Shorter juvenile telomere length is associated with higher survival to spawning in migratory Atlantic salmon [PDF]
, 2017 The risk of mortality associated with a long-distance migration will depend on an animal's physiological state, as well as the prevailing ecological conditions.
Armstrong, John D. +6 more
core +1 more source
Sir4 Deficiency Reverses Cell Senescence by Sub-Telomere Recombination
Cells, 2021 Telomere shortening results in cellular senescence and the regulatory mechanisms remain unclear. Here, we report that the sub-telomere regions facilitate telomere lengthening by homologous recombination, thereby attenuating senescence in yeast ...
Jun Liu +4 more
doaj +1 more source
The impact of oxidative DNA damage and stress on telomere homeostasis.
Mechanisms of Ageing and Development, 2019 Telomeres are dynamic nucleoprotein-DNA structures that cap and protect linear chromosome ends. Because telomeres shorten progressively with each replication, they impose a functional limit on the number of times a cell can divide.
Ryan P Barnes +2 more
semanticscholar +1 more source
Measuring vertebrate telomeres: applications and limitations [PDF]
, 2004 Telomeres are short tandem repeated sequences of DNA found at the ends of eukaryotic chromosomes that function in stabilizing chromosomal end integrity.
Allsopp RC +27 more
core +1 more source
A marker of biological ageing predicts adult risk preference in European starlings, Sturnus vulgaris [PDF]
, 2018 Why are some individuals more prone to gamble than others? Animals often show preferences between 2 foraging options with the same mean reward but different degrees of variability in the reward, and such risk preferences vary between individuals ...
Andrews, Clare +5 more
core +3 more sources
Telomeric recombination induced by dysfunctional telomeres
Molecular Biology of the Cell, 2011 Telomere maintenance is essential for cellular immortality, and most cancer cells maintain their telomeres through the enzyme telomerase. Telomeres and telomerase represent promising anticancer targets. However, 15% of cancer cells maintain their telomeres through alternative recombination-based mechanisms, and previous analyses showed that ...
Brault, Marie Eve, Autexier, Chantal
openaire +2 more sources
Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence
EMBO Journal, 2019 Ageing is the biggest risk factor for cardiovascular disease. Cellular senescence, a process driven in part by telomere shortening, has been implicated in age‐related tissue dysfunction.
Rhys K. Anderson +33 more
semanticscholar +1 more source
Telomeric RNAs are essential to maintain telomeres [PDF]
Nature Communications, 2016 AbstractTelomeres are transcribed generating long non-coding RNAs known as TERRA. Deciphering the role of TERRA has been one of the unsolved issues of telomere biology in the past decade. This has been, in part, due to lack of knowledge on the TERRA loci, thus preventing functional genetic studies. Here, we describe that long non-coding RNAs with TERRA
Juan José Montero +3 more
openaire +4 more sources
Association of telomere instability with senescence of porcine cells
BMC Cell Biology, 2012 Background Telomeres are essential for the maintenance of genomic stability, and telomere dysfunction leads to cellular senescence, carcinogenesis, aging, and age-related diseases in humans. Pigs have become increasingly important large animal models for
Ji Guangzhen +4 more
doaj +1 more source
The JIL-1 kinase affects telomere expression in the different telomere domains of Drosophila. [PDF]
PLoS ONE, 2013 In Drosophila, the non-LTR retrotransposons HeT-A, TART and TAHRE build a head-to-tail array of repetitions that constitute the telomere domain by targeted transposition at the end of the chromosome whenever needed. As a consequence, Drosophila telomeres
Rute Silva-Sousa, Elena Casacuberta
doaj +1 more source