Results 31 to 40 of about 77,771 (318)

The TERB1 MYB domain suppresses telomere erosion in meiotic prophase I

Cell Reports, 2022
Summary: The meiosis-specific telomere-binding protein TERB1 anchors telomeres to the nuclear envelope and drives chromosome movements for the pairing of homologous chromosomes.
Kexin Zhang, Agata Tarczykowska, Deepesh Kumar Gupta, Devon F. Pendlebury, Cassandra Zuckerman, Jayakrishnan Nandakumar, Hiroki Shibuya   +6 more
doaj   +1 more source

Double-strand break repair and homologous recombination in Schizosaccharomyces pombe [PDF]

, 2006
In recent years our understanding of double strand break repair and homologous recombination in Schizosaccharomyces pombe has increased significantly, and the identification of novel pathways and genes with homologues in higher eukaryotes has increased ...
Ahmad, Ahmad, Ahn, Ahnesorg, Akamatsu, Assenmacher, Baumann, Boddy, Boddy, Bonatto, Bransteitter, Buck, Callebaut, Caspari, Catlett, Cervantes, Chahwan, Cheok, Connelly, Cooper, Doe, Doe, Doe, Doe, Dudasova, Farah, Farah, Ferreira, Ferreira, Fukushima, Gaillard, Goedecke, Goodwin, Grishchuk, Haber, Hartsuiker, Hefferin, Jang, Jung, Khasanov, Khasanov, Kibe, Kim, Kim, Krogh, Lambert, Laursen, Macris, Maftahi, Maftahi, Manolis, Marchetti, Martin, McGlynn, Moore, Morishita, Muris, Muris, Muris, Murray, Nakada, Nakamura, Oakley, Ono, Osman, Osman, Osman, Ostermann, Paques, Parker, Prudden, Sauvageau, Schmidt, Segurado, Shinohara, Smith, Steiner, Stewart, Sung, Suto, Szankasi, Szostak, Tarsounas, Tavassoli, Thacker, Tomita, Tomita, Tsutsui, Tsutsui, Ueno, van den Bosch, van den Bosch, Virgin, Virgin, Wang, Weterings, Whitby, Whitby, Wilson, Win, Win, You, Young   +102 more
core   +2 more sources

Telomere length-dependent transcription and epigenetic modifications in promoters remote from telomere ends.

PLoS Genetics, 2018
Telomere-binding proteins constituting the shelterin complex have been studied primarily for telomeric functions. However, mounting evidence shows non-telomeric binding and gene regulation by shelterin factors.
Ananda Kishore Mukherjee, Shalu Sharma, Shalu Sharma, Suman Sengupta, Dhurjhoti Saha, Pankaj Kumar, Tabish Hussain, Vivek Srivastava, Sumitabho Deb Roy, Jerry W Shay, Shantanu Chowdhury, Shantanu Chowdhury   +11 more
doaj   +1 more source

Interactions of HMGB Proteins with the Genome and the Impact on Disease

Biomolecules, 2021
High Mobility Group Box (HMGB) proteins are small architectural DNA binding proteins that regulate multiple genomic processes such as DNA damage repair, nucleosome sliding, telomere homeostasis, and transcription.
Calvin K. Voong, James A. Goodrich, Jennifer F. Kugel   +2 more
doaj   +1 more source

Is PCNA unloading the central function of the Elg1/ATAD5 replication factor C-like complex? [PDF]

, 2013
This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.Peer ...
Donaldson, Anne D, Kubota, Takashi, Myung, Jae-Kyung   +2 more
core   +1 more source

Identification of the functional domains of the telomere protein Rap1 in Schizosaccharomyces pombe. [PDF]

PLoS ONE, 2012
The telomere at the end of a linear chromosome plays crucial roles in genome stability. In the fission yeast Schizosaccharomyces pombe, the Rap1 protein, one of the central players at the telomeres, associates with multiple proteins to regulate various ...
Ikumi Fujita, Makiko Tanaka, Junko Kanoh
doaj   +1 more source

TRF2 controls telomeric nucleosome organization in a cell cycle phase-dependent manner [PDF]

, 2012
Mammalian telomeres stabilize chromosome ends as a result of their assembly into a peculiar form of chromatin comprising a complex of non-histone proteins named shelterin.
Bauwens, Serge, Cacchione, Stefano, Colasanti, Valentina, Galati, Alessandra, Gilson, Eric, Giraud-Panis, Marie-Josèphe, Magdinier, Frédérique, Pinte, Sébastien, Pusch, Miriam Caroline, Ricordy, Ruggero, Savino, Maria   +10 more
core   +9 more sources

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Short-term inhibition of TERT induces telomere length-independent cell cycle arrest and apoptotic response in EBV-immortalized and transformed B cells [PDF]

, 2016
open7siBesides its canonical role in stabilizing telomeres, telomerase reverse transcriptase (TERT) may promote tumorigenesis through extra-telomeric functions.
Celeghin, Andrea, De Rossi, Anita, Dolcetti, Riccardo, Freguja, Riccardo, Giunco, Silvia, Nalio, Silvia, Zangrossi, Manuela   +6 more
core   +1 more source

Toward a molecular understanding of yeast silent chromatin : roles for H4K16 acetylation and the Sir3 C-terminus [PDF]

, 2012
Discrete regions of the eukaryotic genome assume a heritable chromatin structure that is refractory to gene expression. In budding yeast, silent chromatin is characterized by the loading of the Silent Information Regulatory (Sir) proteins (Sir2, Sir3 and
Oppikofer, Mariano
core   +1 more source