Results 51 to 60 of about 130,635 (210)

Evaluation of a screening protocol for telomere biology disorders in individuals with interstitial lung disease undergoing lung transplant evaluation

ERJ Open Research
Background Because of the potential for extrapulmonary disease, it is important for lung transplant programmes to identify telomere biology disorder (TBD)-related interstitial lung disease (ILD).
Daisy Zhu, Namrata B. Patel, Allyson M. Pishko, Ethan M. Weinberg, Tanaka I. Takako, Staci Kallish, F. Bradley Johnson, Daria V. Babushok, Andrew M. Courtwright   +8 more
doaj   +1 more source

Telomeres and telomerase [PDF]

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2004
Telomeres are the protective DNA–protein complexes found at the ends of eukaryotic chromosomes. Telomeric DNA consists of tandem repeats of a simple, often G–rich, sequence specified by the action of telomerase, and complete replication of telomeric DNA requires telomerase.
Simon R W L, Chan, Elizabeth H, Blackburn   +1 more
openaire   +2 more sources

Senescence, Telomere Shortening and Telomere Maintenance [PDF]

Cancer Biology & Therapy, 2002
No Abstract Available Commentary to: Title: Telomerase Protects Cancer-Prone Human Cells from Chromosomal Instability and Spontaneous Immortalization Authors: Lynne W. Elmore, Kristi C. Turner, Lauren S. Gollahon, Melissa R. Landon, Colleen K. Jackson-Cook and Shawn E.
openaire   +2 more sources

Cell cycle-dependent modification of Pot1 and its effects on telomere function [PDF]

, 2009
Telomere functions are tightly controlled throughout the cell cycle to allow telomerase access while suppressing a bona fide DNA damage response (DDR) at linear chromosome ends.
Kuznetsov, V, Kuznetsov, V.
core  

Telomeres in Space

Aging Cell
ABSTRACTRecent studies have reported that the spaceflight environment lengthens leukocyte telomeres. We propose that this baffling finding reflects changes in the composition of leukocyte subsets rather than an actual increase in telomere length within individual leukocytes.
Abraham Aviv, Simon Verhulst
openaire   +2 more sources

ZNF827 is a single-stranded DNA binding protein that regulates the ATR-CHK1 DNA damage response pathway

Nature Communications
The ATR-CHK1 DNA damage response pathway becomes activated by the exposure of RPA-coated single-stranded DNA (ssDNA) that forms as an intermediate during DNA damage and repair, and as a part of the replication stress response. Here, we identify ZNF827 as
Sile F. Yang, Christopher B. Nelson, Jadon K. Wells, Madushan Fernando, Robert Lu, Joshua A. M. Allen, Lisa Malloy, Noa Lamm, Vincent J. Murphy, Joel P. Mackay, Andrew J. Deans, Anthony J. Cesare, Alexander P. Sobinoff, Hilda A. Pickett   +13 more
doaj   +1 more source

Human SKI component SKIV2L regulates telomeric DNA-RNA hybrids and prevents telomere fragility

iScience
Summary: Super killer (SKI) complex is a well-known cytoplasmic 3′–5′ mRNA decay complex that functions with the exosome to degrade excessive and aberrant mRNAs, is implicated with the extraction of mRNA at stalled ribosomes, tackling aberrant ...
Emilia Herrera-Moyano, Rosa Maria Porreca, Lepakshi Ranjha, Eleni Skourti, Roser Gonzalez-Franco, Emmanouil Stylianakis, Ying Sun, Ruihan Li, Almutasem Saleh, Alex Montoya, Holger Kramer, Jean-Baptiste Vannier   +11 more
doaj   +1 more source

Telomere-related genetic variants discovered in IPF cases by WES.

, 2020
Telomere-related genetic variants discovered in IPF cases by WES.
Joanne J. van der Vis (4720647), Roel Goldschmeding (50835), Matthijs F. M. van Oosterhout (4720653), Hendrik W. van Es (8259684), Aernoud A. van Batenburg (4720650), Karin M. Kazemier (8259681), Coline H. M. van Moorsel (8259690), Jan C. Grutters (8259687)   +7 more
core   +1 more source

Suv4-20h abrogation enhances telomere elongation during reprogramming and confers a higher tumorigenic potential to iPS cells [PDF]

, 2011
Reprogramming of adult differentiated cells to induced pluripotent stem cells (iPS) cells has been achieved by over-expression of specific transcription factors.
Maria A. Blasco, Maria A Blasco, Marión, Rosa M., Ortega Sagrario, Marión Rosa M., Schotta Gunnar, Blasco Maria A., Schotta, Gunnar, Rosa M. Marión, Blasco, Maria A., Gunnar Schotta, Sagrario Ortega, Rosa M Marión, Ortega, Sagrario   +13 more
core   +1 more source

The Presence of Telomere Fusion in Sporadic Colon Cancer Independently of Disease Stage, TP53/KRAS Mutation Status, Mean Telomere Length, and Telomerase Activity

Neoplasia: An International Journal for Oncology Research, 2014
Defects in telomere maintenance can result in telomere fusions that likely play a causative role in carcinogenesis by promoting genomic instability. However, this proposition remains to be fully understood in human colon carcinogenesis.
Hiromi Tanaka, Matthew J. Beam, Kevin Caruana   +2 more
doaj   +1 more source