Results 81 to 90 of about 116,824 (219)

Individual Telomere Lengths in Chronic Myeloid Leukemia

Neoplasia: An International Journal for Oncology Research, 2009
Chronic myeloid leukemia (CML) is a neoplasia characterized by proliferation of a myeloid cell lineage and chromosome translocation t(9;22) (q34;q11.2).
Oumar Samassekou, Aimé Ntwari, Josée Hébert, Ju Yan   +3 more
doaj   +1 more source

The TRF1 telomere protein is essential for the generation and maintenance of iPS cells and marks both pluripotent and adult stem cells [PDF]

, 2013
Englisch: Telomeres are nucleoprotein structures that protect the chromosomal ends from being recognized by DNA repair mechanisms as DNA double strand breaks. The Telomeric DNA is bound by various proteins that force the whole structure to fold in the so-
Schneider, Ralph Philipp
core   +1 more source

Correlation of telomere length in brain tissue with peripheral tissues in living human subjects

Frontiers in Molecular Neuroscience
Telomeres are important to chromosomal stability, and changes in their length correlate with disease, potentially relevant to brain disorders. Assessing telomere length in human brain is invasive, but whether peripheral tissue telomere length correlates ...
Annemarie J. Carver, Annemarie J. Carver, Annemarie J. Carver, Benjamin Hing, Benjamin Hing, Benjamin A. Elser, Benjamin A. Elser, Benjamin A. Elser, Stephanie J. Lussier, Stephanie J. Lussier, Stephanie J. Lussier, Takehiko Yamanashi, Takehiko Yamanashi, Takehiko Yamanashi, Takehiko Yamanashi, Matthew A. Howard, Matthew A. Howard, Hiroto Kawasaki, Hiroto Kawasaki, Gen Shinozaki, Gen Shinozaki, Gen Shinozaki, Hanna E. Stevens, Hanna E. Stevens, Hanna E. Stevens, Hanna E. Stevens, Hanna E. Stevens   +26 more
doaj   +1 more source

Vitamin E Supplementation—But Not Induced Oxidative Stress—Influences Telomere Dynamics During Early Development in Wild Passerines

Frontiers in Ecology and Evolution, 2019
Telomere length is a marker of cellular senescence that relates to different components of individual fitness. Oxidative stress is often claimed as a main proximate factor contributing to telomere attrition, although the importance of this factor in vivo
Lorenzo Pérez-Rodríguez, Lorenzo Pérez-Rodríguez, Tomás Redondo, Rocío Ruiz-Mata, Carlos Camacho, Gregorio Moreno-Rueda, Jaime Potti   +6 more
doaj   +1 more source

Modeling meiotic chromosomes indicates a size dependent contribution of telomere clustering and chromosome rigidity to homologue juxtaposition [PDF]

, 2012
Meiosis is the cell division that halves the genetic component of diploid cells to form gametes or spores. To achieve this, meiotic cells undergo a radical spatial reorganisation of chromosomes.
Penfold, Christopher A., Paul E Brown, Paul E. Brown (168021), Alastair S H Goldman, Christopher A. Penfold (168015), Neil D. Lawrence (168025), Penfold, C.A., Christopher A Penfold, Lawrence, Neil (Neil D.), Lawrence, N.D., Lawrence Neil D., Goldman Alastair S. H., Goldman, Alastair S. H., Alastair S. H. Goldman (168028), Brown Paul E., Neil D Lawrence, Penfold Christopher A., Brown, Paul E., Brown, P.E., Goldman, A.S.H.   +19 more
core   +1 more source

Extensive telomere erosion is consistent with localised clonal expansions in Barrett's metaplasia.

PLoS ONE, 2017
Barrett's oesophagus is a premalignant metaplastic condition that predisposes patients to the development of oesophageal adenocarcinoma. However, only a minor fraction of Barrett's oesophagus patients progress to adenocarcinoma and it is thus essential ...
Boitelo T Letsolo, Rhiannon E Jones, Jan Rowson, Julia W Grimstead, W Nicol Keith, Gareth J S Jenkins, Duncan M Baird   +6 more
doaj   +1 more source

Genome assembly in the telomere-to-telomere era

Nature Reviews Genetics
De novo assembly is the process of reconstructing the genome sequence of an organism from sequencing reads. Genome sequences are essential to biology, and assembly has been a central problem in bioinformatics for four decades. Until recently, genomes were typically assembled into fragments of a few megabases at best but technological advances in long ...
Heng Li, Richard Durbin
openaire   +4 more sources

TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres. [PDF]

, 2011
Shorter telomeres have been associated with increased risk of malignancy, including colorectal cancer (CRC). Telomere length is heritable and may be an intermediate phenotype linked to genetic susceptibility to ...
Tomlinson, IP, A M Jones, Beggs, A. D., Jones, A. M., M Walker, Jones, A.M., Dunlop, MG, Beggs, A.D., Tenesa, A., A D Beggs, Kerr, D, A Zauber, A Tenesa, Hodgson, S. V., Walker, M., M Bertagnolli, R Midgley, Carvajal-Carmona, L, Dunlop, Malcolm, Tenesa, Albert, Tenesa, A, Kerr, D., Jones, AM, Beggs, AD, M G Dunlop, Kerr, David, Jones, A M, Tomlinson, IPM, Carvajal-Carmona, L., Campbell, H.; id_orcid, Tomlinson, I P M, S Ballereau, Tomlinson, I. P. M., Zauber, A., S V Hodgson, Campbell, H, H Campbell, Farrington, S., Hodgson, SV, Ballereau, S., Campbell, H., Midgley, Rachel, Walker, M, S Farrington, I P M Tomlinson, Dunlop, M G, K Howarth, Farrington, S.; id_orcid, Howarth, K., Ballereau, S, Hodgson, S.V., Bertagnolli, M., Tomlinson, I.P., Beggs, A D; id_orcid, Midgley, R., D Kerr, Bertagnolli, M, L Carvajal-Carmona, Hodgson, S V, Dunlop, M. G., Midgley, R, Zauber, A, Howarth, K, Farrington, S   +63 more
core   +1 more source

Telomere-to-telomere genome assembly of sorghum

Scientific Data
"Cuohu Bazi" (CHBZ) is an ancient sorghum variety collected from the fields of China, known for its agronomic traits like dwarf stature, early maturation. In this study, we present the first telomere-to-telomere (T2T) and gap-free genome assembly of CHBZ using PacBio HiFi reads, Oxford Nanopore Technologies, and Hi-C data.
Meng Li, Chunhai Chen, Haigang Wang, Huibin Qin, Sen Hou, Xukui Yang, Jianbo Jian, Peng Gao, Minxuan Liu, Zhixin Mu   +9 more
openaire   +3 more sources

Spontaneous telomere to telomere fusions occur in unperturbed fission yeast cells [PDF]

, 2013
Telomeres protect eukaryotic chromosomes from illegitimate end-to-end fusions. When this function fails, dicentric chromosomes are formed, triggering breakage-fusion-bridge cycles and genome instability.
Godinho Ferreira, M., Almeida, H.
core   +1 more source