Results 101 to 110 of about 116,824 (219)

The Effect of Physical Activity agains the Telomere Length in the Leukocytes Cells of KONI Athletes

Biosaintifika: Journal of Biology & Biology Education, 2017
Telomeres are strands of non coding DNA at the ends of chromosomes that have the primary function to protect DNA from damage and maintain chromosomal stability.
Endang Purwaningsih, Titiek Djannatun, Etty Widayanti, Yulia Suciati, Yenni Zulhamidah   +4 more
doaj   +1 more source

A mechanistic investigation into candidate markers of telomere-induced senescence in normal human epidermal keratinocytes [PDF]

, 2014
PhDTelomere dysfunction is one mechanism of cellular and tissue ageing. Dysfunctional telomeres in fibroblasts are recognised as DNA double-strand breaks (DSBs) and trigger the DNA damage pathway of senescence.
dos Santos Soares Martins de Castro, Alicia Maria
core  

Telomeres in Fishes [PDF]

Cytogenetic and Genome Research, 2013
In fishes, as in other vertebrate species, the DNA component of the telomeres consists of the tandemly repeated TTAGGG motif. The length of the telomeric arrays in fishes ranges from 2 to 25 kb and shortens with age in some of the species. To date, chromosomal distribution of the telomeric DNA sequences has been examined in approximately 80 fish ...
openaire   +2 more sources

Repressive and non-repressive chromatin at native telomeres in Saccharomyces cerevisiae [PDF]

, 2009
Background In Saccharomyces cerevisiae genes that are located close to a telomere can become transcriptionally repressed by an epigenetic process known as telomere position effect.
Esther R Loney, Pryde, Fiona E., Louis Edward J, Pryde, FE, F. E. Pryde (7675940), Mellor, J., P. W. Inglis (7675937), Nicholas A Kent, J. Mellor (27566), Pryde Fiona E, Mellor Jane, Sharp Sarah, Kent Nicholas A, Loney, E. R., Sharp, Sarah, Sharp, S., Edward John Louis (7604981), Sharp, S, Kent, NA, S. Sharp (7639394), Inglis, Peter W., Louis, Edward J., Inglis, P. W., Inglis, PW, N. A. Kent (7675943), Peter W Inglis, Loney, Esther R., Kent, Nicholas A., Jane Mellor, Mellor, J, Edward J Louis, Pryde, F. E., Louis, E. J., Loney Esther R, Inglis Peter W, Loney, ER, Louis, EJ, E. R. Loney (7675934), Mellor, Jane, Fiona E Pryde, Sarah Sharp   +40 more
core   +1 more source

Telomere length in early childhood is associated with sex and ethnicity

Scientific Reports, 2019
Telomeres are repetitive DNA sequences at the end of chromosomes that function to protect chromosomes from degradation. Throughout the life course, telomere length decreases with age and is influenced by environmental factors and health conditions.
Kien Ly, Caroline Walker, Sarah Berry, Russell Snell, Emma Marks, Zaneta Thayer, Polly Atatoa-Carr, Susan Morton   +7 more
doaj   +1 more source

Ustilago maydis Trf2 ensures genome stability by antagonizing Blm-mediated telomere recombination: Fine-tuning DNA repair factor activity at telomeres through opposing regulations.

PLoS Genetics
TRF2 is an essential and conserved double-strand telomere binding protein that stabilizes chromosome ends by suppressing DNA damage response and aberrant DNA repair.
Shahrez Syed, Sarah Aloe, Jeanette H Sutherland, William K Holloman, Neal F Lue   +4 more
doaj   +1 more source

Different phenotypes with different endings-Telomere biology disorders and cancer predisposition with long telomeres. [PDF]

Rare germline pathogenic variants (GPVs) in genes essential in telomere length maintenance and function have been implicated in two broad classes of human disease.
Bertuch, AA, Savage, SA, Team Telomere and the Clinical Care Consortium for Telomere‐Associated Ailments (CCCTAA)   +2 more
core   +1 more source

Telomeres at a glance

Journal of Cell Science, 2012
The linearity of chromosomes creates two major problems for eukaryotic cells: the end-replication problem and the end-protection problem. The end-replication problem stems from the inherent inability of the replication machinery to fully duplicate linear templates.
openaire   +3 more sources

Biochemical analysis of proteins in the telomere maintenance pathway

, 2010
Eukaryotic linear chromosomes culminate in nucleoprotein structures designated telomeres. The terminal telomeric DNA consists of tandem repeats of a G-rich motif that is established and maintained by the action of the specialized reverse transcriptase ...
Dezwaan, Diane C.
core  

Leukocyte telomere length in the Thoroughbred racehorse

, 2018
Thoroughbred racehorses possess superior cardiorespiratory fitness levels and are at the pinnacle of athletic performance compared to other breeds of horses.
J. Denham, M. M. Denham, Denham, Michele M., Denham, Josh   +3 more
core   +1 more source