Results 81 to 90 of about 93,154 (303)

Evaluation of predictive biomarkers for late radiation toxicity in breast cancer patients

Scientific Reports
Radiotherapy is administered to 70% of breast cancer patients, but late complications such as breast fibrosis remain a significant clinical concern. Individual variability significantly influences radiosensitivity, underscoring the need for predictive ...
Ángela Solana-Peña, Monica Pujol-Canadell, Miquel Macià, Evelyn Martínez Pérez, Isabel Linares, Milica Stefanovic, Héctor Pérez-Montero, Javier González-Viguera, Marina Arangüena Peñacoba, Montse Ventura, Ferran Guedea, Nadina Erill, Víctor González-Rumayor, Gemma Armengol, Joan Francesc Barquinero Estruch   +14 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Diagnostic Role of Chromosomal Instability in Melanoma

Journal of Skin Cancer, 2012
Early diagnosis gives melanoma patients the best chance for long term survival. However discrimination of an early melanoma from an unusual/atypical benign nevus can represent a significant challenge.
Nitika Dabas, Diana M. Byrnes, Ashley M. Rosa, Mark S. Eller, James M. Grichnik   +4 more
doaj   +1 more source

Chromosomal Instability Drives Metastasis Independent of Aneuploidy

, 2018
Chromosomal instability (CIN) promotes metastasis with little effect on primary tumor growth.

core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Clinicopathologic features of colorectal carcinoma: features predicting higher T-stage and nodal metastasis

BMC Research Notes, 2018
Objectives A rising frequency of colorectal carcinoma has been noted in recent years in Pakistan. In the present study, we aimed to evaluate clinicopathologic features of colorectal carcinoma in our population so that protocols could be developed to ...
Atif Ali Hashmi, Shumaila Kanwal Hashmi, Navaira Ali, Komal Thara, Rabia Ali, Muhammad Muzzammil Edhi, Naveen Faridi, Amir Khan   +7 more
doaj   +1 more source

Chromosomal instability in ataxia telangiectasia

Cancer Genetics and Cytogenetics, 1982
We have examined various aspects of lymphocyte chromosomal instability in three families comprised of five individuals affected with ataxiatelangiectasia (AT), their obligate heterozygous parents, and their unaffected sibs. We found that neither baseline sister chromatid exchanges (SCEs) nor mitomycin-C-induced increments in SCEs showed any significant
Department of Pediatrics, University of Florida, Gainesville, Florida USA. ( host institution ), Kohn, P.H. ( author ), Whang-Peng, J. ( author ), Levis, W.R. ( author )   +3 more
openaire   +3 more sources

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Chromosomal Instability in Chronic Myeloid Leukemia: Mechanistic Insights and Effects

, 2022
SIMPLE SUMMARY: Chronic myeloid leukemia is a disease diagnosed by the presence of the Philadelphia chromosome, which leads to the BCR::ABL fusion oncoprotein and overactive tyrosine kinase activity.
Senapati, Jayastu, Sasaki, Koji, Koji Sasaki, Jayastu Senapati   +3 more
core   +1 more source

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source