Results 31 to 40 of about 93,154 (303)

PIGN spatiotemporally regulates the spindle assembly checkpoint proteins in leukemia transformation and progression

Scientific Reports, 2021
Phosphatidylinositol glycan anchor biosynthesis class N (PIGN) has been linked to the suppression of chromosomal instability. The spindle assembly checkpoint complex is responsible for proper chromosome segregation during mitosis to prevent chromosomal ...
Emmanuel K. Teye, Shasha Lu, Fangyuan Chen, Wenrui Yang, Thomas Abraham, Douglas B. Stairs, Hong-Gang Wang, Gregory S. Yochum, Robert A. Brodsky, Jeffrey J. Pu   +9 more
doaj   +1 more source

DNMTs are required for delayed genome instability caused by radiation [PDF]

, 2012
This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited ...
Anderson, Rhona, Iyer Pooja (7605638), Sandhu, J, Talbot, CJ, Jatinderpal Sandhu (2369116), Narayanan, D, Singh, Rajinder, Tufarelli, Cristina, Anderson, RM, Iyer, P, Deepan Narayanan (7605641), Sandhu, Jatinderpal, Tufarelli, C, Rajinder Singh (246689), Singh, R, George D. Jones (7605635), R. Anderson (3529871), Armstrong, CA, Christopher J. Talbot (7581152), Iyer, Pooja, Jones, GD, C Tufarelli (7605644), Narayanan, Deepan, Christine A. Armstrong (7605632), Armstrong, Christine A., Jones, George Tripp, Talbot, Christopher J.   +26 more
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Chromosomal Instability Is Associated with Higher Expression of Genes Implicated in Epithelial-Mesenchymal Transition, Cancer Invasiveness, and Metastasis and with Lower Expression of Genes Involved in Cell Cycle Checkpoints, DNA Repair, and Chromatin Maintenance

Neoplasia: An International Journal for Oncology Research, 2008
Chromosomal instability—a hallmark of epithelial cancers—is an ongoing process that results in aneuploidy and karyotypic heterogeneity of a cancer cell population.
Anna V. Roschke, Oleg K. Glebov, Samir Lababidi, Kristen S. Gehlhaus, John N. Weinstein, Ilan R. Kirsch   +5 more
doaj   +1 more source

Epigenetic Instability and Chromosomal Instability in Hepatocellular Carcinoma [PDF]

The American Journal of Pathology, 2006
The aim of this study was to clarify the association between the epigenetic instability phenotype and the chromosomal instability phenotype in primary hepatocellular carcinoma (HCC). Sixty primary HCC tumors were examined. Methylation status for nine CpG islands (the p16, COX2, GSTP1, RASSF1A, E-cadherin, and APC gene promoters, and the MINT 1, 25, and
Hiroto, Katoh, Tatsuhiro, Shibata, Akiko, Kokubu, Hidenori, Ojima, Masashi, Fukayama, Yae, Kanai, Setsuo, Hirohashi   +6 more
openaire   +2 more sources

In silico pathway analysis based on chromosomal instability in breast cancer patients

BMC Medical Genomics, 2020
Background Complex genomic changes that arise in tumors are a consequence of chromosomal instability. In tumor cells genomic aberrations disrupt core signaling pathways involving various genes, thus delineating of signaling pathways can help understand ...
Akeen Kour, Vasudha Sambyal, Kamlesh Guleria, Neeti Rajan Singh, Manjit Singh Uppal, Mridu Manjari, Meena Sudan   +6 more
doaj   +1 more source

Studying chromosome instability in the mouse [PDF]

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2008
Aneuploidy has long been recognized as one of the hallmarks of cancer. It nonetheless remains uncertain whether aneuploidy occurring early in the development of a cancer is a primary cause of oncogenic transformation, or whether it is an epiphenomenon that arises from a general breakdown in cell cycle control late in tumorigenesis.
Floris, Foijer, Viji M, Draviam, Peter K, Sorger   +2 more
openaire   +2 more sources

Chromosomal instability in cancer: Causes and consequences [PDF]

, 2001
Deep insight on Chromosomal instability in cancer: Causes and ...
Gisselsson, D, D Gisselsson
core   +1 more source

Dysregulated G2 phase checkpoint recovery pathway reduces DNA repair efficiency and increases chromosomal instability in a wide range of tumours

, 2021
Defective DNA repair is being demonstrated to be a useful target in cancer treatment. Currently, defective repair is identified by specific gene mutations, however defective repair is a common feature of cancers without these mutations.
Stevenson, Alexander J, Fernando, Madushan, Duijf, Pascal HG, Gabrielli, Brian, Ehmann, Anna, Proctor, Martina, Vora, Shivam, Adams, Mark, Skalamera, Dubravka   +8 more
core   +1 more source

Causes of Chromosomal Instability

, 2015
The majority of human cancer cells are highly aneuploid harboring chromosome numbers deviating from the modal number of 46. In cancer, aneuploidy is a consequence of an increased rate of whole chromosome missegregation during mitosis, a process known as chromosomal instability (CIN).
Bastians, Holger, Ghadimi, B. Michael, Ried, Thomas   +2 more
openaire   +3 more sources

TGFβ mediated chromosomal instability in human colorectal cancer cells [PDF]

, 2023
Chromosomal instability (CIN) is a major hallmark of human cancer and is defined as persistently high rate of the generation of chromosomal aberrations leading to genetic variability, tumour heterogeneity and tumour evolution.
Kaur, Simranjeet
core   +1 more source