Results 51 to 60 of about 128,303 (302)

A mechanistic investigation into candidate markers of telomere-induced senescence in normal human epidermal keratinocytes [PDF]

, 2014
PhDTelomere dysfunction is one mechanism of cellular and tissue ageing. Dysfunctional telomeres in fibroblasts are recognised as DNA double-strand breaks (DSBs) and trigger the DNA damage pathway of senescence.
dos Santos Soares Martins de Castro, Alicia Maria
core   +4 more sources

Evaluation of a screening protocol for telomere biology disorders in individuals with interstitial lung disease undergoing lung transplant evaluation

ERJ Open Research
Background Because of the potential for extrapulmonary disease, it is important for lung transplant programmes to identify telomere biology disorder (TBD)-related interstitial lung disease (ILD).
Daisy Zhu, Namrata B. Patel, Allyson M. Pishko, Ethan M. Weinberg, Tanaka I. Takako, Staci Kallish, F. Bradley Johnson, Daria V. Babushok, Andrew M. Courtwright   +8 more
doaj   +1 more source

Telomeres and telomerase [PDF]

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2004
Telomeres are the protective DNA–protein complexes found at the ends of eukaryotic chromosomes. Telomeric DNA consists of tandem repeats of a simple, often G–rich, sequence specified by the action of telomerase, and complete replication of telomeric DNA requires telomerase.
Simon R W L, Chan, Elizabeth H, Blackburn   +1 more
openaire   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China. [PDF]

, 2013
A recent genome-wide association study of lung cancer among never-smoking females in Asia demonstrated that the rs2736100 polymorphism in the TERT-CLPTM1L locus on chromosome 5p15.33 was strongly and significantly associated with risk of adenocarcinoma ...
Xiang, Y, Hu W, Ji, BT, Wei Hu, Cai, Q, Chanock, S, Berndt S, Lan Qing, Hosgood, HD, H Dean Hosgood, Hu Wei, Kim Christopher, Cai Qiuyin, Shu X, Richard Cawthon, Barone-Adesi Francesco, Rothman Nathaniel, Cawthon R, Gao, Y, Sonja Berndt, Zheng Wei, Wong-Ho Chow, Chow WH, Stephen Chanock, BARONE ADESI, Francesco, Zheng W, Francesco Barone-Adesi, Bassig B, Yutang Gao, Berndt Sonja, Kim, C, Lan Q, Gao Y, Bryan Bassig, Hu, W, Rothman N., Berndt, S, Cawthon, R, Xiang Yongbin, Kim C, Christopher Kim, Cai Q, Yongbin Xiang, Xiaoou Shu, Bassig, B, Chanock Stephen, Chanock S, Shu Xiaoou, Chow Wong-Ho, Ji Bu-Tian, Barone-Adesi, F, Gao Yutang, Bassig Bryan, Shu, X, Qing Lan, Qiuyin Cai, Zheng, W, Rothman, N, Nathaniel Rothman, Hosgood H. Dean, Wei Zheng, Bu-Tian Ji, Chow, WH, Ji BT, Hosgood HD 3rd, Cawthon Richard, Xiang Y, Lan, Q   +67 more
core   +2 more sources

ATM Kinase Is Required for Telomere Elongation in Mouse and Human Cells

Cell Reports, 2015
Short telomeres induce a DNA damage response, senescence, and apoptosis, thus maintaining telomere length equilibrium is essential for cell viability. Telomerase addition of telomere repeats is tightly regulated in cells.
Stella Suyong Lee, Craig Bohrson, Alexandra Mims Pike, Sarah Jo Wheelan, Carol Widney Greider   +4 more
doaj   +1 more source

Senescence, Telomere Shortening and Telomere Maintenance [PDF]

Cancer Biology & Therapy, 2002
No Abstract Available Commentary to: Title: Telomerase Protects Cancer-Prone Human Cells from Chromosomal Instability and Spontaneous Immortalization Authors: Lynne W. Elmore, Kristi C. Turner, Lauren S. Gollahon, Melissa R. Landon, Colleen K. Jackson-Cook and Shawn E.
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Suv4-20h abrogation enhances telomere elongation during reprogramming and confers a higher tumorigenic potential to iPS cells [PDF]

, 2011
Reprogramming of adult differentiated cells to induced pluripotent stem cells (iPS) cells has been achieved by over-expression of specific transcription factors.
Maria A. Blasco, Maria A Blasco, Marión, Rosa M., Ortega Sagrario, Marión Rosa M., Schotta Gunnar, Blasco Maria A., Schotta, Gunnar, Rosa M. Marión, Blasco, Maria A., Gunnar Schotta, Sagrario Ortega, Rosa M Marión, Ortega, Sagrario   +13 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source