Results 11 to 20 of about 47,394 (257)

FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence

Nature Communications, 2018
Evidence for mitotic decline in aged cells and for aneuploidy-driven progression into full senescence is limited. Here, the authors find that in aged cells, mitotic gene repression leads to increased chromosome mis-segregation and aneuploidy that ...
Joana Catarina Macedo, Sara Vaz, Bjorn Bakker, Rui Ribeiro, Petra Lammigje Bakker, Jose Miguel Escandell, Miguel Godinho Ferreira, René Medema, Floris Foijer, Elsa Logarinho   +9 more
doaj   +1 more source

Mechanisms of aneuploidy [PDF]

Current Opinion in Cell Biology, 2011
Accurate chromosome segregation during cell division is essential for genome integrity. Errors in chromosome segregation are irreversible and lead to a state of aneuploidy where the number of chromosomes in a cell or organism is not a multiple of the haploid number of chromosomes.
openaire   +2 more sources

Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability

Nature Communications, 2017
Recent findings suggest that forces acting on the cell nucleus can cause DNA damage, but the mechanisms are unclear. Here Takakiet al. report that actomyosin is a determinant of nuclear shape and that unrestrained contractility elicits nuclear envelope ...
Tohru Takaki, Marco Montagner, Murielle P. Serres, Maël Le Berre, Matt Russell, Lucy Collinson, Karoly Szuhai, Michael Howell, Simon J. Boulton, Erik Sahai, Mark Petronczki   +10 more
doaj   +1 more source

Ectopic expression of human TUBB8 leads to increased aneuploidy in mouse oocytes

Cell Discovery, 2023
Aneuploidy seriously compromises female fertility and increases incidence of birth defects. Rates of aneuploidy in human eggs from even young women are significantly higher than those in other mammals.
Jie Dong, Liping Jin, Shihua Bao, Biaobang Chen, Yang Zeng, Yuxi Luo, Xingzhu Du, Qing Sang, Tianyu Wu, Lei Wang   +9 more
doaj   +1 more source

Induced aneuploidy in neural stem cells triggers a delayed stress response and impairs adult life span in flies.

PLoS Biology, 2019
Studying aneuploidy during organism development has strong limitations because chronic mitotic perturbations used to generate aneuploidy usually result in lethality.
Mihailo Mirkovic, Leonardo G Guilgur, Alexandra Tavares, Diogo Passagem-Santos, Raquel A Oliveira   +4 more
doaj   +1 more source

Modulation of Aneuploidy in Leishmania donovani during Adaptation to Different In Vitro and In Vivo Environments and Its Impact on Gene Expression

mBio, 2017
Aneuploidy is usually deleterious in multicellular organisms but appears to be tolerated and potentially beneficial in unicellular organisms, including pathogens. Leishmania, a major protozoan parasite, is emerging as a new model for aneuploidy, since in
F. Dumetz, H. Imamura, M. Sanders, V. Seblova, J. Myskova, P. Pescher, M. Vanaerschot, C. J. Meehan, B. Cuypers, G. De Muylder, G. F. Späth, G. Bussotti, J. R. Vermeesch, M. Berriman, J. A. Cotton, P. Volf, J. C. Dujardin, M. A. Domagalska   +17 more
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Chromosomal Instability, Aneuploidy, and Gene Mutations in Human Sporadic Colorectal Adenomas

Cellular Oncology, 2004
Whether in vivo specific gene mutations lead to chromosomal instability (CIN) and aneuploidy or viceversa is so far not proven. We hypothesized that aneuploidy among human sporadic colorectal adenomas and KRAS2 and APC mutations were not independent ...
Walter Giaretti, Silvia Molinu, Jenny Ceccarelli, Claudia Prevosto   +3 more
doaj   +1 more source

Aneuploidy in the normal, Alzheimer's disease and ataxia-telangiectasia brain: Differential expression and pathological meaning

Neurobiology of Disease, 2009
Recently it has been suggested that the human brain contains aneuploid cells; however the nature and magnitude of neural aneuploidy in health and disease remain obscure. Here, we have monitored aneuploidy in the cerebral cortex of the normal, Alzheimer's
Ivan Y. Iourov, Svetlana G. Vorsanova, Thomas Liehr, Yuri B. Yurov   +3 more
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Selfish centromeres and the wastefulness of human reproduction.

PLoS Biology, 2022
Many human embryos die in utero owing to an excess or deficit of chromosomes, a phenomenon known as aneuploidy; this is largely a consequence of nondisjunction during maternal meiosis I.
Laurence D Hurst
doaj   +1 more source

Aneuploidy and confined chromosomal mosaicism in the developing human brain. [PDF]

PLoS ONE, 2007
BACKGROUND: Understanding the mechanisms underlying generation of neuronal variability and complexity remains the central challenge for neuroscience.
Yuri B Yurov, Ivan Y Iourov, Svetlana G Vorsanova, Thomas Liehr, Alexei D Kolotii, Sergei I Kutsev, Franck Pellestor, Alfia K Beresheva, Irina A Demidova, Viktor S Kravets, Viktor V Monakhov, Ilia V Soloviev   +11 more
doaj   +1 more source