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Cold Spring Harbor Symposia on Quantitative Biology, 2010 Aneuploidy refers to karyotypic abnormalities characterized by gain or loss of individual chromosomes. This condition is associated with disease and death in all organisms in which it has been studied. We have characterized the effects of aneuploidy on yeast and primary mouse cells and found it to be detrimental at the cellular level.
Torres Mejia, Elen Raquel Sarabasti +3 more
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Journal of British Surgery, 1994 Abstract Aneuploidy is a state of abnormal and highly variable DNA and chromosome content found in both hereditary disorders and human malignancy. For two decades flow cytometry has allowed a wide-ranging survey of aneuploidy in clinicopathological series.
Rew, D. A.
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Genomic and Functional Approaches to Understanding Cancer Aneuploidy [PDF]
Cancer Cell, 2018 Aneuploidy, whole chromosome or chromosome arm imbalance, is a near-universal characteristic of human cancers. In 10,522 cancer genomes from The Cancer Genome Atlas, aneuploidy was correlated with TP53 mutation, somatic mutation rate, and expression of ...
Xiaoyang Zhang +2 more
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Cellular Stress Associated with Aneuploidy [PDF]
Developmental Cell, 2018 Aneuploidy, chromosome stoichiometry that deviates from exact multiples of the haploid compliment of an organism, exists in eukaryotic microbes, several normal human tissues, and the majority of solid tumors.
Jin Zhu, Hung-Ji Tsai
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Transcriptional consequences of aneuploidy [PDF]
Proceedings of the National Academy of Sciences, 2012 Aneuploidy, or an aberrant karyotype, results in developmental disabilities and has been implicated in tumorigenesis. However, the causes of aneuploidy-induced phenotypes and the consequences of aneuploidy on cell physiology remain poorly understood.
Sheltzer, Jason Meyer +3 more
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Current Biology, 2015 The terms 'haploid' and 'diploid' that describe single (n) and double (2n) chromosome sets in cells were coined by the Polish-German botanist Eduard Strasburger and originate from the Greek terms haplóos meaning 'single' and diplóos meaning 'double'.
Orr, Bernardo +2 more
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Aneuploidy facilitates dysplastic and tumorigenic phenotypes in the Drosophila gut [PDF]
, 2021 Aneuploidy has been strongly linked to cancer development, and published evidence has suggested that aneuploidy can have an oncogenic or a tumor suppressor role depending on the tissue context.
Brás, R +3 more
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Aneuploidy and tumorigenesis [PDF]
Seminars in Cell & Developmental Biology, 2011 Aneuploidy is a prominent phenotype of cancer. It refers to deviations from the normal number of chromosomes in a cell, as a result of whole-chromosome loss or gain. In most cases, aneuploidy is caused by mitotic errors due to defects in the mechanisms that have evolved to ensure faithful chromosome segregation, such as the spindle assembly checkpoint (
Xiao, Fang, Pumin, Zhang
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Mechanisms of aneuploidy [PDF]
Current Opinion in Cell Biology, 2011 Accurate chromosome segregation during cell division is essential for genome integrity. Errors in chromosome segregation are irreversible and lead to a state of aneuploidy where the number of chromosomes in a cell or organism is not a multiple of the haploid number of chromosomes.
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Aneuploidy in Health and Disease [PDF]
, 2012 Aneuploidy means any karyotype that is not euploid, anything that stands outside the norm. Two particular characteristics make the research of aneuploidy challenging.
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