Results 31 to 40 of about 85,648 (260)

The mitotic origin of chromosomal instability [PDF]

Current Biology, 2014
SummaryChromosomal instability (CIN) is a common feature of most human neoplasms and was defined, in a seminal study by Vogelstein and colleagues [1], as persistently elevated rates of whole chromosome mis-segregation. Since then, it was shown that certain errors in mitosis, including defects in the spindle assembly checkpoint [2], sister chromatid ...
Bakhoum, Samuel F., Silkworth, William T., Nardi, Isaac K., Nicholson, Joshua M., Compton, Duane A., Cimini, Daniela   +5 more
openaire   +2 more sources

Chromosome instability in neuroblastoma.

Oncology letters, 2018
Neuroblastoma is a neural crest-derived tumor that accounts for 7-10% of all malignancies in children and ~15% of all childhood cancer-associated mortalities. Approximately 50% of patients are characterized as high-risk (HR) and have an overall survival of
Fusco, Pina, Esposito, Maria Rosaria, Tonini, Gian Paolo   +2 more
openaire   +2 more sources

Evidence of chromosomal instability in neurofibromatosis [PDF]

Cancer, 1985
Blood lymphocytes from six unrelated patients with neurofibromatosis and three normal controls were examined for their response to different doses (0, 75, 150, 300, 400 rad) of x-radiation, as measured by chromosome aberrations (gaps, breaks, dicentrics, centric rings, acentric ring, fragments, and minutes).
M, Hafez, L, Sharaf, S M, Abd el-Nabi, G, el-Wehedy   +3 more
openaire   +2 more sources

Molecular mechanism in a rare autosomal recessive case of xeroderma pigmentosum - a case report

National Journal of Clinical Anatomy, 2014
Chromosomal instability syndromes are a special group of disorders of cytogenetic interest which comprises of several rare, autosomal recessive conditions.
Vijaya Ramanathan, Anand Ramanathan
doaj   +1 more source

Tetraploidy causes chromosomal instability in acentriolar mouse embryos

Nature Communications, 2019
During cell division, tetraploidy can drive chromosomal instability (CIN) via supernumerary centrosomes, but it is unclear if this is the only route to CIN. Here the authors show that, in early mouse embryos, tetraploidy can drive chromosomal instability
Lia Mara Gomes Paim, Greg FitzHarris
doaj   +1 more source

DNA replication stress triggers rapid DNA replication fork breakage by Artemis and XPF. [PDF]

PLoS Genetics, 2018
DNA replication stress (DRS) leads to the accumulation of stalled DNA replication forks leaving a fraction of genomic loci incompletely replicated, a source of chromosomal rearrangements during their partition in mitosis.
Rémy Bétous, Théo Goullet de Rugy, Alessandra Luiza Pelegrini, Sophie Queille, Jean-Pierre de Villartay, Jean-Sébastien Hoffmann   +5 more
doaj   +1 more source

Nucleosome footprinting in plasma cell-free DNA for the pre-surgical diagnosis of ovarian cancer

npj Genomic Medicine, 2022
Fragmentation patterns of plasma cell-free DNA (cfDNA) are known to reflect nucleosome positions of cell types contributing to cfDNA. Based on cfDNA fragmentation patterns, the deviation in nucleosome footprints was quantified between diagnosed ovarian ...
Adriaan Vanderstichele, Pieter Busschaert, Chiara Landolfo, Siel Olbrecht, An Coosemans, Wouter Froyman, Liselore Loverix, Nicole Concin, Elena Ioana Braicu, Pauline Wimberger, Els Van Nieuwenhuysen, Sileny N. Han, Toon Van Gorp, Tom Venken, Ruben Heremans, Patrick Neven, Tom Bourne, Ben Van Calster, Dirk Timmerman, Diether Lambrechts, Ignace Vergote   +20 more
doaj   +1 more source

Mechanisms of chromosomal instability in melanoma [PDF]

Environmental and Molecular Mutagenesis, 2014
A systems biology approach was applied to investigate the mechanisms of chromosomal instability in melanoma cell lines. Chromosomal instability was quantified using array comparative genomic hybridization to identify somatic copy number alterations (deletions and duplications).
William K, Kaufmann, Craig C, Carson, Bernard, Omolo, Adam J, Filgo, Maria J, Sambade, Dennis A, Simpson, Janiel M, Shields, Joseph G, Ibrahim, Nancy E, Thomas   +8 more
openaire   +2 more sources

A role for polyploidy in the tumorigenicity of Pim-1-expressing human prostate and mammary epithelial cells. [PDF]

PLoS ONE, 2008
BackgroundPolyploidy is a prominent feature of many human cancers, and it has long been hypothesized that polyploidy may contribute to tumorigenesis by promoting genomic instability.
Meejeon Roh, Omar E Franco, Simon W Hayward, Riet van der Meer, Sarki A Abdulkadir   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source