Results 111 to 120 of about 116,824 (219)

Telomeres [PDF]

Current Biology, 2001
openaire   +2 more sources

ALTered telomeres in response to telomere dysfunction [PDF]

Cell Cycle, 2011
Marie Eve, Brault, Chantal, Autexier
openaire   +2 more sources

Telomere-targeting anticancer drugs

, 2011
In normal somatic cells, telomere length decreases with each replication event, until a critical state of replicative senescence is reached. On the contrary, telomere maintenance is evident in all types of cancer cells.
PAGANO, BRUNO
core  

Telomere-associated AR in prostate cancer cells.

, 2019
(A-D) Actinomycin D-resistant AR is preferentially associated with telomeres. (A) Actinomycin D treatment facilitates immunofluorescent identification of AR at telomeres.
G. Prem-Veer Reddy (172735), Clara Hwang (172737), Evelyn R. Barrack (172729), Vidyavathi Reddy (6693914), Sahn-Ho Kim (5654101), Asm Iskander (4107394), George Divine (6693917), Mani Menon (172732)   +7 more
core   +1 more source

Expression of shelterin and shelterin-associated genes in breast cancer cell lines [PDF]

, 2014
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Mammalian telomeric DNA consists of tandem repeats of the sequence TTAGGG associated with a specialized set of proteins, known collectively as Shelterin ...
Motevalli, Azadeh
core  

A CPC-shelterin-BTR axis regulates mitotic telomere deprotection

Nature Communications
Telomeres prevent ATM activation by sequestering chromosome termini within telomere loops (t-loops). Mitotic arrest promotes telomere linearity and a localized ATM-dependent telomere DNA damage response (DDR) through an unknown mechanism.
Diana Romero-Zamora, Samuel Rogers, Ronnie Ren Jie Low, Scott G. Page, Blake J. E. Lane, Shunya Kosaka, Andrew B. Robinson, Lucy French, Noa Lamm, Fuyuki Ishikawa, Makoto T. Hayashi, Anthony J. Cesare   +11 more
doaj   +1 more source

Association between modifiable lifestyle factors and telomere length: a univariable and multivariable Mendelian randomization study

Journal of Translational Medicine
Background Telomere length has long been recognized as a valuable biomarker of aging and is inversely correlated with chronological age. Various lifestyle factors have been implicated in telomere shortening or preservation; however, the association ...
Miao Chen, Zhen Wang, Hongfei Xu, Peng Teng, Weidong Li, Liang Ma   +5 more
doaj   +1 more source

Est1p as a Cell Cycle-Regulated Activator of Telomere-Bound Telomerase

, 2009
In Saccharomyces cerevisiae, the telomerase components Est2p, TLC1 RNA, Est1p, and Est3p are thought to form a complex that acts late during chromosome replication (S phase) upon recruitment by Cdc13p, a telomeric DNA binding protein.
TENG, SHU-CHUN, 鄧述諄
core  

Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast.

PLoS Genetics, 2006
Telomere length-variation in deletion strains of Saccharomyces cerevisiae was used to identify genes and pathways that regulate telomere length. We found 72 genes that when deleted confer short telomeres, and 80 genes that confer long telomeres relative ...
doaj   +1 more source

Telomeres and telomere dysfunctions

Reviews in Biological and Biomedical Sciences, 2018
Elena Georgiana Dobre, Sorina Dinescu, Marieta Costache   +2 more
openaire   +1 more source