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Genes, 2022 Telomeres are essential structures formed from satellite DNA repeats at the ends of chromosomes in most eukaryotes. Satellite DNA repeat sequences are useful markers for karyotyping, but have a more enigmatic role in the eukaryotic cell. Much work has been done to investigate the structure and arrangement of repetitive DNA elements in classical models ...
Leon P. Jenner +3 more
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Telomere length comparison between oral cells and blood cells among neonates
The Turkish Journal of Pediatrics, 2019 Telomere length, measured from blood cells, is commonly used as the standard telomere length of the whole body. The relationship between blood telomere length and oral telomere length is still unclear, especially among neonates.
Mandar Bhattacharya +2 more
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The JIL-1 kinase affects telomere expression in the different telomere domains of Drosophila. [PDF]
PLoS ONE, 2013 In Drosophila, the non-LTR retrotransposons HeT-A, TART and TAHRE build a head-to-tail array of repetitions that constitute the telomere domain by targeted transposition at the end of the chromosome whenever needed. As a consequence, Drosophila telomeres
Rute Silva-Sousa, Elena Casacuberta
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Telomeres susceptibility to environmental arsenic exposure: Shortening or lengthening?
Frontiers in Public Health, 2023 Maintaining telomere length plays a crucial role in regulating cellular life span. Telomere lengthening or shortening is one of the important biomarkers which could predict the preceding or present diseases. Meanwhile, the impact of environmental arsenic
Kyi Mar Wai +5 more
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Association of telomere instability with senescence of porcine cells
BMC Cell Biology, 2012 Background Telomeres are essential for the maintenance of genomic stability, and telomere dysfunction leads to cellular senescence, carcinogenesis, aging, and age-related diseases in humans. Pigs have become increasingly important large animal models for
Ji Guangzhen +4 more
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The EMBO Reports, 2002 Telomeres are protein-DNA complexes that cap chromosome ends and protect them from being recognized and processed as DNA breaks. Loss of capping function results in genetic instability and loss of cellular viability. The emerging view is that maintenance of an appropriate telomere structure is essential for function. Structural information on telomeric
Daniela, Rhodes +4 more
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Identification of Neuroblastoma Subgroups Based on Three-Dimensional Telomere Organization
Translational Oncology, 2016 Using 3D telomere quantitative fluorescence in situ hybridization, we determined the 3D telomere organization of 74 neuroblastoma tissue samples. Hierarchical cluster analysis of the measured telomere parameters identified three subgroups from our ...
Alexandra Kuzyk +2 more
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Telomere tracking from birth to adulthood and residential traffic exposure
BMC Medicine, 2017 Background Telomere attrition is extremely rapid during the first years of life, while lifestyle during adulthood exerts a minor impact. This suggests that early life is an important period in the determination of telomere length.
Esmée M. Bijnens +9 more
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Ecology and Evolution, 2023 Telomere length and telomere shortening are thought to be critical cellular attributes and processes that are related to an individual's life span and fitness.
David Gómez‐Blanco +2 more
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Telomeric recombination induced by dysfunctional telomeres
Molecular Biology of the Cell, 2011 Telomere maintenance is essential for cellular immortality, and most cancer cells maintain their telomeres through the enzyme telomerase. Telomeres and telomerase represent promising anticancer targets. However, 15% of cancer cells maintain their telomeres through alternative recombination-based mechanisms, and previous analyses showed that ...
Brault, Marie Eve, Autexier, Chantal
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