Results 101 to 110 of about 130,635 (210)

A mechanistic investigation into candidate markers of telomere-induced senescence in normal human epidermal keratinocytes [PDF]

, 2014
PhDTelomere dysfunction is one mechanism of cellular and tissue ageing. Dysfunctional telomeres in fibroblasts are recognised as DNA double-strand breaks (DSBs) and trigger the DNA damage pathway of senescence.
dos Santos Soares Martins de Castro, Alicia Maria
core   +1 more source

Telomere variant sequences encode the genetic blueprint for allele-specific telomere length

Nature Communications
The ends of human chromosomes are capped by specialized nucleoprotein structures, termed telomeres, which are essential for genome stability. Recent advances in long-read sequencing have enabled allele-specific telomere length measurements at nucleotide ...
Xiaoran Chai, LaiFong Poon, Hengrui Liu, Manvendra K. Singh, Takashi Minami, Goro Sashida, Masafumi Fukuda, Bin Tean Teh, Patrick Tan, William Ying Khee Hwang, Jue Lin, Angela S. Koh, Tatsuro Kondoh, Lifeng Xu, Motomi Osato, Jin Liu, Shang Li   +16 more
doaj   +1 more source

Telomeres [PDF]

Current Biology, 2001
openaire   +2 more sources

Est1p as a Cell Cycle-Regulated Activator of Telomere-Bound Telomerase

, 2009
In Saccharomyces cerevisiae, the telomerase components Est2p, TLC1 RNA, Est1p, and Est3p are thought to form a complex that acts late during chromosome replication (S phase) upon recruitment by Cdc13p, a telomeric DNA binding protein.
TENG, SHU-CHUN, 鄧述諄
core  

Telomeres and atherosclerosis.

Cardiovascular journal of Africa, 2012
In humans and other multicellular organisms that have an extended lifespan, the leading causes of death are atherosclerotic cardiovascular disease and cancer. Experimental and clinical evidence indicates that these age-related disorders are linked through dysregulation of telomere homeostasis.
Khan, Sajidah, NAIDOO, DATSHANA P, Chuturgoon, Anil A   +2 more
openaire   +2 more sources

ALTered telomeres in response to telomere dysfunction [PDF]

Cell Cycle, 2011
Marie Eve, Brault, Chantal, Autexier
openaire   +2 more sources

Replication Data for: Telomere dynamics, not absolute telomere length, predicts lifespan in adult zebra finches

This repository contains the data and code used for the analyses presented in the manuscript investigating the relationship between telomere length (TL), telomere shortening rate (ΔTL), and lifespan in adult captive zebra finches.
Tangili, Marianthi, Briga, Michael, Verhulst, Simon, Mulder, Ellis, Jimeno, Blanca   +4 more
core   +1 more source

Different phenotypes with different endings-Telomere biology disorders and cancer predisposition with long telomeres. [PDF]

Rare germline pathogenic variants (GPVs) in genes essential in telomere length maintenance and function have been implicated in two broad classes of human disease.
Bertuch, AA, Savage, SA, Team Telomere and the Clinical Care Consortium for Telomere‐Associated Ailments (CCCTAA)   +2 more
core   +1 more source

Digital telomere measurement by long-read sequencing distinguishes healthy aging from disease

Nature Communications
Telomere length is an important biomarker of organismal aging and cellular replicative potential, but existing measurement methods are limited in resolution and accuracy.
Santiago E. Sanchez, Yuchao Gu, Yan Wang, Anudeep Golla, Annika Martin, William Shomali, Dirk Hockemeyer, Sharon A. Savage, Steven E. Artandi   +8 more
doaj   +1 more source

Telomeres and telomere dysfunctions

Reviews in Biological and Biomedical Sciences, 2018
Elena Georgiana Dobre, Sorina Dinescu, Marieta Costache   +2 more
openaire   +1 more source