Aneuploidy facilitates dysplastic and tumorigenic phenotypes in the Drosophila gut [PDF]
Biology Open, 2021 Aneuploidy has been strongly linked to cancer development, and published evidence has suggested that aneuploidy can have an oncogenic or a tumor suppressor role depending on the tissue context.
Rita Brás +3 more
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Journal of British Surgery, 1994 Abstract Aneuploidy is a state of abnormal and highly variable DNA and chromosome content found in both hereditary disorders and human malignancy. For two decades flow cytometry has allowed a wide-ranging survey of aneuploidy in clinicopathological series.
Rew, D. A.
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The association between sperm aneuploidy and male infertility: Screening, aetiology and possible routes to alternative therapy [PDF]
, 2003 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.One in six couples wishing to start a family are infertile.
Tempest, Helen Ghislaine
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The muntjac spindle staining assay: An investigation of the ability of this assay to detect potential aneuploidy inducing agents [PDF]
, 1988 This thesis was submitted for the degree of Master of Philosophy and awarded by Brunel University.An assay using muntjac fibroblasts in conjunction with a differential spindle and chromosome stain was developed and evaluated for its ability to detect ...
Pascoe, Sally Ann
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Causes, consequences and clinical significance of aneuploidy across melanoma subtypes
Frontiers in Oncology, 2022 Aneuploidy, the state of the cell in which the number of whole chromosomes or chromosome arms becomes imbalanced, has been recognized as playing a pivotal role in tumor evolution for over 100 years.
Eva R. Shteinman +20 more
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Tissue engineering strategies for human hair follicle regeneration: How far from a hairy goal?
Stem Cells Translational Medicine, 2020 The demand for an efficient therapy for alopecia disease has fueled the hair research field in recent decades. However, despite significant improvements in the knowledge of key processes of hair follicle biology such as genesis and cycling, translation ...
Ana Rita Castro, Elsa Logarinho
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Mechanisms of aneuploidy [PDF]
Current Opinion in Cell Biology, 2011 Accurate chromosome segregation during cell division is essential for genome integrity. Errors in chromosome segregation are irreversible and lead to a state of aneuploidy where the number of chromosomes in a cell or organism is not a multiple of the haploid number of chromosomes.
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Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability
Nature Communications, 2017 Recent findings suggest that forces acting on the cell nucleus can cause DNA damage, but the mechanisms are unclear. Here Takakiet al. report that actomyosin is a determinant of nuclear shape and that unrestrained contractility elicits nuclear envelope ...
Tohru Takaki +10 more
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FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence
Nature Communications, 2018 Evidence for mitotic decline in aged cells and for aneuploidy-driven progression into full senescence is limited. Here, the authors find that in aged cells, mitotic gene repression leads to increased chromosome mis-segregation and aneuploidy that ...
Joana Catarina Macedo +9 more
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Ectopic expression of human TUBB8 leads to increased aneuploidy in mouse oocytes
Cell Discovery, 2023 Aneuploidy seriously compromises female fertility and increases incidence of birth defects. Rates of aneuploidy in human eggs from even young women are significantly higher than those in other mammals.
Jie Dong +9 more
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