of each chromatid that function to maintain genome stability. It is well established that a gradual decline in telomere length is associated with the process of cellular ageing, and ...
Digital Scientific, Turner, Kara Jane
core  

Characterization and consequences of Telomere replication gone awry [PDF]

, 2008
Telomeres, the ends of linear eukaryotic chromosomes, pose several unique challenges to genome stability. My thesis work is concerned with the difficulties the replication machinery encounters when attempting to replicate telomeres, and with possible ...
Rog, O., Rog, O
core  

Structural basis for Rap1-Rif1-Rif2 assembly : insights into budding yeast telomere architecture and functions [PDF]

, 2012
Telomeres form the ends of eukaryotic linear chromosomes and are composed of specialized nucleoprotein complexes. They have been the subject of intense investigation over several decades, as telomere dysfunction has been associated with genome ...
Tianlai, Shi
core   +1 more source

Depleting components of the THO complex causes increased telomere length by reducing the expression of the telomere-associated protein Rif1p. [PDF]

PLoS ONE, 2012
Telomere length is regulated mostly by proteins directly associated with telomeres. However, genome-wide analysis of Saccharomyces cerevisiae mutants has revealed that deletion of Hpr1p, a component of the THO complex, also affects telomere length.
Tai-Yuan Yu, Chen-Yi Wang, Jing-Jer Lin
doaj   +1 more source

Telomere length attrition, a marker of biological senescence, is inversely correlated with triglycerides and cholesterol in South Asian males with type 2 diabetes mellitus [PDF]

, 2012
South Asians have a higher risk of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) than white Caucasians, for a given BMI. Premature biological ageing, assessed by reduction in telomere length (TL), may be mediated by factors resulting ...
Miller, M.A., da Silva, NF, Barnett, Anthony H., Al-Attas, O., Miller, MA, da Silva, Nancy F., Kelly, M. Ann, Tripathi, G, Al-Attas, Omar S., Al-Daghri, Nasser M., Cappuccio, Francesco, Kelly, Ann M., Bellary, Srikanth, Kumar, S., da Silva, N.F., McTernan, Philip G., Sabico, S, O'Hare, JP, Tripathi, Gyanendra, Cappuccio, Francesco P., McTernan, P. G., Alokail, M., Al-Daghri, NM, Al-Attas, Omar, Miller, Michelle A., Al-Daghri, N.M., Harte, A.L., Bellary, S., Barnett, Anthony, Bellary, S, Al-Daghri, Nasser M, Kelly, A., Sabico, Shaun, McTernan, PG, Alokail, Majed S., Al-Attas, O, Alokail, M, Tripathi, G., Barnett, A.H., Harte, AL, Harte, Alison L., Kelly, A, O'Hare, Joseph P., Kumar, Sudhesh, O'Hare, J.P., Sabico, S., Cappuccio, FP, Alokail, Majed, McTernan, P.G., Kumar, S, O'Hare, J. Paul, Cappuccio, F.P.   +51 more
core   +1 more source