Results 91 to 100 of about 116,824 (219)

Association between telomere shortening and ageing during occupational exposure [PDF]

Journal of Medical Biochemistry, 2012
Telomere length is considered as a biomarker of ageing, resulting in shortening during the process. The present investigation was an attempt to determine the relative telomere length in mechanical workshop workers.
Sima Ataollahi Eshkoor, Fatemeh Jahanshiri, Patimah Ismail, Sabariah Abd Rahman, Moin Saidi, Mohd Yusoff Adon   +5 more
doaj  

Telomere-related genetic variants discovered in IPF cases by WES.

, 2020
Telomere-related genetic variants discovered in IPF cases by WES.
Joanne J. van der Vis (4720647), Roel Goldschmeding (50835), Matthijs F. M. van Oosterhout (4720653), Hendrik W. van Es (8259684), Aernoud A. van Batenburg (4720650), Karin M. Kazemier (8259681), Coline H. M. van Moorsel (8259690), Jan C. Grutters (8259687)   +7 more
core   +1 more source

TINF2 Gene Mutation in a Patient with Pulmonary Fibrosis

Case Reports in Pulmonology, 2016
Pulmonary fibrosis is a frequent manifestation of telomere syndromes. Telomere gene mutations are found in up to 25% and 3% of patients with familial disease and sporadic disease, respectively. The telomere gene TINF2 encodes an eponymous protein that is
T. W. Hoffman, J. J. van der Vis, M. F. M. van Oosterhout, H. W. van Es, D. A. van Kessel, J. C. Grutters, C. H. M. van Moorsel   +6 more
doaj   +1 more source

Molecular Cytogenetics Investigation of the Telomeres in a Case of Philadelphia Positive B-ALL with a Single Telomere Expansion

Neoplasia: An International Journal for Oncology Research, 1999
We have investigated a single telomere expansion in a case of acute lymphoblastic B-cell leukemia (B-ALL), where half of the cells in the bone marrow sample appeared with a Philadelphia chromosome. Comparing telomere sizes in Philadelphia-positive versus
Katerina Krejcí, Jesper Stentof, Jørn Koch   +2 more
doaj   +1 more source

Investigation of telomere maintenance in BRCA2 defective mammalian cell lines [PDF]

, 2014
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel UniversityBRCA2 is a highly penetrant breast cancer predisposing gene.
Gozaly Chianea, Yaghoub
core  

Effects of BRCA2 deficiency on telomere recombination in non-ALT and ALT cells

, 2011
This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2011 Sapir et al.Background: Recent studies suggest that BRCA2 affects telomere maintenance.
Slijepcevic, P, Yaghoub Gozaly-Chianea, Sainu Ravindran, Ravindran, S, Yasaei, H, Ester Sapir, Predrag Slijepcevic, Suliman Al-Wahiby, Hemad Yasaei, Gozaly-Chianea, Y, Sapir, E, Al-Wahiby, S   +11 more
core   +1 more source

TRF2 controls telomeric nucleosome organization in a cell cycle phase-dependent manner [PDF]

, 2012
Mammalian telomeres stabilize chromosome ends as a result of their assembly into a peculiar form of chromatin comprising a complex of non-histone proteins named shelterin.
Giraud-Panis, Marie-Josèphe, Marie-Josèphe Giraud-Panis, Giraud-Panis Marie-Josèphe, Giraud-Panis, M.J., Maria Savino (169324), Pinte, Sébastien, Maria Savino, Eric Gilson (139222), Colasanti, Valentina, Bauwens, Serge, Valentina Colasanti (169302), Pusch, Miriam Caroline, Stefano Cacchione, Bauwens Serge, Frédérique Magdinier (169297), Colasanti Valentina, Pinte Sébastien, Magdinier, Frédérique, Miriam Caroline Pusch, Gilson, Eric, Alessandra Galati, Pusch Miriam Caroline, Savino Maria, Ruggero Ricordy (169313), Gilson Eric, Serge Bauwens, M. J. Giraud Panis, Cacchione Stefano, Stefano Cacchione (169328), Magdinier Frédérique, Ruggero Ricordy, Eric Gilson, Frederique Magdinier, Sébastien Pinte (169308), Galati, Alessandra, Cacchione, Stefano, Sebastien Pinte, Marie-Josèphe Giraud-Panis (169317), Galati Alessandra, Savino, Maria, Miriam Caroline Pusch (169321), Valentina Colasanti, Ricordy, Ruggero, Ricordy Ruggero, Alessandra Galati (169293), Serge Bauwens (169304)   +45 more
core   +1 more source

Effect of chemotherapeutic drugs on telomere length and telomerase activity [PDF]

, 2020
Telomeres are specialized nucleoproteic complexes localized at the ends of eukaryotic chromosomes, that maintain their stability and integrity. They protect chromosome ends from fusion and from being recognized as sites of DNA damage, i.e., they ...
Bolzán, Alejandro Daniel
core  

Single telomere length analysis in Ustilago maydis, a high-resolution tool for examining fungal telomere length distribution and C-strand 5’-end processing [PDF]

, 2018
Telomeres play important roles in genome stability and cell proliferation. Telomere lengths are heterogeneous and because just a few abnormal telomeres are sufficient to trigger significant cellular response, it is informative to have accurate assays ...
Eun Young Yu, Neal F. Lue, Ganduri Swapna   +2 more
core   +1 more source

Correlation between telomere shortening in maternal peripheral blood and fetal aneuploidy

BMC Pregnancy and Childbirth
Background This study aimed to assess whether maternal telomere length is a more accurate predictor of trisomy 21 than maternal age while also exploring the factors influencing maternal and fetal telomere length.
Xiao-Xi Zhao, Le Le Bai
doaj   +1 more source