Results 51 to 60 of about 85,495 (318)

Smc5/6: a link between DNA repair and unidirectional replication? [PDF]

, 2008
Of the three structural maintenance of chromosome (SMC) complexes, two directly regulate chromosome dynamics. The third, Smc5/6, functions mainly in homologous recombination and in completing DNA replication.
A Losada, Antony M. Carr, AR Lehmann, B Hu, D Branzei, D Ivanov, DM Sheedy, E Ampatzidou, E Unal, E Unal, EA Andrews, ES Chen, F Onoda, G De Piccoli, GJ Cost, H Morikawa, HB Lindroos, HM Verkade, I Miyabe, J Palecek, J Rouse, J Sergeant, J Torres-Rosell, J Torres-Rosell, JK Chin, Johanne M. Murray, KL Borden, KM Lee, L Strom, L Strom, MI Fousteri, MN Boddy, N Aono, PR Potts, PR Potts, PR Potts, S Pebernard, S Pebernard, SH Harvey, T de Lange, T Kobayashi, T Mengiste, T Morishita, TM Roberts, WH McDonald, WM Thorburn, X Zhao   +46 more
core   +1 more source

Association between micronutrients and maternal leukocyte telomere length in early pregnancy in Rwanda

BMC Pregnancy and Childbirth, 2020
Background Exposure to environmental stressors can lead to shorter leukocyte telomere length and increase the risk of chronic diseases. Preservation of leukocyte telomere length by reducing oxidative stress exposure and reinforcing immunity may be a ...
Etienne Nsereko, Aline Uwase, Claude Mambo Muvunyi, Stephen Rulisa, David Ntirushwa, Patricia Moreland, Elizabeth J. Corwin, Nicole Santos, Jue Lin, Jyu-Lin Chen, Manasse Nzayirambaho, Janet M. Wojcicki   +11 more
doaj   +1 more source

Cancer-associated TERT promoter mutations abrogate telomerase silencing. [PDF]

, 2015
Mutations in the human telomerase reverse transcriptase (TERT) promoter are the most frequent non-coding mutations in cancer, but their molecular mechanism in tumorigenesis has not been established.
Boyle, John, Chiba, Kunitoshi, Hockemeyer, Dirk, Johnson, Joshua, Vogan, Jacob, Wagner, Tina   +5 more
core   +1 more source

Plant telomere-binding proteins

Biologia plantarum, 2006
Telomere-binding proteins have recently been recognised not only as necessary building blocks of telomere structure, but namely as components which are of central importance to telomere metabolism being involved in regulation of telomere length as well as in protective (capping) function of telomeres.
openaire   +1 more source

Identification of the functional domains of the telomere protein Rap1 in Schizosaccharomyces pombe. [PDF]

PLoS ONE, 2012
The telomere at the end of a linear chromosome plays crucial roles in genome stability. In the fission yeast Schizosaccharomyces pombe, the Rap1 protein, one of the central players at the telomeres, associates with multiple proteins to regulate various ...
Ikumi Fujita, Makiko Tanaka, Junko Kanoh
doaj   +1 more source

Extra-telomeric functions of telomerase in the pathogenesis of Epstein-Barr virus-driven B-cell malignancies and potential therapeutic implications [PDF]

, 2018
The Epstein-Barr virus (EBV) is a ubiquitous human \u3b3-herpesvirus causally linked to a broad spectrum of both lymphoid and epithelial malignancies.
Celeghin, Andrea, De Rossi, Anita, Giunco, Silvia, Petrara, Maria Raffaella, Zangrossi, Manuela   +4 more
core   +1 more source

Nontelomeric Role for Rap1 in Regulating Metabolism and Protecting against Obesity

Cell Reports, 2013
The mammalian telomere-binding protein Rap1 was recently found to have additional nontelomeric functions, acting as a transcriptional cofactor and a regulator of the NF-κB pathway. Here, we assess the effect of disrupting mouse Rap1 in vivo and report on
Frank Yeung, Cristina M. Ramírez, Pedro A. Mateos-Gomez, Alexandra Pinzaru, Giovanni Ceccarini, Shaheen Kabir, Carlos Fernández-Hernando, Agnel Sfeir   +7 more
doaj   +1 more source

PARP1 Regulates the Biogenesis and Activity of Telomerase Complex Through Modification of H/ACA-Proteins

Frontiers in Cell and Developmental Biology, 2021
Poly(ADP-ribose) polymerase 1 (PARP1) is established as a key regulator of the cellular DNA damage response and apoptosis. In addition, PARP1 participates in the global regulation of DNA repair, transcription, telomere maintenance, and inflammation ...
Nikita V. Savelyev, Nikita V. Savelyev, Nikita M. Shepelev, Olga I. Lavrik, Olga I. Lavrik, Maria P. Rubtsova, Maria P. Rubtsova, Olga A. Dontsova, Olga A. Dontsova, Olga A. Dontsova, Olga A. Dontsova   +10 more
doaj   +1 more source

Csm4-dependent telomere movement on nuclear envelope promotes meiotic recombination. [PDF]

PLoS Genetics, 2008
During meiotic prophase, chromosomes display rapid movement, and their telomeres attach to the nuclear envelope and cluster to form a "chromosomal bouquet." Little is known about the roles of the chromosome movement and telomere clustering in this phase.
Hiromichi Kosaka, Miki Shinohara, Akira Shinohara   +2 more
doaj   +1 more source

Coronectomy of deeply impacted lower third molar : incidence of outcomes and complications after one year follow-up [PDF]

, 2015
Objectives: The purpose of present study was to assess the surgical management of impacted third molar with proximity to the inferior alveolar nerve and complications associated with coronectomy in a series of patients undergoing third molar surgery ...
Ajbage, Jimoh Olubanwo, Heijsters, Guido, Politis, Constantinus, Salem, Ahmed Sobhy, Schepers, Serge, Van Slycke, Sarah, Vrielinck, Luc   +6 more
core   +3 more sources