Results 61 to 70 of about 116,824 (219)
Cell cycle-dependent modification of Pot1 and its effects on telomere function [PDF]
, 2009 Telomere functions are tightly controlled throughout the cell cycle to allow telomerase access while suppressing a bona fide DNA damage response (DDR) at linear chromosome ends.
Kuznetsov, V, Kuznetsov, V.
core
Epigenetic telomere protection by Drosophila DNA damage response pathways. [PDF]
PLoS Genetics, 2006 Analysis of terminal deletion chromosomes indicates that a sequence-independent mechanism regulates protection of Drosophila telomeres. Mutations in Drosophila DNA damage response genes such as atm/tefu, mre11, or rad50 disrupt telomere protection and ...
Sarah R Oikemus +5 more
doaj +2 more sources
NONO, SFPQ, and PSPC1 promote telomerase recruitment to the telomere
Nature CommunicationsTelomerase is a ribonucleoprotein enzyme that maintains telomeric repeats on chromosome ends in continuously dividing cells. Telomere maintenance via telomerase is dependent on the correct assembly of the enzyme complex, complex stabilization by ...
Alexander P. Sobinoff +9 more
doaj +1 more source
BiomedicinesProper telomere maintenance is crucial for ensuring healthy cellular function. Telomeres have a tendency to reduce in length with cellular aging. Moreover several factors may promote telomere attrition.
Corrado Tarella +7 more
doaj +1 more source
Neoplasia: An International Journal for Oncology Research, 2014 Defects in telomere maintenance can result in telomere fusions that likely play a causative role in carcinogenesis by promoting genomic instability. However, this proposition remains to be fully understood in human colon carcinogenesis.
Hiromi Tanaka +2 more
doaj +1 more source
The EMBO Journal, 2009 The telomeres of most eukaryotes are characterized by guanine-rich repeats synthesized by the reverse transcriptase telomerase. Complete loss of telomerase is tolerated for several generations in most species, but modestly reduced telomerase levels in human beings are implicated in bone marrow failure, pulmonary fibrosis and a spectrum of other ...
openaire +2 more sources
Telomere-to-telomere analysis of CA14/NRRL 3357 AT indels in A. flavus chromosomes.
, 2023 Telomere-to-telomere analysis of CA14/NRRL 3357 AT indels in A. flavus chromosomes.
Arthur J. Lustig (14593621)
core +1 more source
Telomere length and incident atrial fibrillation - data of the PREVEND cohort.
PLoS ONE, 2017 BackgroundThe incidence of atrial fibrillation (AF) increases with age. Telomere length is considered a marker of biological ageing. We investigated the association between leukocyte telomere length and incident AF in the Dutch Prevention of Renal and ...
Joylene E Siland +4 more
doaj +1 more source
hnRNPA2 mediated acetylation reduces telomere length in response to mitochondrial dysfunction.
PLoS ONE, 2018 Telomeres protect against chromosomal damage. Accelerated telomere loss has been associated with premature aging syndromes such as Werner's syndrome and Dyskeratosis Congenita, while, progressive telomere loss activates a DNA damage response leading to ...
Manti Guha +12 more
doaj +1 more source
Exercise, Telomeres, and Cancer: “The Exercise-Telomere Hypothesis” [PDF]
Frontiers in Physiology, 2018 Telomeres are genomic complex at the end of chromosomes that protects the DNA and telomere length (TL) is related to several age-related diseases, lifespan, and cancer. On the other hand, cancer is a multifactorial disease that is responsible for reduce the quality of life and kills millions of people every year. Both, shorter TL and cancer are related
Nikitas N. Nomikos +6 more
openaire +5 more sources