Results 71 to 80 of about 116,824 (219)

Dysfunctional telomeres in primary cells from Fanconi anemia FANCD2 patients [PDF]

, 2012
© 2012 Joksic et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium ...
Marija Guc-Scekic, Juan P Trujillo, Maja Zivkovic, Gordana Joksic, Predrag Slijepcevic, Slijepcevic, P, Trujillo, JP, Surrallés i Calonge, Jordi, Petrovic, S, Zivkovic, Maja, Joksic, I, Trujillo Quintero, Juan Pablo, Joksic, G, Jordi Surralles, Aleksandra Stankovic, Vujic, D, Zivkovic, M, Vujic, Dragana, Joksic, Gordana, Andreja Leskovac, Joksic, Ivana, Surralles, J, Guc-Scekic, Marija, Maryam Ojani, Ojani, M, Ojani, Maryam, Dragana Vujic, Slijepcevic, Pedrag, Petrovic, Sandra, Sandra Petrovic, Guc-Scekic, M, Stankovic, A, Stankovic, Aleksandra, Leskovac, Andreja, Ivana Joksic, Leskovac, A   +35 more
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Telomeres in disease [PDF]

F1000 Medicine Reports, 2012
Telomeres and telomere repair are basic molecular features of cells possessing linear DNA chromosomes and defects in them result in various diseases. This review examines recent advances in understanding these diseases, particularly at a molecular level, and in relating telomere dysfunction to clinical diseases.
Calado, Rodrigo, Young, Neal
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Characterization and consequences of Telomere replication gone awry [PDF]

, 2008
Telomeres, the ends of linear eukaryotic chromosomes, pose several unique challenges to genome stability. My thesis work is concerned with the difficulties the replication machinery encounters when attempting to replicate telomeres, and with possible ...
Rog, O., Rog, O
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Epiphenomenon of telomere lengths : lessons from ulcerative colitis [PDF]

, 2012
We read with great interest the article by Jones et al detailing TERC polymorphisms, longer telomeres and increased risk of colorectal cancer (CRC).1 Indeed, it is accepted that shorter telomere lengths (measured from peripheral leucocytes) have been ...
Arasaradnam, Ramesh P., Nwokolo, Chuka U.   +1 more
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DNA methylation and telomere length in 2–5 year olds with intrauterine preeclampsia exposure: a P4 sub-study

Clinical Epigenetics
Preeclampsia is a hypertensive disorder of pregnancy characterised by new onset hypertension at ≥ 20 weeks’ gestation accompanied by maternal organ dysfunction and/ or fetal compromise.
Jason P. Ross, Benjamin J. Varley, Jadon K. Wells, Robyn P. L. Yeh, Hilda A. Pickett, Raja S. Vasireddy, Lynne Roberts, Greg Davis, Amanda Henry, Maria E. Craig, Megan L. Gow   +10 more
doaj   +1 more source

Rapid telomere motions in live human cells analyzed by highly time-resolved microscopy

Epigenetics & Chromatin, 2008
Background Telomeres cap chromosome ends and protect the genome. We studied individual telomeres in live human cancer cells. In capturing telomere motions using quantitative imaging to acquire complete high-resolution three-dimensional datasets every ...
Wang Xueying, Kam Zvi, Carlton Peter M, Xu Lifeng, Sedat John W, Blackburn Elizabeth H   +5 more
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Depleting components of the THO complex causes increased telomere length by reducing the expression of the telomere-associated protein Rif1p. [PDF]

PLoS ONE, 2012
Telomere length is regulated mostly by proteins directly associated with telomeres. However, genome-wide analysis of Saccharomyces cerevisiae mutants has revealed that deletion of Hpr1p, a component of the THO complex, also affects telomere length.
Tai-Yuan Yu, Chen-Yi Wang, Jing-Jer Lin
doaj   +1 more source

The Ruminant Telomere-to-Telomere (RT2T) Consortium

Nature Genetics
Telomere-to-telomere (T2T) assemblies reveal new insights into the structure and function of the previously 'invisible' parts of the genome and allow comparative analyses of complete genomes across entire clades. We present here an open collaborative effort, termed the 'Ruminant T2T Consortium' (RT2T), that aims to generate complete diploid assemblies ...
Kalbfleisch, Theodore, Mckay, Stephanie, Murdoch, Brenda, Adelson, David, Almansa-Villa, Diego, Becker, Gabrielle, Beckett, Linda, Benítez-Galeano, María José, Biase, Fernando, Casey, Theresa, Chuong, Edward, Clark, Emily, Clarke, Shannon, Cockett, Noelle, Couldrey, Christine, Davis, Brian, Elsik, Christine, Faraut, Thomas, Gao, Yahui, Genet, Carine, Grady, Patrick, Green, Jonathan, Green, Richard, Guan, Dailu, Hagen, Darren, Hartley, Gabrielle, Heaton, Mike, Hoyt, Savannah, Huang, Wen, Jarvis, Erich, Kalleberg, Jenna, Khatib, Hasan, Koepfi, Klaus-Peter, Koltes, James, Koren, Sergey, Kuehn, Christa, Leeb, Tosso, Leonard, Alexander, Liu, George, Low, Wai Yee, Mcconnell, Hunter, Mcrae, Kathryn, Miga, Karen, Mousel, Michelle, Neibergs, Holly, Olagunju, Temitayo, Pennell, Matt, Petry, Bruna, Pewsner, Mirjam, Phillippy, Adam, Pickett, Brandon, Pineda, Paulene, Potapova, Tamara, Rachagani, Satyanarayana, Rhie, Arang, Rijnkels, Monique, Robic, Annie, Rodriguez Osorio, Nelida, Safonova, Yana, Schettini, Gustavo, Schnabel, Robert, Sirpu Natesh, Nagabhishek, Stegemiller, Morgan, Storer, Jessica, Stothard, Paul, Stull, Caleb, Tosser-Klopp, Gwenola, Traglia, Germán, Tuggle, Christopher, van Tassell, Curtis, Watson, Corey, Weikard, Rosemarie, Wimmers, Klaus, Xie, Shangqian, Yang, Liu, Smith, Timothy, O’neill, Rachel, Rosen, Benjamin   +77 more
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From organ to cell: Multi-level telomere length assessment in patients with idiopathic pulmonary fibrosis.

PLoS ONE, 2020
RationaleA subset of patients with idiopathic pulmonary fibrosis (IPF) contains short leukocyte telomeres or telomere related mutations. We previously showed that alveolar type 2 cells have short telomeres in fibrotic lesions.
Aernoud A van Batenburg, Karin M Kazemier, Matthijs F M van Oosterhout, Joanne J van der Vis, Hendrik W van Es, Jan C Grutters, Roel Goldschmeding, Coline H M van Moorsel   +7 more
doaj   +1 more source

Analysis of telomere maintenance in artemis defective human cell lines [PDF]

, 2009
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Telomeres are physical ends of chromosomes consisting of (TTAGGG)n DNA sequence and a specialized set of proteins that protect chromosomal ends from ...
Yasaei, Hemad
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