Results 61 to 70 of about 47,830 (278)
Selaginella moellendoffii telomeres: conserved and unique features in an ancient land plant lineage
Frontiers in Plant Science, 2012 Telomeres, the essential terminal regions of linear eukaryotic chromosomes, consist of G-rich DNA repeats bound by a plethora of associated proteins. While the general pathways of telomere maintenance are evolutionarily conserved, individual telomere ...
Eugene V Shakirov, Dorothy E Shippen
doaj +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Isolation and characterization of telomere binding proteins from Cestrum elegans [PDF]
, 2016 Telomeres are nucleoprotein structures essential for chromosomal integrity and stability. Telomere binding proteins are classified into two groups based on the telomere structure (i) Double-strand TBP (ii) Single-strand TBP. So far very few potential TBP'
Nishita Matcha Balaguruvappa
core +1 more source
Mammalian telomere dynamics: healing, fragmentation shortening and stabilization [PDF]
, 1994 Telomeres are essential for stable chromosome maintenance. The simple G-rich sequence motif d(TTAGGG)n is all that is required in cis for telomere function in mammalian cells, as in other eukaryotes.
Greider, C. W.
core +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Molecular recognition in complexes of TRF proteins with telomeric DNA.
PLoS ONE, 2014 Telomeres are specialized nucleoprotein assemblies that protect the ends of linear chromosomes. In humans and many other species, telomeres consist of tandem TTAGGG repeats bound by a protein complex known as shelterin that remodels telomeric DNA into a ...
Miłosz Wieczór +4 more
doaj +1 more source
Advanced Science, EarlyView.PRC2.1(PCL2)‐coordinated H3K27me3‐enriched PNH establishes a spatial scaffold crucial for nucleolar integrity. As a crucial coordinator, PCL2 links PRC2.1 to chromatin organization and NPM1 assembly. This network‐based model reveals how chromatin modifications and nucleolar components cooperatively maintain nucleolar architecture, revealing novel ...
Lina Zhu +12 more
wiley +1 more source
Nature Communications, 2023 Double-strand breaks (DSBs) due to genotoxic stress represent potential threats to genome stability. Dysfunctional telomeres are recognized as DSBs and are repaired by distinct DNA repair mechanisms.
Rekha Rai +9 more
doaj +1 more source
Telomeres and telomere binding proteins in Arabidopsis thaliana [PDF]
, 2004 Telomeres are important protein-DNA structures at the ends of linear eukaryotic chromosomes that are necessary to prevent chromosome fusions and exonuclease attack.
Shakirov, Yevgeniy Vitalievich
core
Advanced Science, EarlyView.Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang +6 more
wiley +1 more source