Results 21 to 30 of about 47,830 (278)

Persistent telomere cohesion protects aged cells from premature senescence

Nature Communications, 2020
Telomere function is regulated by the telomere repeat binding proteins TRF1 and TRF2. Here the authors show that decreased levels of TRF1 proteins at shortened telomeres in aged human cells results in persistent telomere cohesion, protecting from ...
Kameron Azarm, Amit Bhardwaj, Eugenie Kim, Susan Smith   +3 more
doaj   +1 more source

Ustilago maydis telomere protein Pot1 harbors an extra N-terminal OB fold and regulates homology-directed DNA repair factors in a dichotomous and context-dependent manner.

PLoS Genetics, 2022
The telomere G-strand binding protein Pot1 plays multifaceted roles in telomere maintenance and protection. We examined the structure and activities of Pot1 in Ustilago maydis, a fungal model that recapitulates key features of mammalian telomere ...
Syed Zahid, Sarah Aloe, Jeanette H Sutherland, William K Holloman, Neal F Lue   +4 more
doaj   +1 more source

Regulation of Antigenic Variation by Trypanosoma brucei Telomere Proteins Depends on Their Unique DNA Binding Activities

Pathogens, 2021
Trypanosoma brucei causes human African trypanosomiasis and regularly switches its major surface antigen, Variant Surface Glycoprotein (VSG), to evade the host immune response.
Bibo Li, Yanxiang Zhao
doaj   +1 more source

The TERB1 MYB domain suppresses telomere erosion in meiotic prophase I

Cell Reports, 2022
Summary: The meiosis-specific telomere-binding protein TERB1 anchors telomeres to the nuclear envelope and drives chromosome movements for the pairing of homologous chromosomes.
Kexin Zhang, Agata Tarczykowska, Deepesh Kumar Gupta, Devon F. Pendlebury, Cassandra Zuckerman, Jayakrishnan Nandakumar, Hiroki Shibuya   +6 more
doaj   +1 more source

Telomere length-dependent transcription and epigenetic modifications in promoters remote from telomere ends.

PLoS Genetics, 2018
Telomere-binding proteins constituting the shelterin complex have been studied primarily for telomeric functions. However, mounting evidence shows non-telomeric binding and gene regulation by shelterin factors.
Ananda Kishore Mukherjee, Shalu Sharma, Shalu Sharma, Suman Sengupta, Dhurjhoti Saha, Pankaj Kumar, Tabish Hussain, Vivek Srivastava, Sumitabho Deb Roy, Jerry W Shay, Shantanu Chowdhury, Shantanu Chowdhury   +11 more
doaj   +1 more source

Structure of DNA Binding Domain of Plant Telomere Binding Proteins Represents Unique Features of Telomere Binding Protein Family [PDF]

Biophysical Journal, 2010
Telomeres, the ends of linear eukaryotic chromosomes, are composed of short repeats of G-rich sequences and play essential roles in genome stability with various telomere binding proteins. To characterize the binding mode of plant telomere DNA and telomere binding protein, we determined the structures of DNA binding domain and telomere complex of ...
Lee, Weontae, Ko, Sunggeon, Cho, Hyun-Soo, Cheong, Chaejoon   +3 more
openaire   +1 more source

Epiphenomenon of telomere lengths : lessons from ulcerative colitis [PDF]

, 2012
We read with great interest the article by Jones et al detailing TERC polymorphisms, longer telomeres and increased risk of colorectal cancer (CRC).1 Indeed, it is accepted that shorter telomere lengths (measured from peripheral leucocytes) have been ...
Arasaradnam, Ramesh P., Nwokolo, Chuka U.   +1 more
core   +1 more source

Identification of the functional domains of the telomere protein Rap1 in Schizosaccharomyces pombe. [PDF]

PLoS ONE, 2012
The telomere at the end of a linear chromosome plays crucial roles in genome stability. In the fission yeast Schizosaccharomyces pombe, the Rap1 protein, one of the central players at the telomeres, associates with multiple proteins to regulate various ...
Ikumi Fujita, Makiko Tanaka, Junko Kanoh
doaj   +1 more source

Interactions of HMGB Proteins with the Genome and the Impact on Disease

Biomolecules, 2021
High Mobility Group Box (HMGB) proteins are small architectural DNA binding proteins that regulate multiple genomic processes such as DNA damage repair, nucleosome sliding, telomere homeostasis, and transcription.
Calvin K. Voong, James A. Goodrich, Jennifer F. Kugel   +2 more
doaj   +1 more source

The Protein hSnm1B Is Stabilized When Bound to the Telomere-binding Protein TRF2 [PDF]

Journal of Biological Chemistry, 2008
hSnm1B is member of the SNM family of exonucleases involved in DNA processing and is known to be localized to telomeres via binding to the telomere-binding protein TRF2. Here we demonstrate that the C terminus of hSnm1B facilitates the concentration of hSnm1B on telomeres by promoting ubiquitin-mediated degradation of hSnm1B that is not localized to ...
Brian D, Freibaum, Christopher M, Counter   +1 more
openaire   +2 more sources