Results 71 to 80 of about 130,635 (210)

Rapid telomere motions in live human cells analyzed by highly time-resolved microscopy

Epigenetics & Chromatin, 2008
Background Telomeres cap chromosome ends and protect the genome. We studied individual telomeres in live human cancer cells. In capturing telomere motions using quantitative imaging to acquire complete high-resolution three-dimensional datasets every ...
Wang Xueying, Kam Zvi, Carlton Peter M, Xu Lifeng, Sedat John W, Blackburn Elizabeth H   +5 more
doaj   +1 more source

Early-Life Telomere Dynamics Differ between the Sexes and Predict Growth in the Barn Swallow (Hirundo rustica). [PDF]

PLoS ONE, 2015
Telomeres are conserved DNA-protein structures at the termini of eukaryotic chromosomes which contribute to maintenance of genome integrity, and their shortening leads to cell senescence, with negative consequences for organismal functions.
Marco Parolini, Andrea Romano, Lela Khoriauli, Solomon G Nergadze, Manuela Caprioli, Diego Rubolini, Marco Santagostino, Nicola Saino, Elena Giulotto   +8 more
doaj   +1 more source

Exercise, Telomeres, and Cancer: “The Exercise-Telomere Hypothesis” [PDF]

Frontiers in Physiology, 2018
Telomeres are genomic complex at the end of chromosomes that protects the DNA and telomere length (TL) is related to several age-related diseases, lifespan, and cancer. On the other hand, cancer is a multifactorial disease that is responsible for reduce the quality of life and kills millions of people every year. Both, shorter TL and cancer are related
Nikitas N. Nomikos, Pantelis T. Nikolaidis, Caio V. Sousa, Apostolos E. Papalois, Thomas Rosemann, Beat Knechtle, Beat Knechtle   +6 more
openaire   +5 more sources

TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres. [PDF]

, 2011
Shorter telomeres have been associated with increased risk of malignancy, including colorectal cancer (CRC). Telomere length is heritable and may be an intermediate phenotype linked to genetic susceptibility to ...
Tomlinson, IP, A M Jones, Beggs, A. D., Jones, A. M., M Walker, Jones, A.M., Dunlop, MG, Beggs, A.D., Tenesa, A., A D Beggs, Kerr, D, A Zauber, A Tenesa, Hodgson, S. V., Walker, M., M Bertagnolli, R Midgley, Carvajal-Carmona, L, Dunlop, Malcolm, Tenesa, Albert, Tenesa, A, Kerr, D., Jones, AM, Beggs, AD, M G Dunlop, Jones, A M, Tomlinson, IPM, Carvajal-Carmona, L., Campbell, H.; id_orcid, Tomlinson, I P M, S Ballereau, Tomlinson, I. P. M., Zauber, A., S V Hodgson, Campbell, H, H Campbell, Farrington, S., Hodgson, SV, Ballereau, S., Campbell, H., Walker, M, S Farrington, I P M Tomlinson, Dunlop, M G, K Howarth, Farrington, S.; id_orcid, Howarth, K., Ballereau, S, Hodgson, S.V., Bertagnolli, M., Tomlinson, I.P., Beggs, A D; id_orcid, Midgley, R., D Kerr, Bertagnolli, M, L Carvajal-Carmona, Hodgson, S V, Dunlop, M. G., Midgley, R, Zauber, A, Howarth, K, Farrington, S   +61 more
core   +1 more source

DNA methylation and telomere length in 2–5 year olds with intrauterine preeclampsia exposure: a P4 sub-study

Clinical Epigenetics
Preeclampsia is a hypertensive disorder of pregnancy characterised by new onset hypertension at ≥ 20 weeks’ gestation accompanied by maternal organ dysfunction and/ or fetal compromise.
Jason P. Ross, Benjamin J. Varley, Jadon K. Wells, Robyn P. L. Yeh, Hilda A. Pickett, Raja S. Vasireddy, Lynne Roberts, Greg Davis, Amanda Henry, Maria E. Craig, Megan L. Gow   +10 more
doaj   +1 more source

From organ to cell: Multi-level telomere length assessment in patients with idiopathic pulmonary fibrosis.

PLoS ONE, 2020
RationaleA subset of patients with idiopathic pulmonary fibrosis (IPF) contains short leukocyte telomeres or telomere related mutations. We previously showed that alveolar type 2 cells have short telomeres in fibrotic lesions.
Aernoud A van Batenburg, Karin M Kazemier, Matthijs F M van Oosterhout, Joanne J van der Vis, Hendrik W van Es, Jan C Grutters, Roel Goldschmeding, Coline H M van Moorsel   +7 more
doaj   +1 more source

Genome assembly in the telomere-to-telomere era

Nature Reviews Genetics
De novo assembly is the process of reconstructing the genome sequence of an organism from sequencing reads. Genome sequences are essential to biology, and assembly has been a central problem in bioinformatics for four decades. Until recently, genomes were typically assembled into fragments of a few megabases at best but technological advances in long ...
Heng Li, Richard Durbin
openaire   +4 more sources

Effects of BRCA2 deficiency on telomere recombination in non-ALT and ALT cells [PDF]

, 2011
This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2011 Sapir et al.Background: Recent studies suggest that BRCA2 affects telomere maintenance.
Slijepcevic, P, Yaghoub Gozaly-Chianea, Sainu Ravindran, Ravindran, S, Yasaei, H, Ester Sapir, Predrag Slijepcevic, Suliman Al-Wahiby, Hemad Yasaei, Gozaly-Chianea, Y, Sapir, E, Al-Wahiby, S   +11 more
core   +1 more source

Investigation of telomere maintenance in BRCA2 defective mammalian cell lines [PDF]

, 2014
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel UniversityBRCA2 is a highly penetrant breast cancer predisposing gene.
Gozaly Chianea, Yaghoub
core   +3 more sources

Telomere erosion in memory T cells induced by telomerase inhibition at the site of antigenic challenge in vivo. [PDF]

, 2004
The extent of human memory T cell proliferation, differentiation, and telomere erosion that occurs after a single episode of immune challenge in vivo is unclear.
Beverley, PCL, Catherine H. Orteu, Peter C.L. Beverley, Graham R. Foster, Jackson, SE, Fletcher, JM, Reed, JR, Maria Vieira D. Soares, Soares, MVD, Salmon, Michael, Katie E. Birch, Orteu, CH, John R. Reed, Mike Salmon, Birch, KE, Milica Vukmanovic-Stejic, Jean M. Fletcher, Arne N. Akbar, Soarees, MV, Akbar, AN, Joanne E. Cook, Cook, JE, Foster, GR, Salmon, M, Vukmanovic-Stejic, M, Malcolm H.A. Rustin, Rustin, MHA, Sarah E. Jackson   +27 more
core   +1 more source