Analysis of telomere length and function in radiosensitive mouse and human cells in response to DNA-PKcs inhibition [PDF]
, 2013 © 2013 Yasaei et al.; licensee BioMed Central Ltd.This article has been made available through the Brunel Open Access Publishing Fund.Telomeres, the physical ends of chromosomes, play an important role in preserving genomic integrity.
Slijepcevic, P +5 more
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Association of telomere instability with senescence of porcine cells
BMC Cell Biology, 2012 Background Telomeres are essential for the maintenance of genomic stability, and telomere dysfunction leads to cellular senescence, carcinogenesis, aging, and age-related diseases in humans. Pigs have become increasingly important large animal models for
Ji Guangzhen +4 more
doaj +1 more source
Telomeres susceptibility to environmental arsenic exposure: Shortening or lengthening?
Frontiers in Public Health, 2023 Maintaining telomere length plays a crucial role in regulating cellular life span. Telomere lengthening or shortening is one of the important biomarkers which could predict the preceding or present diseases. Meanwhile, the impact of environmental arsenic
Kyi Mar Wai +5 more
doaj +1 more source
EMBO reports, 2002 Telomeres are protein–DNA complexes that cap chromosome ends and protect them from being recognized and processed as DNA breaks. Loss of capping function results in genetic instability and loss of cellular viability. The emerging view is that maintenance of an appropriate telomere structure is essential for function. Structural information on telomeric
Daniela, Rhodes +4 more
openaire +2 more sources
Telomere length comparison between oral cells and blood cells among neonates
The Turkish Journal of Pediatrics, 2019 Telomere length, measured from blood cells, is commonly used as the standard telomere length of the whole body. The relationship between blood telomere length and oral telomere length is still unclear, especially among neonates.
Mandar Bhattacharya +2 more
doaj +1 more source
Structural basis for Rap1-Rif1-Rif2 assembly : insights into budding yeast telomere architecture and functions [PDF]
, 2012 Telomeres form the ends of eukaryotic linear chromosomes and are composed of specialized nucleoprotein complexes. They have been the subject of intense investigation over several decades, as telomere dysfunction has been associated with genome ...
Tianlai, Shi
core +1 more source
Identification of Neuroblastoma Subgroups Based on Three-Dimensional Telomere Organization
Translational Oncology, 2016 Using 3D telomere quantitative fluorescence in situ hybridization, we determined the 3D telomere organization of 74 neuroblastoma tissue samples. Hierarchical cluster analysis of the measured telomere parameters identified three subgroups from our ...
Alexandra Kuzyk +2 more
doaj +1 more source
The effect of chemotherapeutic agents on telomere length maintenance in breast cancer cell lines [PDF]
, 2014 Copyright @ 2014 the authors. This article is made available through the Brunel Open Access Publishing Fund. It is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution ...
Slijepcevic, P +9 more
core +1 more source
Telomere-to-telomere assemblies and annotation data for Gossypium raimondii
, 2023 Telomere-to-telomere assemblies and annotation data for Gossypium ...
Gai Huang (12980537)
core +1 more source
Telomere tracking from birth to adulthood and residential traffic exposure
BMC Medicine, 2017 Background Telomere attrition is extremely rapid during the first years of life, while lifestyle during adulthood exerts a minor impact. This suggests that early life is an important period in the determination of telomere length.
Esmée M. Bijnens +9 more
doaj +1 more source