Results 81 to 90 of about 130,635 (210)
Individual Telomere Lengths in Chronic Myeloid Leukemia
Neoplasia: An International Journal for Oncology Research, 2009 Chronic myeloid leukemia (CML) is a neoplasia characterized by proliferation of a myeloid cell lineage and chromosome translocation t(9;22) (q34;q11.2).
Oumar Samassekou +3 more
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Frontiers in Ecology and Evolution, 2019 Telomere length is a marker of cellular senescence that relates to different components of individual fitness. Oxidative stress is often claimed as a main proximate factor contributing to telomere attrition, although the importance of this factor in vivo
Lorenzo Pérez-Rodríguez +6 more
doaj +1 more source
Epiphenomenon of telomere lengths : lessons from ulcerative colitis [PDF]
, 2012 We read with great interest the article by Jones et al detailing TERC polymorphisms, longer telomeres and increased risk of colorectal cancer (CRC).1 Indeed, it is accepted that shorter telomere lengths (measured from peripheral leucocytes) have been ...
Arasaradnam, Ramesh P. +1 more
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Telomere-to-telomere genome assembly of sorghum
Scientific Data"Cuohu Bazi" (CHBZ) is an ancient sorghum variety collected from the fields of China, known for its agronomic traits like dwarf stature, early maturation. In this study, we present the first telomere-to-telomere (T2T) and gap-free genome assembly of CHBZ using PacBio HiFi reads, Oxford Nanopore Technologies, and Hi-C data.
Meng Li +9 more
openaire +3 more sources
Extensive telomere erosion is consistent with localised clonal expansions in Barrett's metaplasia.
PLoS ONE, 2017 Barrett's oesophagus is a premalignant metaplastic condition that predisposes patients to the development of oesophageal adenocarcinoma. However, only a minor fraction of Barrett's oesophagus patients progress to adenocarcinoma and it is thus essential ...
Boitelo T Letsolo +6 more
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Correlation of telomere length in brain tissue with peripheral tissues in living human subjects
Frontiers in Molecular NeuroscienceTelomeres are important to chromosomal stability, and changes in their length correlate with disease, potentially relevant to brain disorders. Assessing telomere length in human brain is invasive, but whether peripheral tissue telomere length correlates ...
Annemarie J. Carver +26 more
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Spontaneous telomere to telomere fusions occur in unperturbed fission yeast cells [PDF]
, 2013 Telomeres protect eukaryotic chromosomes from illegitimate end-to-end fusions. When this function fails, dicentric chromosomes are formed, triggering breakage-fusion-bridge cycles and genome instability.
Godinho Ferreira, M., Almeida, H.
core +1 more source
Neoplasia: An International Journal for Oncology Research, 1999 We have investigated a single telomere expansion in a case of acute lymphoblastic B-cell leukemia (B-ALL), where half of the cells in the bone marrow sample appeared with a Philadelphia chromosome. Comparing telomere sizes in Philadelphia-positive versus
Katerina Krejcí +2 more
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The EMBO Journal, 2009 The telomeres of most eukaryotes are characterized by guanine-rich repeats synthesized by the reverse transcriptase telomerase. Complete loss of telomerase is tolerated for several generations in most species, but modestly reduced telomerase levels in human beings are implicated in bone marrow failure, pulmonary fibrosis and a spectrum of other ...
openaire +2 more sources
Association between telomere shortening and ageing during occupational exposure [PDF]
Journal of Medical Biochemistry, 2012 Telomere length is considered as a biomarker of ageing, resulting in shortening during the process. The present investigation was an attempt to determine the relative telomere length in mechanical workshop workers.
Sima Ataollahi Eshkoor +5 more
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