Results 71 to 80 of about 55,696 (242)

Prenatal detection and outcome of major heart defects in a country with universal screening

Ultrasound in Obstetrics &Gynecology, EarlyView.
ABSTRACT Objective To evaluate the Danish prenatal screening program for major fetal congenital heart defects (mCHD), focusing on incidence, detection rates (DRs), pregnancy outcomes and postnatal mortality. Methods This was a 5‐year nationwide cohort study conducted from January 2018 to December 2022 in Denmark.
C. Vedel, J. Steensberg, O. B. Petersen, H. Andersen, M. Barbosa, M. Christiansen, V. Gjørup, A. N. Jensen, K. Munk, K. Nyborg, A. W. Olesen, F. Ravn, L. Sperling, H. G. H. Thyregod, N. Vejlstrup, C. K. Ekelund   +15 more
wiley   +1 more source

Aneuploidy in stem cells [PDF]

, 2016
Stem cells hold enormous promise for regenerative medicine as well as for engineering of model systems to study diseases and develop new drugs. The discovery of protocols that allow for generating induced pluripotent stem cells (IPSCs) from somatic cells
Foijer, Floris; id_orcid, Simon, Judith E, Bakker, Bjorn, Foijer, Floris, Schukken, Klaske M, Garcia-Martinez, Jorge, Bakker, Bjorn; id_orcid   +6 more
core   +1 more source

How to facilitate ultrasound examination of the fetal heart: the 5‐4‐3‐2‐1 method

Ultrasound in Obstetrics &Gynecology, EarlyView.
ABSTRACT We propose a new standardized, systematic method of fetal cardiac screening, the step‐by‐step ‘5‐4‐3‐2‐1’ method. This method is based on understanding the cardiac structures through a process of navigating between the different recommended views during an abdominothoracic sweep, following a user‐friendly checklist to identify the main ...
M. Levy, B. Stos
wiley   +1 more source

Left and right myocardial performance indices in growth‐restricted fetuses: systematic review and meta‐analysis

Ultrasound in Obstetrics &Gynecology, EarlyView.
ABSTRACT Objectives To evaluate alterations in fetal cardiac function in pregnancies complicated by fetal growth restriction (FGR) by synthesizing evidence on myocardial performance index (MPI) and its constituent parameters for both the left and right ventricles.
A. Sirico, I. Mappa, G. M. Maruotti, L. Cobellis, G. Rizzo   +4 more
wiley   +1 more source

One Yeast, Sixteen Synthetic Chromosomes, Infinite Possibilities

Yeast, EarlyView.
ABSTRACT The evolution of the yeast, Saccharomyces cerevisiae, from a genetically tractable model organism to a chassis for genome‐scale engineering represents one of the most influential trajectories in eukaryotic biology. The Synthetic Yeast Genome Project (Sc2.0) embodies the current height of this trajectory, having now delivered functional ...
Edward Archer, Roy S. K. Walker, Paige E. Erpf, Ian T. Paulsen, Isak S. Pretorius   +4 more
wiley   +1 more source

Reproductive Challenges of the Ageing Female: A Comprehensive Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Changes in societal norms over the last few decades have resulted in novel family planning trends, notably delayed childbearing and increased maternal age at the birth of the first child. Despite advances in reproductive medicine, ageing poses significant challenges.
Sofia Bitzika, Meletios P. Nigdelis, Angelos Daniilidis, Erich‐Franz Solomayer, Irene Lambrinoudaki, Efstratios M. Kolibianakis, Dimitrios G. Goulis   +6 more
wiley   +1 more source

Context is everything: aneuploidy in cancer

, 2020
Cancer is driven by multiple types of genetic alterations, which range in size from point mutations to whole-chromosome gains and losses, known as aneuploidy. Chromosome instability, the process that gives rise to aneuploidy, can promote tumorigenesis by
Amon, Angelika B, Ben-David, Uri
core   +1 more source

Hypermucinous Dysplasia in Inflammatory Bowel Disease (IBD): Morphology, Molecular Features, and Its Place in the IBD‐Associated Neoplastic Spectrum

Journal of Digestive Diseases, EarlyView.
This review provides the first comprehensive synthesis focused exclusively on hypermucinous dysplasia, summarizing its histopathologic definition, precursor lesions, clinicopathological associations, molecular features, and diagnostic reproducibility.
Ádám Ferenczi, Tamás Lantos, Anita Sejben   +2 more
wiley   +1 more source

Sperm Telomere Interactions Are Impaired in Testicular Cancer Before and After Adjuvant Therapy

Andrology, EarlyView.
ABSTRACT Background No study has yet explored telomere length or interaction in sperm nuclei of testicular cancer (TC) patients exposed to chemotherapy or radiotherapy. However, sperm telomere dynamics have emerged as a potential marker in male infertility.
Benoit Berby, Sylvianne Hennebicq, Jacqueline Saias, Florence Brugnon, Isabelle Berthaut, Myriam Daudin, Louis Bujan, Ludovic Dumont, Christine Rondanino, Aurélie Feraille, Nathalie Rives   +10 more
wiley   +1 more source

Identification of Aneuploidy-Tolerating Mutations

, 2010
Aneuploidy causes a proliferative disadvantage in all normal cells analyzed to date, yet this condition is associated with a disease characterized by unabated proliferative potential, cancer. The mechanisms that allow cancer cells to tolerate the adverse
Whittaker, Charles A., Amudha Panneerselvam, Tucker, Cheryl M., Cheryl M. Tucker, Amon, Angelika, Gygi, Steven P., Charles A. Whittaker, Amon, Angelika B, Steven P. Gygi, Torres, Eduardo M., Dunham, Maitreya J., Maitreya J. Dunham, Angelika Amon, Noah Dephoure, Torres, Eduardo Miguel, Torres, Eduardo Martin, Panneerselvam, Amudha, Dephoure, Noah, Eduardo M. Torres   +18 more
core   +1 more source