Results 21 to 30 of about 116,824 (219)

The human telomeric proteome during telomere replication [PDF]

Nucleic Acids Research, 2020
Abstract Telomere shortening can cause detrimental diseases and contribute to aging. It occurs due to the end replication problem in cells lacking telomerase. Furthermore, recent studies revealed that telomere shortening can be attributed to difficulties of the semi-conservative DNA replication machinery to replicate the bulk of ...
Chih-Yi Gabriela Lin, Anna Christina Näger, Thomas Lunardi, Aleksandra Vančevska, Gérald Lossaint, Joachim Lingner   +5 more
openaire   +3 more sources

Circulating leukocyte telomere length is highly heritable among families of Arab descent [PDF]

, 2012
Background Telomere length, an indicator of ageing and longevity, has been correlated with several biomarkers of cardiometabolic disease in both Arab children and adults.
Alokail Majed S, Shaun B Sabico, Assim A Alfadda, Sabico, Shaun, George P Chrousos, Omar S Al-Attas, Alokail, Majed S., Al-Attas, Omar S., Philip McTernan, Al-Daghri, Nasser M., Greg C Gibson, Al-Attas Omar S, Majed S Alokail, Gibson, Greg, Alkharfy Khalid M, Alfadda, Assim, Chrousos, George P., Gibson Greg C, Chrousos George P, McTernan Philip, Nasser M Al-Daghri, Sabico Shaun B, Al-Daghri Nasser M, Alfadda Assim A, Alkharfy, Khalid M., McTernan, P. G. (Philip G.), Khalid M Alkharfy   +26 more
core   +1 more source

Measuring telomere length and telomere dynamics in evolutionary biology and ecology [PDF]

, 2014
Telomeres play a fundamental role in the protection of chromosomal DNA and in the regulation of cellular senescence. Recent work in human epidemiology and evolutionary ecology suggests adult telomere length (TL) may reflect past physiological stress and ...
Barrett, Emma, Boner, Winnie, Hartmann, Nils, Nussey, Daniel H., Turbill, Christopher (R16915), Verhulst, Simon; id_orcid, Baird, Duncan Martin, Turbill, Chris, Leder, Erica, Monaghan, Pat, Olsson, Mats, Zahn, Sandrine, Horn, Thorsten, Verhulst, Simon, Haussmann, Mark, Gemmell, Neil, Fairlie, Jennifer, Baird, Duncan   +17 more
core   +1 more source

Sir4 Deficiency Reverses Cell Senescence by Sub-Telomere Recombination

Cells, 2021
Telomere shortening results in cellular senescence and the regulatory mechanisms remain unclear. Here, we report that the sub-telomere regions facilitate telomere lengthening by homologous recombination, thereby attenuating senescence in yeast ...
Jun Liu, Xiaojing Hong, Lihui Wang, Chao-Ya Liang, Jun-Ping Liu   +4 more
doaj   +1 more source

Telomeres and telomerase [PDF]

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2004
Telomeres are the protective DNA–protein complexes found at the ends of eukaryotic chromosomes. Telomeric DNA consists of tandem repeats of a simple, often G–rich, sequence specified by the action of telomerase, and complete replication of telomeric DNA requires telomerase.
Simon R W L, Chan, Elizabeth H, Blackburn   +1 more
openaire   +2 more sources

Telomere Length and Physical Performance at Older Ages: An Individual Participant Meta-Analysis [PDF]

, 2013
Background Telomeres are involved in cellular ageing and shorten with increasing age. If telomere length is a valuable biomarker of ageing, then telomere shortening should be associated with worse physical performance, an ageing trait, but evidence ...
Hardy, R, John M. Starr (107707), Cooper, R, Rachel Cooper, von Zglinicki, Thomas, Halcyon study team, Parsons, Sam, Martin-Ruiz, C., Lennox, Alison, Kuh, D., Murray, Emily, Yoav Ben-Shlomo, Aihie Sayer, Avan, Shiels, Paul G, Thomas von Zglinicki, Martin, Richard, Carmen Martin-Ruiz (126509), Cooper Cyrus, Hardy, R., Hardy, Rachel, Deary, Ian, Gardner, M.P., Team, HS, Cooper, Cryus, von Zglinicki, T., Sayer Avan Aihie, John M Starr, Shiels, P.G., Ben-Shlomo, Yoav, Ian J. Deary (107724), Harris, Sarah E, Gardner, Michael, Sayer, AA, Day, Ian, team, Halcyon study, Sarah E Harris, Ian J Deary, Gallacher, J., Aucott, Paula, Harris, Sarah, Martin-Ruiz, C, Paul G Shiels, Gardner, MP, Southall, Humphrey, Kuh, Diana, Rebecca Hardy (188906), von Zglinicki Thomas, Deary, Ian J, Michael P. Gardner (381155), Goodwin, James, Michael P Gardner, Thomas von Zglinicki (73277), Yoav Ben-Shlomo (95286), Alfred, Tamuno, Cooper, C., Diana Kuh, Gallacher John, Ben-Shlomo, Y., Starr John M., Deary Ian J., Elliott, Jane, Cooper, C, Starr, J.M., Shiels, Paul G., Shiels, Paul, Rachel Cooper (188902), Shiels, PG, Harris Sarah E., Kuh Diana, Gallacher, John, Gardner, Michael P., Craig, Leone, Richards, Marcus, Starr, John M., John Gallacher, Mulla, Zeinab, Starr, John M, Gale, Catherine, Ben-Shlomo, Y, Carmen Martin-Ruiz, Demakakos, Panos, Gardner, Mike P, Cyrus Cooper (141250), Cooper, R., John Gallacher (196569), Sayer, A.A., Cyrus Cooper, Harris, S.E., Hardy, Rebecca, McNeill, Geraldine, Starr, JM, Harris, SE, ?, ?, Avan Aihie Sayer, Cooper, Rachel, Deary, IJ, Cooper Rachel, Gardner, Michael P, Avan Aihie Sayer (188916), Rebecca Hardy, Whalley, Lawrence, Shiels Paul G., Martin-Ruiz Carmen, Hardy Rebecca, Martin-Ruiz, Carmen, Deary, Ian J., Tilling, Kate, Harris, Sarah E., Gardner Michael P., Cooper, Cyrus, Power, Chris, Paul G. Shiels (125083), Sayer, Avan Aihie, Gallacher, J, Mishra, Gita, von Zglinicki, T, Kuh, D, von, Zglinicki T, Steptoe, Andrew, Ben-Shlomo Yoav, Sarah E. Harris (107676), Diana Kuh (188923), Starr, John, Deary, I.J.   +123 more
core   +1 more source

The telomere syndromes [PDF]

Nature Reviews Genetics, 2012
There has been mounting evidence of a causal role for telomere dysfunction in a number of degenerative disorders. Their manifestations encompass common disease states such as idiopathic pulmonary fibrosis and bone marrow failure. Although these disorders seem to be clinically diverse, collectively they comprise a single syndrome spectrum defined by the
Armanios, Mary, Blackburn, Elizabeth H
openaire   +4 more sources

Telomeres and Their Neighbors

Genes, 2022
Telomeres are essential structures formed from satellite DNA repeats at the ends of chromosomes in most eukaryotes. Satellite DNA repeat sequences are useful markers for karyotyping, but have a more enigmatic role in the eukaryotic cell. Much work has been done to investigate the structure and arrangement of repetitive DNA elements in classical models ...
Leon P. Jenner, Vratislav Peska, Jana Fulnečková, Eva Sýkorová   +3 more
openaire   +2 more sources

The JIL-1 kinase affects telomere expression in the different telomere domains of Drosophila. [PDF]

PLoS ONE, 2013
In Drosophila, the non-LTR retrotransposons HeT-A, TART and TAHRE build a head-to-tail array of repetitions that constitute the telomere domain by targeted transposition at the end of the chromosome whenever needed. As a consequence, Drosophila telomeres
Rute Silva-Sousa, Elena Casacuberta
doaj   +1 more source

Accelerated telomere attrition is associated with relative household income, diet and inflammation in the pSoBid cohort [PDF]

, 2011
BACKGROUND: It has previously been hypothesized that lower socio-economic status can accelerate biological ageing, and predispose to early onset of disease.
Batty, G.D., McGlynn, LM, Jennifer S McLean, Johnson, P.C.D., MacIntyre, Alan, Ford Ian, Yoga Nathan (12346540), Tannahill, Carol, Carol Tannahill, McLean, JS, McGinty, A., Liane M. McGlynn (12597766), Millar, K, MacIntyre, A., McConnachie, A, Burns Harry, MacIntyre Alan, Cavanagh Jonathan, Cavanagh, Jonathan, Tannahill Carol, Shiels, P.G., Chris J. Packard, Jonathan Cavanagh (125077), Deans, K.A., Kevin A. Deans, McGinty Agnes, Chris J. Packard (12592780), Tannahill, C., Keith Millar, Jennifer S. Mclean, Ford, I, Sattar, N., G David Batty, Kevin A. Deans (12592774), McGlynn Liane M., Burns, Harry, Ford, I., Paul G Shiels, Sattar Naveed, Naveed Sattar (8785), Batty, David G., Harry Burns (125075), McConnachie Alex, Liane M. Mcglynn, Packard, C.J., Burns, H, McGinty, Agnes, Miller, Keith, Cavanagh, J., Johnson, Paul C.D., McLean, Jennifer S., Sattar, Naveed, Packard, CJ, Batty G. David, Batty, GD, Johnson, PCD, Shiels, Paul G., Shiels, PG, Paul C. D. Johnson, G. David Batty, Paul C D Johnson, McLean Jennifer S., Sattar, N, Chris J Packard, Burns, H., Millar, K., McGinty, A, Ian Ford, Alex McConnachie (104022), Agnes McGinty, Deans Kevin A., Velupillai, YN, Jennifer S. McLean (12592768), McConnachie, A., Ian Ford (30666), MacIntyre, A, Millar Keith, Velupillai Yoga N., Paul C.D. Johnson (12597769), McConnachie, Alex, Deans, KA, McGlynn, L.M., Naveed Sattar, Paul G. Shiels (12592783), Ford, Ian, Liane M McGlynn, Shiels Paul G., Agnes McGinty (212297), Keith Miller (2363098), Kevin A Deans, Paul G. Shiels, Jonathan Cavanagh, Carol Tannahill (212305), Chris J, McGlynn, Liane M., Deans, Kevin A., Alex McConnachie, David G. Batty (12592771), Cavanagh, J, Velupillai, Y.N., Alan MacIntyre, Johnson Paul C. D., Nathan, Yoga, Alan MacIntyre (212284), McLean, J.S., Tannahill, C, Yoga N Velupillai, Harry Burns, Packard Chris J., Packard, Chris J., Yoga N. Velupillai   +110 more
core   +1 more source