Results 51 to 60 of about 116,824 (219)

Telomere-to-telomere genome assembly of the Taihu goose

, 2023
Our study presents the pioneering assembly of a high-quality Taihu goose genome at the Telomere-to-Telomere (T2T) level. By employing advanced sequencing technologies, including Pacific Biosciences HiFi reads, Oxford Nanopore long reads, Illumina short ...
Hongchang Zhao (17625645)
core   +1 more source

ZNF827 is a single-stranded DNA binding protein that regulates the ATR-CHK1 DNA damage response pathway

Nature Communications
The ATR-CHK1 DNA damage response pathway becomes activated by the exposure of RPA-coated single-stranded DNA (ssDNA) that forms as an intermediate during DNA damage and repair, and as a part of the replication stress response. Here, we identify ZNF827 as
Sile F. Yang, Christopher B. Nelson, Jadon K. Wells, Madushan Fernando, Robert Lu, Joshua A. M. Allen, Lisa Malloy, Noa Lamm, Vincent J. Murphy, Joel P. Mackay, Andrew J. Deans, Anthony J. Cesare, Alexander P. Sobinoff, Hilda A. Pickett   +13 more
doaj   +1 more source

ATM Kinase Is Required for Telomere Elongation in Mouse and Human Cells

Cell Reports, 2015
Short telomeres induce a DNA damage response, senescence, and apoptosis, thus maintaining telomere length equilibrium is essential for cell viability. Telomerase addition of telomere repeats is tightly regulated in cells.
Stella Suyong Lee, Craig Bohrson, Alexandra Mims Pike, Sarah Jo Wheelan, Carol Widney Greider   +4 more
doaj   +1 more source

Evaluation of a screening protocol for telomere biology disorders in individuals with interstitial lung disease undergoing lung transplant evaluation

ERJ Open Research
Background Because of the potential for extrapulmonary disease, it is important for lung transplant programmes to identify telomere biology disorder (TBD)-related interstitial lung disease (ILD).
Daisy Zhu, Namrata B. Patel, Allyson M. Pishko, Ethan M. Weinberg, Tanaka I. Takako, Staci Kallish, F. Bradley Johnson, Daria V. Babushok, Andrew M. Courtwright   +8 more
doaj   +1 more source

Telomeres in Space

Aging Cell
ABSTRACTRecent studies have reported that the spaceflight environment lengthens leukocyte telomeres. We propose that this baffling finding reflects changes in the composition of leukocyte subsets rather than an actual increase in telomere length within individual leukocytes.
Abraham Aviv, Simon Verhulst
openaire   +2 more sources

Telomere-to-telomere (T2T) genome of the model plant Physcomitrium patens

, 2023
An exemplary assembly of the P. patens nuclear genome, which incorporates telomeres and centromere regions, thereby establishing it as the first telomere-to-telomere (T2T) genome in a nonseed plant.
Shijun Zhao (15687284)
core   +1 more source

Telomeres and telomerase [PDF]

Genes & Development, 1999
Telomeres are in the spotlight of modern biology. Whether the subject at hand is cancer, gene regulation, organismal aging, or the cloning of mammals, much seems to depend on what happens at the ends of chromosomes. Because glamorous hypotheses often persist without experimental support, it is important to ask ourselves what we really know about ...
M A, Blasco, S M, Gasser, J, Lingner
openaire   +2 more sources

Telomere erosion in memory T cells induced by telomerase inhibition at the site of antigenic challenge in vivo. [PDF]

, 2004
The extent of human memory T cell proliferation, differentiation, and telomere erosion that occurs after a single episode of immune challenge in vivo is unclear.
Beverley, PCL, Catherine H. Orteu, Peter C.L. Beverley, Graham R. Foster, Jackson, SE, Fletcher, JM, Reed, JR, Maria Vieira D. Soares, Soares, MVD, Salmon, Michael, Katie E. Birch, Orteu, CH, John R. Reed, Mike Salmon, Birch, KE, Milica Vukmanovic-Stejic, Jean M. Fletcher, Arne N. Akbar, Beverley, Peter, Soarees, MV, Akbar, AN, Joanne E. Cook, Soares, MV, Rustin, MH, Cook, JE, Beverley, PC, Foster, GR, Salmon, M, Vukmanovic-Stejic, M, Malcolm H.A. Rustin, Rustin, MHA, Sarah E. Jackson   +31 more
core   +1 more source

Human SKI component SKIV2L regulates telomeric DNA-RNA hybrids and prevents telomere fragility

iScience
Summary: Super killer (SKI) complex is a well-known cytoplasmic 3′–5′ mRNA decay complex that functions with the exosome to degrade excessive and aberrant mRNAs, is implicated with the extraction of mRNA at stalled ribosomes, tackling aberrant ...
Emilia Herrera-Moyano, Rosa Maria Porreca, Lepakshi Ranjha, Eleni Skourti, Roser Gonzalez-Franco, Emmanouil Stylianakis, Ying Sun, Ruihan Li, Almutasem Saleh, Alex Montoya, Holger Kramer, Jean-Baptiste Vannier   +11 more
doaj   +1 more source

Early-Life Telomere Dynamics Differ between the Sexes and Predict Growth in the Barn Swallow (Hirundo rustica). [PDF]

PLoS ONE, 2015
Telomeres are conserved DNA-protein structures at the termini of eukaryotic chromosomes which contribute to maintenance of genome integrity, and their shortening leads to cell senescence, with negative consequences for organismal functions.
Marco Parolini, Andrea Romano, Lela Khoriauli, Solomon G Nergadze, Manuela Caprioli, Diego Rubolini, Marco Santagostino, Nicola Saino, Elena Giulotto   +8 more
doaj   +1 more source