Results 41 to 50 of about 63,250 (285)

DNA aneuploidy relationship with patient age and tobacco smoke in OPMDs/OSCCs.

PLoS ONE, 2017
The aim of this study was to investigate the relationship between tobacco smoke habit, patient age, DNA aneuploidy and genomic DNA copy number aberrations (CNAs) in oral potentially malignant disorder (OPMD) and oral squamous cell carcinoma (OSCC ...
Patrizio Castagnola, Sergio Gandolfo, Davide Malacarne, Cinzia Aiello, Roberto Marino, Gabriele Zoppoli, Alberto Ballestrero, Walter Giaretti, Monica Pentenero   +8 more
doaj   +1 more source

#291 : Association of Maternal Age with Embryonic Aneuploidy and Morphological Score Among Good-Prognosis Infertile Women: A Secondary Analysis of Multicenter, Randomized Controlled Trial

Fertility & Reproduction, 2023
Background and Aims: Maternal age has been reported to impact on embryo genetic status. However, current data on the association between maternal age and early embryo development are limited and inconclusive, especially among good-prognosis women.
Yumei Huang, Wei Zhou, Qian Zhang, Tianxiang Ni, Junhao Yan   +4 more
doaj   +1 more source

Germinal and somatic trisomy 21 mosaicism : how common is it, what are the implications for individual carriers and how does it come about? [PDF]

, 2010
It is well known that varying degrees of mosaicism for Trisomy 21, primarily a combination of normal and Trisomy 21 cells within individual tissues, may exist in the human population. This involves both Trisomy 21 mosaicism occurring in the germ line and
Maj Hulten, Jonasson, Jon,, Jon Jonasson, Ann Nordgren, Nordgren, Ann, Iwarsson, Erik,, Nordgren, Ann,, Iwarsson, Erik, Nordgren, A,, Jonasson, Jon, Erik Iwarsson, Hultén, Maj A., Jonasson, J, Hulten, MA, Iwarsson, E,, Hultén, Maj A,   +15 more
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Incidence of aneuploidy in embryos studied using PGT-A in Mexico: a clinical retrospective experience [PDF]

Revista Brasileira de Ginecologia e Obstetrícia
Objective: This study aimed to analyze the relationship between aneuploidy and maternal age based on preimplantation genetic testing for aneuploidies (PGT-A) and the distribution of aneuploidy across individual chromosomes.
Eduardo Ponce-Najera, Diana María Ojeda-López, Rodolfo González-Holveman, Ricardo Rodríguez-Calderon, Karla Patricia Bedia-Mejía, Jose Carlos Salazar-Trujillo, Jorge Luis Lezama-Ruvalcaba, Carlos Gerardo Salazar López-Ortiz   +7 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

The hidden costs of aneuploidy: New insights from yeast

Cell Genomics
The molecular mechanisms underlying the paradoxical effects1 of aneuploidy are still not completely understood. In this issue, Rojas et al.2 systematically analyzed the associated costs of aneuploidy and the molecular drivers involved, which revealed ...
Yuerong Wang, Xian Fu, Yue Shen
doaj   +1 more source

Aneuploidy: implications for protein homeostasis and disease

Disease Models & Mechanisms, 2014
It has long been appreciated that aneuploidy – in which cells possess a karyotype that is not a multiple of the haploid complement – has a substantial impact on human health, but its effects at the subcellular level have only recently become a focus of ...
Ana B. Oromendia, Angelika Amon
doaj   +1 more source

Real‐Time in Vivo Monitoring of Circulating Endometrial Cells: Uncovering Systemic Dissemination and Temporal Fluctuations in Endometriosis

Advanced Science, EarlyView.
A dual‐color pseudo‐menstrual mouse model enables real‐time tracing of circulating endometrial cells (CECs) from uterine and ectopic sources. The study reveals menstrual‐phase‐dependent, burst‐like CEC release, distinct postoperative behaviors of different CEC origins, and a potential association with prolactin fluctuations, providing an in vivo ...
Shang Wang, Chenyu Hou, Buyun Li, Hongyan Cheng, Xue Ye, Honglan Zhu, Yanmin Li, Rui Chen, Sihan Dong, Yi Li, Huiping Liu, Chen Zhang, Rui Zhang, Hongyi Hou, Xunbin Wei, Xiaohong Chang   +15 more
wiley   +1 more source