Results 41 to 50 of about 47,830 (278)
Mapping of interaction domains of putative telomere-binding proteins AtTRB1 and AtPOT1b from Arabidopsis thaliana [PDF]
, 2008 We previously searched for interactions between plant telomere-binding proteins and found that AtTRB1, from the single-myb-histone (Smh) family, interacts with the Arabidopsis POT1-like-protein, AtPOT1b, involved in telomere capping.
Paleček, Jan +7 more
core +1 more source
The Ku subunit of telomerase binds Sir4 to recruit telomerase to lengthen telomeres in S. cerevisiae
eLife, 2015 In Saccharomyces cerevisiae and in humans, the telomerase RNA subunit is bound by Ku, a ring-shaped protein heterodimer best known for its function in DNA repair. Ku binding to yeast telomerase RNA promotes telomere lengthening and telomerase recruitment
Evan P Hass, David C Zappulla
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Poly(ADP-ribose) polymerase 1 (PARP1) is established as a key regulator of the cellular DNA damage response and apoptosis. In addition, PARP1 participates in the global regulation of DNA repair, transcription, telomere maintenance, and inflammation ...
Nikita V. Savelyev +10 more
doaj +1 more source
A single‐stranded telomere binding protein in the nematode Caenorhabditis elegans [PDF]
FEBS Letters, 2001 We identified and characterized a protein (STB‐1) from the nuclear extract of Caenorhabditis elegans that specifically binds single‐stranded telomere DNA sequences, but not the corresponding RNA sequences. STB‐1 binding activity is specific to the nematode telomere, but not to the human or plant telomere.
Yi, Soo Young +5 more
openaire +2 more sources
Characterization of the telomere binding protein ZNF524
, 2022 127, v Seiten ; Illustrationen ...
openaire +3 more sources
PLoS Genetics, 2020 DNA double-strand breaks (DSBs) are toxic forms of DNA damage that must be repaired to maintain genome integrity. Telomerase can act upon a DSB to create a de novo telomere, a process that interferes with normal repair and creates terminal deletions.
Esther A Epum +3 more
doaj +1 more source
Telomere maintenance and the DNA damage response: a paradoxical alliance
Frontiers in Cell and Developmental BiologyTelomeres are the protective caps at the ends of linear chromosomes of eukaryotic organisms. Telomere binding proteins, including the six components of the complex known as shelterin, mediate the protective function of telomeres.
Ashley Harman, Tracy M. Bryan
doaj +1 more source
The Telomere Binding Protein TRF2 Induces Chromatin Compaction
PLoS ONE, 2011 Mammalian telomeres are specialized chromatin structures that require the telomere binding protein, TRF2, for maintaining chromosome stability. In addition to its ability to modulate DNA repair activities, TRF2 also has direct effects on DNA structure and topology.
Asmaa M Baker +6 more
openaire +5 more sources
G-Quadruplex-Binding Proteins: Promising Targets for Drug Design
Biomolecules, 2022 G-quadruplexes (G4s) are non-canonical secondary nucleic acid structures. Sequences with the potential to form G4s are abundant in regulatory regions of the genome including telomeres, promoters and 5′ non-coding regions, indicating they fulfill ...
Huiling Shu +4 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source