The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age [PDF]
Nature Communications, 2017 Repeated cell divisions induce DNA damage in haematopoietic stem cells (HSC) and telomeres are sensitive to this damage. Here, the authors show in murine HSCs that the telomere binding protein POT1a inhibited the production of reactive oxygen species ...
Kentaro Hosokawa +7 more
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Duplex Telomere-Binding Proteins in Fungi With Canonical Telomere Repeats: New Lessons in the Rapid Evolution of Telomere Proteins [PDF]
Frontiers in Genetics, 2021 The telomere protein assemblies in different fungal lineages manifest quite profound structural and functional divergence, implying a high degree of flexibility and adaptability.
Neal F. Lue, Neal F. Lue
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Tay1 Protein, a Novel Telomere Binding Factor from Yarrowia lipolytica [PDF]
Journal of Biological Chemistry, 2020 Inspection of the complete genome of the yeast Yarrowia lipolytica for the presence of genes encoding homologues of known telomere-binding proteins surprisingly revealed no counterparts of typical yeast Myb domain-containing telomeric factors including Rap1 or Taz1.
Ľubomír Tomáška +6 more
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Telomere DNA recognition in Saccharomycotina yeast: potential lessons for the co-evolution of ssDNA and dsDNA-binding proteins and their target sites [PDF]
Frontiers in Genetics, 2015 In principle, alterations in the telomere repeat sequence would be expected to disrupt the protective nucleoprotein complexes that confer stability to chromosome ends, and hence relatively rare events in evolution.
Neal F. Lue +2 more
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The telomere binding protein TRF2 induces chromatin compaction. [PDF]
PLoS ONE, 2011 Mammalian telomeres are specialized chromatin structures that require the telomere binding protein, TRF2, for maintaining chromosome stability. In addition to its ability to modulate DNA repair activities, TRF2 also has direct effects on DNA structure ...
Asmaa M Baker +6 more
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Telomere-binding proteins play roles in control of replication timing [PDF]
Cell Cycle, 2012 Comment on: Tazumi A, et al. Genes Dev 2012; 26:2050-62.
Atsutoshi Tazumi, Hisao Masukata
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The Telomere-Binding Protein Tbf1 Demarcates snoRNA Gene Promoters in Saccharomyces cerevisiae [PDF]
Molecular Cell, 2010 Small nucleolar RNAs (snoRNAs) play a key role in ribosomal RNA biogenesis, yet factors controlling their expression are unknown. We found that the majority of Saccharomyces snoRNA promoters display an aRCCCTaa sequence motif at the upstream border of a TATA-containing nucleosome-free region.
Milena Preti +9 more
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A single‐stranded telomere binding protein in the nematode Caenorhabditis elegans [PDF]
FEBS Letters, 2001 We identified and characterized a protein (STB‐1) from the nuclear extract of Caenorhabditis elegans that specifically binds single‐stranded telomere DNA sequences, but not the corresponding RNA sequences. STB‐1 binding activity is specific to the nematode telomere, but not to the human or plant telomere.
Soo Young Yi +5 more
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Electronic Journal of Biotechnology, 2018 Background: TRF2 (telomeric repeat binding factor 2) is an essential component of the telomere-binding protein complex shelterin. TRF2 induces the formation of a special structure of telomeric DNA and counteracts activation of DNA damage-response ...
Nadya V. Ilicheva +3 more
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Euplotes crassushas genes encoding telomere-binding proteins and telomere-binding protein homologs [PDF]
Nucleic Acids Research, 1992 We have identified two 1.6 kb macronuclear DNA molecules from Euplotes crassus that hybridize to the alpha subunit of the Oxytricha telomere protein. We have shown that one of these molecules encodes the 51 kDa Euplotes telomere protein while the other appears to encode a homolog of the telomere protein.
Wenlan Wang +3 more
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