Results 51 to 60 of about 47,830 (278)

The telomere binding proteins in yeast and their role in telomere maintenance [PDF]

, 2013
Telomeres are the end-structures of linear chromosome which are crucial for maintaining genome integrity. The telomeres prevent the DNA-repair machinery from recognizing the chromosome ends as double-strand breaks and from end-to-end fusions.
Gustafsson, Cecilia
core   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

ZBTB48 is both a vertebrate telomere‐binding protein and a transcriptional activator

The EMBO Reports, 2017
Telomeres constitute the ends of linear chromosomes and together with the shelterin complex form a structure essential for genome maintenance and stability. In addition to the constitutive binding of the shelterin complex, other direct, yet more transient interactions are mediated by the CST complex and HOT1/HMBOX1, while subtelomeric variant repeats ...
Arne Jahn, Grishma Rane, Maciej Paszkowski‐Rogacz, Sergi Sayols, Alina Bluhm, Chung‐Ting Han, Irena Draškovič, José Arturo Londoño‐Vallejo, Alan Prem Kumar, Frank Buchholz, Falk Butter, Dennis Kappei   +11 more
openaire   +4 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Telomere DNA length-dependent regulation of DNA replication timing at internal late replication origins

Scientific Reports, 2019
DNA replication is initiated at replication origins on chromosomes at their scheduled time during S phase of the cell cycle. Replication timing control is highly conserved among eukaryotes but the underlying mechanisms are not fully understood.
Yudai Hasegawa, Mayuko Yamamoto, Junki Miyamori, Junko Kanoh   +3 more
doaj   +1 more source

Identification of a Putative Mitochondrial Telomere-binding Protein of the Yeast Candida parapsilosis [PDF]

Journal of Biological Chemistry, 1997
Terminal segments (telomeres) of linear mitochondrial DNA (mtDNA) molecules of the yeast Candida parapsilosis consist of large sequence units repeated in tandem. The extreme ends of mtDNA terminate with a 5' single-stranded overhang of about 110 nucleotides.
L, Tomáska, J, Nosek, H, Fukuhara
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Tay1 Protein, a Novel Telomere Binding Factor from Yarrowia lipolytica [PDF]

Journal of Biological Chemistry, 2010
Inspection of the complete genome of the yeast Yarrowia lipolytica for the presence of genes encoding homologues of known telomere-binding proteins surprisingly revealed no counterparts of typical yeast Myb domain-containing telomeric factors including Rap1 or Taz1.
Juraj, Kramara, Smaranda, Willcox, Stanislava, Gunisova, Slavomir, Kinsky, Jozef, Nosek, Jack D, Griffith, Lubomir, Tomaska   +6 more
openaire   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

The role of telomere binding proteins in inherited telomere syndromes [PDF]

Telomere binding proteins play a role in telomere end protection as well as in the regulation of telomerase repeat addition. Mutations in genes encoding telomere binding proteins were recently identified in families with cancer predisposition; however ...
DeBoy, Emily
core   +2 more sources