Results 61 to 70 of about 128,303 (302)

Rate of telomere shortening and cardiovascular damage: a longitudinal study in the 1946 British Birth Cohort. [PDF]

, 2014
Cross-sectional studies reported associations between short leucocyte telomere length (LTL) and measures of vascular and cardiac damage. However, the contribution of LTL dynamics to the age-related process of cardiovascular (CV) remodelling remains ...
Kahn, T, Kahn, Tauseef, Hardy, R, Von Zglinicki, Thomas, D'Aiuto, F, MASI, STEFANO, Martin-Ruiz, C, Ghosh, AK, Hughes, A, Deanfield, John Eric, Wong, A, Kuh, Diana, Masi, S, NSHD scientific and data collection teams, ., Whincup, Peter, von Zglinicki, T, Hardy, Rebecca, Whincup, P, Deanfield, JE, Kuh, D, NSHD scientific and data collection teams, Wong, Andrew, D'Aiuto, Francesco, Ghosh, Arjun K., Hughes, Alan, Martin Ruiz, Carmen   +25 more
core   +1 more source

ZNF827 is a single-stranded DNA binding protein that regulates the ATR-CHK1 DNA damage response pathway

Nature Communications
The ATR-CHK1 DNA damage response pathway becomes activated by the exposure of RPA-coated single-stranded DNA (ssDNA) that forms as an intermediate during DNA damage and repair, and as a part of the replication stress response. Here, we identify ZNF827 as
Sile F. Yang, Christopher B. Nelson, Jadon K. Wells, Madushan Fernando, Robert Lu, Joshua A. M. Allen, Lisa Malloy, Noa Lamm, Vincent J. Murphy, Joel P. Mackay, Andrew J. Deans, Anthony J. Cesare, Alexander P. Sobinoff, Hilda A. Pickett   +13 more
doaj   +1 more source

Human SKI component SKIV2L regulates telomeric DNA-RNA hybrids and prevents telomere fragility

iScience
Summary: Super killer (SKI) complex is a well-known cytoplasmic 3′–5′ mRNA decay complex that functions with the exosome to degrade excessive and aberrant mRNAs, is implicated with the extraction of mRNA at stalled ribosomes, tackling aberrant ...
Emilia Herrera-Moyano, Rosa Maria Porreca, Lepakshi Ranjha, Eleni Skourti, Roser Gonzalez-Franco, Emmanouil Stylianakis, Ying Sun, Ruihan Li, Almutasem Saleh, Alex Montoya, Holger Kramer, Jean-Baptiste Vannier   +11 more
doaj   +1 more source

Telomeres in Space

Aging Cell
ABSTRACTRecent studies have reported that the spaceflight environment lengthens leukocyte telomeres. We propose that this baffling finding reflects changes in the composition of leukocyte subsets rather than an actual increase in telomere length within individual leukocytes.
Abraham Aviv, Simon Verhulst
openaire   +2 more sources

The telomere syndromes [PDF]

Nature Reviews Genetics, 2012
There has been mounting evidence of a causal role for telomere dysfunction in a number of degenerative disorders. Their manifestations encompass common disease states such as idiopathic pulmonary fibrosis and bone marrow failure. Although these disorders seem to be clinically diverse, collectively they comprise a single syndrome spectrum defined by the
Armanios, Mary, Blackburn, Elizabeth H
openaire   +4 more sources

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Cell cycle-dependent modification of Pot1 and its effects on telomere function [PDF]

, 2009
Telomere functions are tightly controlled throughout the cell cycle to allow telomerase access while suppressing a bona fide DNA damage response (DDR) at linear chromosome ends.
Kuznetsov, V, Kuznetsov, V.
core  

Telomere length attrition, a marker of biological senescence, is inversely correlated with triglycerides and cholesterol in South Asian males with type 2 diabetes mellitus [PDF]

, 2012
South Asians have a higher risk of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) than white Caucasians, for a given BMI. Premature biological ageing, assessed by reduction in telomere length (TL), may be mediated by factors resulting ...
Miller, M.A., da Silva, NF, Barnett, Anthony H., Al-Attas, O., Miller, MA, da Silva, Nancy F., Kelly, M. Ann, Tripathi, G, Al-Attas, Omar S., Al-Daghri, Nasser M., Cappuccio, Francesco, Kelly, Ann M., Bellary, Srikanth, Kumar, S., da Silva, N.F., McTernan, Philip G., Sabico, S, O'Hare, JP, Tripathi, Gyanendra, Cappuccio, Francesco P., McTernan, P. G., Alokail, M., Al-Daghri, NM, Al-Attas, Omar, Miller, Michelle A., Al-Daghri, N.M., Harte, A.L., Bellary, S., Barnett, Anthony, Bellary, S, Al-Daghri, Nasser M, Kelly, A., Sabico, Shaun, McTernan, PG, Alokail, Majed S., Al-Attas, O, Alokail, M, Tripathi, G., Barnett, A.H., Harte, AL, Harte, Alison L., Kelly, A, O'Hare, Joseph P., Kumar, Sudhesh, O'Hare, J.P., Sabico, S., Cappuccio, FP, Alokail, Majed, McTernan, P.G., Kumar, S, O'Hare, J. Paul, Cappuccio, F.P.   +51 more
core   +1 more source

Autoimmune Comorbidities as Modifiers of Phenotypic Heterogeneity in Facioscapulohumeral Dystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral dystrophy type 1 (FSHD1) shows clinical heterogeneity that is only partly explained by D4Z4 repeat unit (RU) size. Although immune and inflammatory mechanisms may contribute to disease variability, the prevalence and clinical impact of autoimmune diseases in FSHD remain unclear.
Jonathan Pini, Giulia Tammam, Andra Ezaru, Manuela Gambella, Benoît Sanson, Luisa Villa, Michele Cavalli, Mihai‐Bogdan Ioncea, Angela Puma, Sabrina Sacconi   +9 more
wiley   +1 more source

The Presence of Telomere Fusion in Sporadic Colon Cancer Independently of Disease Stage, TP53/KRAS Mutation Status, Mean Telomere Length, and Telomerase Activity

Neoplasia: An International Journal for Oncology Research, 2014
Defects in telomere maintenance can result in telomere fusions that likely play a causative role in carcinogenesis by promoting genomic instability. However, this proposition remains to be fully understood in human colon carcinogenesis.
Hiromi Tanaka, Matthew J. Beam, Kevin Caruana   +2 more
doaj   +1 more source