Results 21 to 30 of about 63,250 (285)
PLoS Biology, 2019 Studying aneuploidy during organism development has strong limitations because chronic mitotic perturbations used to generate aneuploidy usually result in lethality.
Mihailo Mirkovic +4 more
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mBio, 2017 Aneuploidy is usually deleterious in multicellular organisms but appears to be tolerated and potentially beneficial in unicellular organisms, including pathogens. Leishmania, a major protozoan parasite, is emerging as a new model for aneuploidy, since in
F. Dumetz +17 more
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Chromosomal Instability, Aneuploidy, and Gene Mutations in Human Sporadic Colorectal Adenomas
Cellular Oncology, 2004 Whether in vivo specific gene mutations lead to chromosomal instability (CIN) and aneuploidy or viceversa is so far not proven. We hypothesized that aneuploidy among human sporadic colorectal adenomas and KRAS2 and APC mutations were not independent ...
Walter Giaretti +3 more
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Neurobiology of Disease, 2009 Recently it has been suggested that the human brain contains aneuploid cells; however the nature and magnitude of neural aneuploidy in health and disease remain obscure. Here, we have monitored aneuploidy in the cerebral cortex of the normal, Alzheimer's
Ivan Y. Iourov +3 more
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Selfish centromeres and the wastefulness of human reproduction.
PLoS Biology, 2022 Many human embryos die in utero owing to an excess or deficit of chromosomes, a phenomenon known as aneuploidy; this is largely a consequence of nondisjunction during maternal meiosis I.
Laurence D Hurst
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Aneuploidy and confined chromosomal mosaicism in the developing human brain. [PDF]
PLoS ONE, 2007 BACKGROUND: Understanding the mechanisms underlying generation of neuronal variability and complexity remains the central challenge for neuroscience.
Yuri B Yurov +11 more
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Molecular signatures of aneuploidy-driven adaptive evolution
Nature Communications, 2020 Aneuploidy (abnormal chromosome number) can enable rapid adaptation to stress conditions, but it also entails fitness costs from gene imbalance. Here, the authors experimentally evolve yeast while forcing maintenance of aneuploidy to identify the ...
Alaattin Kaya +8 more
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Aneuploidy tolerance caused by BRG1 loss allows chromosome gains and recovery of fitness
Nature Communications, 2022 Aneuploidy results in decreased cellular fitness in many species and model systems. However, aneuploidy is commonly found in cancer cells and often correlates with aggressive growth, suggesting that the impact of aneuploidy on cellular fitness is context
Federica Schiavoni +7 more
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BMC Pregnancy and Childbirth, 2023 Background To compare the aneuploidy rate in spontaneous abortion chorionic villus (SA-CV) after D5 and D6 thawed-frozen blastocyst transfer(TBT). Methods This retrospective cohort study recruited 522 patients with early spontaneous abortion from March ...
Weie Zhao +5 more
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Quantitative proteomic analysis reveals posttranslational responses to aneuploidy in yeast
eLife, 2014 Aneuploidy causes severe developmental defects and is a near universal feature of tumor cells. Despite its profound effects, the cellular processes affected by aneuploidy are not well characterized. Here, we examined the consequences of aneuploidy on the
Noah Dephoure +6 more
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