Results 21 to 30 of about 241,247 (399)

Retrotransposons and Telomeres

Biochemistry (Moscow), 2023
Abstract Transposable elements (TEs) comprise a significant part of eukaryotic genomes being a major source of genome instability and mutagenesis. Cellular defense systems suppress the TE expansion at all stages of their life cycle. Piwi proteins and Piwi-interacting RNAs (piRNAs) are key elements of the anti-transposon
Alla I, Kalmykova, Olesya A, Sokolova
openaire   +2 more sources

Distinct ‘safe zones’ at the nuclear envelope ensure robust replication of heterochromatic chromosome regions

eLife, 2018
Chromosome replication and transcription occur within a complex nuclear milieu whose functional subdomains are beginning to be mapped out. Here we delineate distinct domains of the fission yeast nuclear envelope (NE), focusing on regions enriched for the
Hani Ebrahimi, Hirohisa Masuda, Devanshi Jain, Julia Promisel Cooper   +3 more
doaj   +1 more source

Inheritance of telomere length in a bird. [PDF]

PLoS ONE, 2011
Telomere dynamics are intensively studied in human ageing research and epidemiology, with many correlations reported between telomere length and age-related diseases, cancer and death. While telomere length is influenced by environmental factors there is
Thorsten Horn, Bruce C Robertson, Margaret Will, Daryl K Eason, Graeme P Elliott, Neil J Gemmell   +5 more
doaj   +1 more source

The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

Nature Communications, 2019
ALT telomeres experience DNA damage that may drive recombination-based telomere elongation. Here, the authors reveal that FANCM plays a critical role in the suppression of ALT activity through its interaction with the BTR (BLM-TOP3A-RMI) complex.
Robert Lu, Julienne J. O’Rourke, Alexander P. Sobinoff, Joshua A. M. Allen, Christopher B. Nelson, Christopher G. Tomlinson, Michael Lee, Roger R. Reddel, Andrew J. Deans, Hilda A. Pickett   +9 more
doaj   +1 more source

Stress exposure in early post-natal life reduces telomere length: an experimental demonstration in a long-lived seabird [PDF]

, 2014
Exposure to stressors early in life is associated with faster ageing and reduced longevity. One important mechanism that could underlie these late life effects is increased telomere loss. Telomere length in early post-natal life is an important predictor
Adam, Aileen, Boner, Winnie, Daunt, Francis, Heidinger, Britt J., Herborn, Katherine A., Monaghan, Pat, Noguera, Jose C.   +6 more
core   +4 more sources

AKTIP/Ft1, a new shelterin-interacting factor required for telomere maintenance [PDF]

, 2015
Telomeres are nucleoprotein complexes that protect the ends of linear chromosomes from incomplete replication, degradation and detection as DNA breaks. Mammalian telomeres are protected by shelterin, a multiprotein complex that binds the TTAGGG telomeric
A., Biroccio, A., Musio, Burla, Romina, Cacchione, Stefano, Carcuro, Mariateresa, Cenci, Giovanni, Ciapponi, Laura, E., Cundari, Galati, Alessandra, Gatti, Maurizio, LA TORRE, Mattia, Micheli, Emanuela, Raffa, GRAZIA DANIELA, Raimondo, Domenico, Rizzo, Angela, Saggio, Isabella   +15 more
core   +12 more sources

Author Correction: The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

Nature Communications, 2019
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Robert Lu, Julienne J. O’Rourke, Alexander P. Sobinoff, Joshua A. M. Allen, Christopher B. Nelson, Christopher G. Tomlinson, Michael Lee, Roger R. Reddel, Andrew J. Deans, Hilda A. Pickett   +9 more
doaj   +1 more source

Change in Leukocyte Telomere Length Predicts Mortality in Patients with Stable Coronary Heart Disease from the Heart and Soul Study. [PDF]

PLoS ONE, 2016
Short telomere length independently predicts mortality in patients with coronary heart disease. Whether 5-year change in telomere length predicts subsequent mortality in patients with coronary heart disease has not been evaluated.In a prospective cohort ...
Sarah E Goglin, Ramin Farzaneh-Far, Elissa S Epel, Jue Lin, Elizabeth H Blackburn, Mary A Whooley   +5 more
doaj   +1 more source

Telomere-to-telomere assembly of a complete human X chromosome

bioRxiv, 2019
After two decades of improvements, the current human reference genome (GRCh38) is the most accurate and complete vertebrate genome ever produced. However, no single chromosome has been finished end to end, and hundreds of unresolved gaps persist 1 , 2 ...
K. Miga, S. Koren, A. Rhie, Mitchell R. Vollger, Ariel Gershman, Andrey V. Bzikadze, Shelise Y. Brooks, Edmund Howe, David Porubsky, Glennis A. Logsdon, Valerie A. Schneider, T. Potapova, J. Wood, W. Chow, J. Armstrong, J. Fredrickson, E. Pak, Kristof Tigyi, Milinn Kremitzki, C. Markovic, Valerie V B Maduro, A. Dutra, G. Bouffard, Alexander M. Chang, Nancy F. Hansen, F. Thibaud-Nissen, A. Schmitt, Jon-Matthew Belton, Siddarth Selvaraj, M. Dennis, Daniela C. Soto, Ruta M Sahasrabudhe, Gulhan Kaya, J. Quick, N. Loman, N. Holmes, M. Loose, U. Surti, R. Risques, Tina A. Graves Lindsay, R. Fulton, Ira M. Hall, B. Paten, K. Howe, W. Timp, Alice C. Young, J. Mullikin, P. Pevzner, J. Gerton, B. Sullivan, E. Eichler, A. Phillippy   +51 more
semanticscholar   +1 more source

Is telomere length a biomarker for aging: cross-sectional evidence from the west of Scotland? [PDF]

, 2012
Background <p> The search for biomarkers of aging (BoAs) has been largely unsuccessful to-date and there is widespread skepticism about the prospects of finding any that satisfy the criteria developed by the American Federation of Aging Research ...
Alan McIntyre, G. David Batty, Gabriele Sorci, Geoff Der, Ian J. Deary, Liane McGlynn, Michael J. Green, Michaela Benzeval, Paul G. Shiels, Tony Robertson   +9 more
core   +21 more sources