At Short Telomeres Tel1 Directs Early Replication and Phosphorylates Rif1 [PDF]
, 2014 Funding AS was supported by a Cancer Research UK PhD studentship and ORSAS. SK is supported by a Scottish Universities Life Sciences Alliance PhD studentship.
Donaldson, Anne D. +2 more
core +15 more sources
Plasmodium falciparum GBP2 Is a Telomere-Associated Protein That Binds to G-Quadruplex DNA and RNA
Frontiers in Cellular and Infection Microbiology, 2022 In the early-diverging protozoan parasite Plasmodium, few telomere-binding proteins have been identified and several are unique. Plasmodium telomeres, like those of most eukaryotes, contain guanine-rich repeats that can form G-quadruplex structures.
James Edwards-Smallbone +5 more
doaj +1 more source
Non-canonical roles of canonical telomere binding proteins in cancers [PDF]
Cellular and Molecular Life Sciences, 2021 AbstractReactivation of telomerase is a major hallmark observed in 90% of all cancers. Yet paradoxically, enhanced telomerase activity does not correlate with telomere length and cancers often possess short telomeres; suggestive of supplementary non-canonical roles that telomerase might play in the development of cancer.
Semih Can Akincilar +4 more
openaire +2 more sources
TZAP overexpression induces telomere dysfunction and ALT-like activity in ATRX/DAXX-deficient cells
iScience, 2023 Summary: The appropriate regulation of telomere length homeostasis is crucial for the maintenance of genome integrity. The telomere-binding protein TZAP has been suggested to regulate telomere length by promoting t-circle and c-circle excisions through ...
Sara Priego Moreno +7 more
doaj +1 more source
TRF2 controls telomeric nucleosome organization in a cell cycle phase-dependent manner [PDF]
, 2012 Mammalian telomeres stabilize chromosome ends as a result of their assembly into a peculiar form of chromatin comprising a complex of non-histone proteins named shelterin.
Bauwens, Serge +10 more
core +12 more sources
Sir4 Deficiency Reverses Cell Senescence by Sub-Telomere Recombination
Cells, 2021 Telomere shortening results in cellular senescence and the regulatory mechanisms remain unclear. Here, we report that the sub-telomere regions facilitate telomere lengthening by homologous recombination, thereby attenuating senescence in yeast ...
Jun Liu +4 more
doaj +1 more source
The TERB1 MYB domain suppresses telomere erosion in meiotic prophase I
Cell Reports, 2022 Summary: The meiosis-specific telomere-binding protein TERB1 anchors telomeres to the nuclear envelope and drives chromosome movements for the pairing of homologous chromosomes.
Kexin Zhang +6 more
doaj +1 more source
TRF1 and TRF2 binding to telomeres is modulated by nucleosomal organization [PDF]
, 2015 The ends of eukaryotic chromosomes need to be protected from the activation of a DNA damage response that leads the cell to replicative senescence or apoptosis.
Alicata, Claudia +8 more
core +3 more sources
The Ku subunit of telomerase binds Sir4 to recruit telomerase to lengthen telomeres in S. cerevisiae
eLife, 2015 In Saccharomyces cerevisiae and in humans, the telomerase RNA subunit is bound by Ku, a ring-shaped protein heterodimer best known for its function in DNA repair. Ku binding to yeast telomerase RNA promotes telomere lengthening and telomerase recruitment
Evan P Hass, David C Zappulla
doaj +1 more source
Emerging roles of telomeric chromatin alterations in cancer [PDF]
, 2019 Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin structure based on the interplay between the ...
Biroccio, Annamaria +2 more
core +1 more source