Results 21 to 30 of about 128,303 (302)

Trf1 is not required for proliferation or functional telomere maintenance in chicken DT40 cells [PDF]

, 2009
© 2009 by The American Society for Cell Biology.The telomere end-protection complex prevents the ends of linear eukaryotic chromosomes from degradation or inappropriate DNA repair. The homodimeric double-stranded DNA-binding protein, Trf1, is a component
Modino, S, Cooley, C, Cooley, C., Farr, CJ, Farr, C. J., Slijepcevic, P., Baird, K. M., Stewart, J. L., Slijepcevic, P, Baird, KM, Wenner, T., Stewart, JL, Faure, V., Morrison, C. G., Morrison, CG, Wenner, T, Modino, S., Faure, V, Stewart, Jillian, Faure, Virginie, Cooley, Carol, Morrison, Ciaran, Slijepcevic, Predrag, Wenner, Thomas, Farr, Christine, Modino, Sonie, Baird, Katie   +26 more
core   +1 more source

Investigation of telomere maintenance in BRCA2 defective mammalian cell lines [PDF]

, 2014
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel UniversityBRCA2 is a highly penetrant breast cancer predisposing gene.
Gozaly Chianea, Yaghoub
core   +6 more sources

Childhood obesity is associated with shorter leukocyte telomere length [PDF]

, 2011
CONTEXT: Obesity in adults is associated with shorter mean leukocyte telomere length (LTL), a marker of biological age that is also associated with age-related conditions including cardiovascular disease and type 2 diabetes. However, studies of childhood
Meyre, D, Buxton, Jessica L., Meyre, David, Buxton, JL, Walters, RG, Sophie Visvikis-Siest, Visvikis-Siest, S, Walters, Robin G., Jessica L. Buxton, Blakemore, AI, Visvikis-Siest, Sophie, David Meyre, Robin G. Walters, Alexandra I. F. Blakemore, Philippe Froguel, Blakemore, Alexandra I. F., Froguel, P, Froguel, Philippe   +17 more
core   +1 more source

Telomere Length and Physical Performance at Older Ages: An Individual Participant Meta-Analysis [PDF]

, 2013
Background Telomeres are involved in cellular ageing and shorten with increasing age. If telomere length is a valuable biomarker of ageing, then telomere shortening should be associated with worse physical performance, an ageing trait, but evidence ...
Hardy, R, John M. Starr (107707), Cooper, R, Rachel Cooper, von Zglinicki, Thomas, Halcyon study team, Parsons, Sam, Martin-Ruiz, C., Lennox, Alison, Kuh, D., Murray, Emily, Yoav Ben-Shlomo, Aihie Sayer, Avan, Shiels, Paul G, Thomas von Zglinicki, Martin, Richard, Carmen Martin-Ruiz (126509), Cooper Cyrus, Hardy, R., Hardy, Rachel, Deary, Ian, Gardner, M.P., Team, HS, Cooper, Cryus, von Zglinicki, T., Sayer Avan Aihie, John M Starr, Shiels, P.G., Ben-Shlomo, Yoav, Ian J. Deary (107724), Harris, Sarah E, Gardner, Michael, Sayer, AA, Day, Ian, team, Halcyon study, Sarah E Harris, Ian J Deary, Gallacher, J., Aucott, Paula, Harris, Sarah, Martin-Ruiz, C, Paul G Shiels, Gardner, MP, Southall, Humphrey, Kuh, Diana, Rebecca Hardy (188906), von Zglinicki Thomas, Deary, Ian J, Michael P. Gardner (381155), Goodwin, James, Michael P Gardner, Thomas von Zglinicki (73277), Yoav Ben-Shlomo (95286), Alfred, Tamuno, Cooper, C., Diana Kuh, Gallacher John, Ben-Shlomo, Y., Starr John M., Deary Ian J., Elliott, Jane, Cooper, C, Starr, J.M., Shiels, Paul G., Shiels, Paul, Rachel Cooper (188902), Shiels, PG, Harris Sarah E., Kuh Diana, Gallacher, John, Gardner, Michael P., Craig, Leone, Richards, Marcus, Starr, John M., John Gallacher, Mulla, Zeinab, Starr, John M, Gale, Catherine, Ben-Shlomo, Y, Carmen Martin-Ruiz, Demakakos, Panos, Gardner, Mike P, Cyrus Cooper (141250), Cooper, R., John Gallacher (196569), Sayer, A.A., Cyrus Cooper, Harris, S.E., Hardy, Rebecca, McNeill, Geraldine, Starr, JM, Harris, SE, ?, ?, Avan Aihie Sayer, Cooper, Rachel, Deary, IJ, Cooper Rachel, Gardner, Michael P, Avan Aihie Sayer (188916), Rebecca Hardy, Whalley, Lawrence, Shiels Paul G., Martin-Ruiz Carmen, Hardy Rebecca, Martin-Ruiz, Carmen, Deary, Ian J., Tilling, Kate, Harris, Sarah E., Gardner Michael P., Cooper, Cyrus, Power, Chris, Paul G. Shiels (125083), Sayer, Avan Aihie, Gallacher, J, Mishra, Gita, von Zglinicki, T, Kuh, D, von, Zglinicki T, Steptoe, Andrew, Ben-Shlomo Yoav, Sarah E. Harris (107676), Diana Kuh (188923), Starr, John, Deary, I.J.   +123 more
core   +1 more source

Author Correction: The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

Nature Communications, 2019
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Robert Lu, Julienne J. O’Rourke, Alexander P. Sobinoff, Joshua A. M. Allen, Christopher B. Nelson, Christopher G. Tomlinson, Michael Lee, Roger R. Reddel, Andrew J. Deans, Hilda A. Pickett   +9 more
doaj   +1 more source

Measuring telomere length and telomere dynamics in evolutionary biology and ecology [PDF]

, 2014
Telomeres play a fundamental role in the protection of chromosomal DNA and in the regulation of cellular senescence. Recent work in human epidemiology and evolutionary ecology suggests adult telomere length (TL) may reflect past physiological stress and ...
Barrett, Emma, Boner, Winnie, Hartmann, Nils, Nussey, Daniel H., Turbill, Christopher (R16915), Verhulst, Simon; id_orcid, Baird, Duncan Martin, Turbill, Chris, Leder, Erica, Monaghan, Pat, Olsson, Mats, Zahn, Sandrine, Horn, Thorsten, Verhulst, Simon, Haussmann, Mark, Gemmell, Neil, Fairlie, Jennifer, Baird, Duncan   +17 more
core   +2 more sources

Sir4 Deficiency Reverses Cell Senescence by Sub-Telomere Recombination

Cells, 2021
Telomere shortening results in cellular senescence and the regulatory mechanisms remain unclear. Here, we report that the sub-telomere regions facilitate telomere lengthening by homologous recombination, thereby attenuating senescence in yeast ...
Jun Liu, Xiaojing Hong, Lihui Wang, Chao-Ya Liang, Jun-Ping Liu   +4 more
doaj   +1 more source

Circulating leukocyte telomere length is highly heritable among families of Arab descent [PDF]

, 2012
Background Telomere length, an indicator of ageing and longevity, has been correlated with several biomarkers of cardiometabolic disease in both Arab children and adults.
Alokail Majed S, Shaun B Sabico, Assim A Alfadda, Sabico, Shaun, George P Chrousos, Omar S Al-Attas, Alokail, Majed S., Al-Attas, Omar S., Philip McTernan, Al-Daghri, Nasser M., Greg C Gibson, Al-Attas Omar S, Majed S Alokail, Gibson, Greg, Alkharfy Khalid M, Alfadda, Assim, Chrousos, George P., Gibson Greg C, Chrousos George P, McTernan Philip, Nasser M Al-Daghri, Sabico Shaun B, Al-Daghri Nasser M, Alfadda Assim A, Alkharfy, Khalid M., McTernan, P. G. (Philip G.), Khalid M Alkharfy   +26 more
core   +2 more sources

Telomeres in Fishes [PDF]

Cytogenetic and Genome Research, 2013
In fishes, as in other vertebrate species, the DNA component of the telomeres consists of the tandemly repeated TTAGGG motif. The length of the telomeric arrays in fishes ranges from 2 to 25 kb and shortens with age in some of the species. To date, chromosomal distribution of the telomeric DNA sequences has been examined in approximately 80 fish ...
openaire   +2 more sources

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source