Euplotes crassushas genes encoding telomere-binding proteins and telomere-binding protein homologs [PDF]
We have identified two 1.6 kb macronuclear DNA molecules from Euplotes crassus that hybridize to the alpha subunit of the Oxytricha telomere protein. We have shown that one of these molecules encodes the 51 kDa Euplotes telomere protein while the other appears to encode a homolog of the telomere protein.
Wenlan Wang +3 more
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HYPOTHESIS: PARALOG FORMATION FROM PROGENITOR PROTEINS AND PARALOG MUTAGENESIS SPUR THE RAPID EVOLUTION OF TELOMERE BINDING PROTEINS [PDF]
Through elegant studies in fungal cells and complex organisms, we propose a unifying paradigm for the rapid evolution of telomere binding proteins (TBPs) that associate with either (or both) telomeric DNA and telomeric proteins.
Arthur J Lustig
doaj +2 more sources
Defining the chromatin-associated protein landscapes on Trypanosoma brucei repetitive elements using synthetic TALE proteins [PDF]
Kinetoplastids, such as Trypanosoma brucei, are eukaryotes that likely separated from the main lineage at an exceptionally early point in evolution. Consequently, many aspects of kinetoplastid biology differ significantly from other eukaryotic model ...
Roberta Carloni +7 more
doaj +2 more sources
Molecular cloning of telomere-binding protein gens fromStylonchia mytilis [PDF]
A telomere-binding protein heterodimer of 56 kDa (alpha) and 41 kDa (beta) subunits binds specifically to Oxytricha nova telomeres. Genes encoding both subunits have been cloned previously. Here we report molecular cloning and sequence analysis of the homologous genes in Stylonychia mytilis.
Guowei Fang, Thomas R. Cech
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Chaperone Association with Telomere Binding Proteins
VCU Theses and ...
Amy Depcrynski
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Telomeric repeats facilitate CENP-A(Cnp1) incorporation via telomere binding proteins.
The histone H3 variant, CENP-A, is normally assembled upon canonical centromeric sequences, but there is no apparent obligate coupling of sequence and assembly, suggesting that centromere location can be epigenetically determined.
Araceli G Castillo +7 more
doaj +3 more sources
Inhibition of the DNA Damage Pathway by a Telomere-Binding Protein
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At Short Telomeres Tel1 Directs Early Replication and Phosphorylates Rif1 [PDF]
Funding AS was supported by a Cancer Research UK PhD studentship and ORSAS. SK is supported by a Scottish Universities Life Sciences Alliance PhD studentship.
Donaldson, Anne D. +2 more
core +15 more sources
Plasmodium falciparum GBP2 Is a Telomere-Associated Protein That Binds to G-Quadruplex DNA and RNA
In the early-diverging protozoan parasite Plasmodium, few telomere-binding proteins have been identified and several are unique. Plasmodium telomeres, like those of most eukaryotes, contain guanine-rich repeats that can form G-quadruplex structures.
James Edwards-Smallbone +5 more
doaj +1 more source
The Saccharomyces cerevisiae telomerase subunit Est3 binds telomeres in a cell cycle- and Est1-dependent manner and interacts directly with Est1 in vitro. [PDF]
Telomerase is a telomere dedicated reverse transcriptase that replicates the very ends of eukaryotic chromosomes. Saccharomyces cerevisiae telomerase consists of TLC1 (the RNA template), Est2 (the catalytic subunit), and two accessory proteins, Est1 and ...
Creighton T Tuzon +3 more
doaj +1 more source

