HYPOTHESIS: PARALOG FORMATION FROM PROGENITOR PROTEINS AND PARALOG MUTAGENESIS SPUR THE RAPID EVOLUTION OF TELOMERE BINDING PROTEINS [PDF]
Frontiers in Genetics, 2016 Through elegant studies in fungal cells and complex organisms, we propose a unifying paradigm for the rapid evolution of telomere binding proteins (TBPs) that associate with either (or both) telomeric DNA and telomeric proteins.
Arthur J Lustig
doaj +4 more sources
Duplex Telomere-Binding Proteins in Fungi With Canonical Telomere Repeats: New Lessons in the Rapid Evolution of Telomere Proteins [PDF]
Frontiers in Genetics, 2021 The telomere protein assemblies in different fungal lineages manifest quite profound structural and functional divergence, implying a high degree of flexibility and adaptability.
Neal F. Lue, Neal F. Lue
doaj +2 more sources
Structurally distinct telomere-binding proteins in Ustilago maydis execute non-overlapping functions in telomere replication, recombination, and protection [PDF]
Communications Biology, 2020 Yu et al. provide evidence that Ustilago maydis employs two structurally distinct telomere-binding proteins to perform complementary functions in telomere maintenance in this organism.
Eun Young Yu +6 more
doaj +2 more sources
Non-canonical roles of canonical telomere binding proteins in cancers. [PDF]
Cell Mol Life Sci, 2021 AbstractReactivation of telomerase is a major hallmark observed in 90% of all cancers. Yet paradoxically, enhanced telomerase activity does not correlate with telomere length and cancers often possess short telomeres; suggestive of supplementary non-canonical roles that telomerase might play in the development of cancer.
Akincilar SC +4 more
europepmc +4 more sources
Gametes deficient for Pot1 telomere binding proteins alter levels of telomeric foci for multiple generations [PDF]
Communications Biology, 2021 Lister-Shimauchi et al. find that gametes from mutants that lack the genes encoding telomere binding proteins POT-1 or POT-2 affect the levels of POT1 telomere foci in progeny, in opposite ways, for multiple generations and that gametes deficient in ...
Evan H. Lister-Shimauchi +3 more
doaj +2 more sources
Using centromere mediated genome elimination to elucidate the functional redundancy of candidate telomere binding proteins in Arabidopsis thaliana. [PDF]
Frontiers in Genetics, 2016 Proteins that bind to telomeric DNA form the key structural and functional constituents of telomeres. While telomere binding proteins have been described in the majority of organisms, their identity in plants remains unknown.
Karel eRiha, Nick eFulcher
doaj +2 more sources
Plant, Soil and Environment, 2007 A simple method for identification and characterization of telomere-binding proteins is described in this article. After Sodium Dodecyl Sulphate-Polyacrylamide gel electrophoresis (SDS-PAGE), proteins are eluted, renatured and used for retardation ...
G. Rotková
doaj +3 more sources
The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1. [PDF]
PLoS ONE, 2010 Telomere integrity (including telomere length and capping) is critical in overall genomic stability. Telomere repeat binding factors and their associated proteins play vital roles in telomere length regulation and end protection.
Richard J Giannone +5 more
doaj +3 more sources
Frontiers in Genetics, 2015 In principle, alterations in the telomere repeat sequence would be expected to disrupt the protective nucleoprotein complexes that confer stability to chromosome ends, and hence relatively rare events in evolution.
Neal F. Lue +2 more
doaj +3 more sources
Defining the chromatin-associated protein landscapes on Trypanosoma brucei repetitive elements using synthetic TALE proteins [PDF]
eLifeKinetoplastids, such as Trypanosoma brucei, are eukaryotes that likely separated from the main lineage at an exceptionally early point in evolution. Consequently, many aspects of kinetoplastid biology differ significantly from other eukaryotic model ...
Roberta Carloni +7 more
doaj +2 more sources