Results 41 to 50 of about 85,495 (318)
Cell Reports, 2018 Summary: The Saccharomyces cerevisiae telomere-binding protein Rif1 plays an evolutionarily conserved role in control of DNA replication timing by promoting PP1-dependent dephosphorylation of replication initiation factors.
Lukas Hafner +10 more
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The telomerase essential N-terminal domain promotes DNA synthesis by stabilizing short RNA-DNA hybrids. [PDF]
, 2015 Telomerase is an enzyme that adds repetitive DNA sequences to the ends of chromosomes and consists of two main subunits: the telomerase reverse transcriptase (TERT) protein and an associated telomerase RNA (TER). The telomerase essential N-terminal (TEN)
Akiyama, Benjamin M +2 more
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Characterization of a Telomere-Binding Protein from Physarum polycephalum [PDF]
Molecular and Cellular Biology, 1991 We have partially purified a nuclear protein (PPT) from Physarum polycephalum that binds to the extrachromosomal ribosomal DNA telomeres of this acellular slime mold. Binding is specific for the (T2AG3)n telomere repeats, as evidenced by nitrocellulose filter binding assays, by gel mobility shift assays with both DNA fragments and double-stranded ...
J S, Coren, E M, Epstein, V M, Vogt
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Ku80 facilitates chromatin binding of the telomere binding protein, TRF2 [PDF]
Cell Cycle, 2010 The Ku70/80 heterodimer is central to non-homologous end joining repair of DNA double-strand breaks and the Ku80 gene appears to be essential for human but not rodent cell survival. The Ku70/80 heterodimer is located at telomeres but its precise function in telomere maintenance is not known.
Lauren S, Fink +3 more
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Telomere Function and the G-Quadruplex Formation are Regulated by hnRNP U
Cells, 2019 We examine the role of the heterogenous ribonucleoprotein U (hnRNP U) as a G-quadruplex binding protein in human cell lines. Hypothesizing that hnRNP U is associated with telomeres, we investigate what other telomere-related functions it may have ...
Hiroto Izumi, Keiko Funa
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The pif1 helicase, a negative regulator of telomerase, acts preferentially at long telomeres. [PDF]
PLoS Genetics, 2015 Telomerase, the enzyme that maintains telomeres, preferentially lengthens short telomeres. The S. cerevisiae Pif1 DNA helicase inhibits both telomerase-mediated telomere lengthening and de novo telomere addition at double strand breaks (DSB).
Jane A Phillips +3 more
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Double-strand break repair and homologous recombination in Schizosaccharomyces pombe [PDF]
, 2006 In recent years our understanding of double strand break repair and homologous recombination in Schizosaccharomyces pombe has increased significantly, and the identification of novel pathways and genes with homologues in higher eukaryotes has increased ...
Ahmad +102 more
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Toward a molecular understanding of yeast silent chromatin : roles for H4K16 acetylation and the Sir3 C-terminus [PDF]
, 2012 Discrete regions of the eukaryotic genome assume a heritable chromatin structure that is refractory to gene expression. In budding yeast, silent chromatin is characterized by the loading of the Silent Information Regulatory (Sir) proteins (Sir2, Sir3 and
Oppikofer, Mariano
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PLoS Genetics, 2020 DNA double-strand breaks (DSBs) are toxic forms of DNA damage that must be repaired to maintain genome integrity. Telomerase can act upon a DSB to create a de novo telomere, a process that interferes with normal repair and creates terminal deletions.
Esther A Epum +3 more
doaj +1 more source
Pol α-primase dependent nuclear localization of the mammalian CST complex
Communications Biology, 2021 Kelich, Papaioannou and Skordalakes investigate the intracellular localization dynamics of the mammalian CST, a protein complex critical for telomere maintenance and homeostasis.
Joseph M. Kelich +2 more
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