Structurally distinct telomere-binding proteins in Ustilago maydis execute non-overlapping functions in telomere replication, recombination, and protection [PDF]
Communications Biology, 2020 Yu et al. provide evidence that Ustilago maydis employs two structurally distinct telomere-binding proteins to perform complementary functions in telomere maintenance in this organism.
Eun Young Yu +6 more
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Duplex Telomere-Binding Proteins in Fungi With Canonical Telomere Repeats: New Lessons in the Rapid Evolution of Telomere Proteins [PDF]
Frontiers in Genetics, 2021 The telomere protein assemblies in different fungal lineages manifest quite profound structural and functional divergence, implying a high degree of flexibility and adaptability.
Neal F. Lue, Neal F. Lue
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Using centromere mediated genome elimination to elucidate the functional redundancy of candidate telomere binding proteins in Arabidopsis thaliana. [PDF]
Frontiers in Genetics, 2016 Proteins that bind to telomeric DNA form the key structural and functional constituents of telomeres. While telomere binding proteins have been described in the majority of organisms, their identity in plants remains unknown.
Karel eRiha, Nick eFulcher
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Non-canonical roles of canonical telomere binding proteins in cancers. [PDF]
Cell Mol Life Sci, 2021 AbstractReactivation of telomerase is a major hallmark observed in 90% of all cancers. Yet paradoxically, enhanced telomerase activity does not correlate with telomere length and cancers often possess short telomeres; suggestive of supplementary non-canonical roles that telomerase might play in the development of cancer.
Akincilar SC +4 more
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Gametes deficient for Pot1 telomere binding proteins alter levels of telomeric foci for multiple generations [PDF]
Communications Biology, 2021 Lister-Shimauchi et al. find that gametes from mutants that lack the genes encoding telomere binding proteins POT-1 or POT-2 affect the levels of POT1 telomere foci in progeny, in opposite ways, for multiple generations and that gametes deficient in ...
Evan H. Lister-Shimauchi +3 more
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Tay1 Protein, a Novel Telomere Binding Factor from Yarrowia lipolytica [PDF]
Journal of Biological Chemistry, 2020 Inspection of the complete genome of the yeast Yarrowia lipolytica for the presence of genes encoding homologues of known telomere-binding proteins surprisingly revealed no counterparts of typical yeast Myb domain-containing telomeric factors including Rap1 or Taz1.
Ľubomír Tomáška +6 more
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Telomere DNA recognition in Saccharomycotina yeast: potential lessons for the co-evolution of ssDNA and dsDNA-binding proteins and their target sites [PDF]
Frontiers in Genetics, 2015 In principle, alterations in the telomere repeat sequence would be expected to disrupt the protective nucleoprotein complexes that confer stability to chromosome ends, and hence relatively rare events in evolution.
Neal F. Lue +2 more
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Telomere-binding proteins play roles in control of replication timing [PDF]
Cell Cycle, 2012 Comment on: Tazumi A, et al. Genes Dev 2012; 26:2050-62.
Atsutoshi Tazumi, Hisao Masukata
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The Telomere-Binding Protein Tbf1 Demarcates snoRNA Gene Promoters in Saccharomyces cerevisiae [PDF]
Molecular Cell, 2010 Small nucleolar RNAs (snoRNAs) play a key role in ribosomal RNA biogenesis, yet factors controlling their expression are unknown. We found that the majority of Saccharomyces snoRNA promoters display an aRCCCTaa sequence motif at the upstream border of a TATA-containing nucleosome-free region.
Milena Preti +9 more
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A single‐stranded telomere binding protein in the nematode Caenorhabditis elegans [PDF]
FEBS Letters, 2001 We identified and characterized a protein (STB‐1) from the nuclear extract of Caenorhabditis elegans that specifically binds single‐stranded telomere DNA sequences, but not the corresponding RNA sequences. STB‐1 binding activity is specific to the nematode telomere, but not to the human or plant telomere.
Soo Young Yi +5 more
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