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Cold Spring Harbor Symposia on Quantitative Biology, 2010 Aneuploidy refers to karyotypic abnormalities characterized by gain or loss of individual chromosomes. This condition is associated with disease and death in all organisms in which it has been studied. We have characterized the effects of aneuploidy on yeast and primary mouse cells and found it to be detrimental at the cellular level.
Torres Mejia, Elen Raquel Sarabasti +3 more
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Factors associated with de novo aneuploidy across different preimplantation genetic testing cycles: a retrospective cohort study [PDF]
Frontiers in EndocrinologyObjectivePrevious studies on factors influencing embryonic aneuploidy have produced inconsistent results. This study aimed to identify predictors of de novo aneuploidy in distinct patients undergoing preimplantation genetic testing for structural ...
Hongfang Liu +11 more
doaj +2 more sources
Aneuploidy and tumorigenesis [PDF]
Seminars in Cell and Developmental Biology, 2011 Aneuploidy is a prominent phenotype of cancer. It refers to deviations from the normal number of chromosomes in a cell, as a result of whole-chromosome loss or gain. In most cases, aneuploidy is caused by mitotic errors due to defects in the mechanisms that have evolved to ensure faithful chromosome segregation, such as the spindle assembly checkpoint (
Xiao, Fang, Pumin, Zhang
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Miscarriage history is not associated with embryonic aneuploidy in women under 38 years of age with recurrent pregnancy loss [PDF]
Frontiers in EndocrinologyPurposeThis study aimed to determine whether embryonic aneuploidy rates differ between patients with and without recurrent pregnancy loss (RPL).MethodsThis retrospective cohort study included 103 patients with RPL undergoing 128 preimplantation genetic ...
Sui-Bing Miao +5 more
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Infection and α-ketoglutarate/oxygen inhibition converge to CDC20 to promote cancer cell aneuploidy [PDF]
Signal Transduction and Targeted TherapyAneuploidy is pervasive in cancers and contributes to chemoresistance; however, how aneuploidy-inducing stresses, such as infection and hypoxia, promote chemoresistance remains unclear.
Yi-Neng Zhou +15 more
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Current Biology, 2015 The terms 'haploid' and 'diploid' that describe single (n) and double (2n) chromosome sets in cells were coined by the Polish-German botanist Eduard Strasburger and originate from the Greek terms haplóos meaning 'single' and diplóos meaning 'double'.
Orr, Bernardo +2 more
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Frontiers in Cell and Developmental Biology, 2022 Aneuploidy is widely identified as a remarkable feature of malignancy genomes. Increasing evidences suggested aneuploidy was involved in the progression and metastasis of prostate cancer (PCa). Nevertheless, no comprehensive analysis was conducted in PCa
Yun Peng, Yuxuan Song, Haitao Wang
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Frontiers in Immunology, 2022 Chromosome instability (CIN) and its major consequence, aneuploidy, are hallmarks of human cancers. In addition to imposing fitness costs on tumor cells through several cell-intrinsic mechanisms, CIN/aneuploidy also provokes an antitumor immune response.
Xiaohong Kuang, Jian Li
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Understanding How Genetic Mutations Collaborate with Genomic Instability in Cancer
Cells, 2021 Chromosomal instability is the process of mis-segregation for ongoing chromosomes, which leads to cells with an abnormal number of chromosomes, also known as an aneuploid state.
Laura J. Jilderda +2 more
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Exploiting aneuploidy-imposed stresses and coping mechanisms to battle cancer [PDF]
Open Biology, 2020 Aneuploidy, an irregular number of chromosomes in cells, is a hallmark feature of cancer. Aneuploidy results from chromosomal instability (CIN) and occurs in almost 90% of all tumours.
Lin Zhou +2 more
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