Results 101 to 110 of about 650,887 (390)

Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu, Zhihuang Zheng, Marleen Silke Oswald, Guozhe Cheng, Jun Liu, Qidi Zhai, Ute Kruegel, Michael Schaefer, Holger Gerhardt, Nicole Endlich, Maik Gollasch, Stefan Simm, Dmitry Tsvetkov   +12 more
wiley   +1 more source

Yersinia enterocolitica in Italy. A case of septicemia and abdominal aortic aneurysm infection [PDF]

, 2018
We report a case of Yersinia enterocolitica septicemia in a 63-year-old patient admitted to the Vascular Surgery Department of Umberto I Hospital (Rome, Italy) for an abdominal aortic aneurysm.
Alessia Bressan, Cecilia Ambrosi, Cecilia Ambrosi, Daniela Scribano, Donatella M. Rodio, Francesco Speziale, Guido Antonelli, Maria Trancassini, Rita Tolli, Valeria Pietropaolo, Wassim Mansour   +10 more
core   +2 more sources

Recurrent cerebrovascular events associated with patent foramen ovale, atrial septal aneurysm, or both.

New England Journal of Medicine, 2001
BACKGROUND Patent foramen ovale and atrial septal aneurysm have been identified as potential risk factors for stroke, but information about their effect on the risk of recurrent stroke is limited.
J. Mas, C. Arquizan, C. Lamy, M. Zuber, L. Cabanes, G. Derumeaux, J. Coste   +6 more
semanticscholar   +1 more source

Leptin Aggravates Thoracic Aortic Dissection Through Impairment of Energy Metabolism in Nrip2+ Smooth Muscle Cells

Advanced Science, EarlyView.
Epidemiological data confirm obesity elevates thoracic aortic dissection (TAD) risk. Patient analyses implicate hyperleptinemia, where leptin binding to vascular smooth muscle cell (VSMC) receptors triggers Socs3‐mediated suppression of Stat5a transcriptional activity.
Ling Chen, Yujie Zhu, Xi Yang, JiangBin Wu, Keyuan Chen, Wuqing Huang, Lu Fang, Qi Zhang, Jie Chen, Jianing Gao, Huanhuan Cao, Meifang Wu, Zhihuang Qiu, Yuling Zhang, Yue Shen, Qiuyu Huang, Zhiyong Lin, Lemin Zheng, Liangwan Chen   +18 more
wiley   +1 more source

ATF3 Deficiency Exacerbates Ageing‐Induced Atherosclerosis and Clinical Intervention Strategy

Advanced Science, EarlyView.
Targeting ATF3 with terazosin to against VSMC Senescence and atherosclerosis. TZ reduces the binding affinity of YTHDF2 to Atf3 mRNA, while enhancing mRNA stability. ATF3 promotes Atg7 transcription, enhancing autophagy. ATG7 binds to ATF3 in the cytoplasm, facilitating ATF3 translocation to the nucleus and establishing positive feedback. By modulating
Hao Nie, Tianyi Ji, Zixin Wan, Jie Huang, Han Li, Lingjiao Zou, Zhen Yang, Jiarui Li, Yuqi Guan, Lei Ruan, Jinhua Yan, Cuntai Zhang   +11 more
wiley   +1 more source

THE RELATIONSHIP OF THE MORPHOMETRIC CHARACTERISTICS OF RUPTURED CEREBRAL ANEURYSMS TO PATIENTS’ AGE

Вестник рентгенологии и радиологии, 2017
Objective. To investigate the morphological characteristics of ruptured aneurysms in a group of patients under and over 50 years of age. Material and methods.
A. L. Rogozin, I. E. Poverennova
doaj   +1 more source

The surgical intervention of thoracic aortic aneurysm among octogenarians and over: A Single center study

International Journal of Endorsing Health Science Research, 2020
Background: Thoracic endovascular aortic repair (TEVAR) is a minimally invasive procedure to repair the major blood vessel in the body i.e. aorta. This minimally invasive approach is considered as a better option in comparison to the open-heart surgery ...
Masato Furui, Shoji Sakaguchi, Kunwar Muhammad Aqeel Akhtar, Muhammad Imran, Bunpachi Kakii, Gaku Uchino, Mai Asanuma, Takeshi Yoshida   +7 more
doaj   +1 more source

An Aneurysm is Born [PDF]

Journal of the Royal Society of Medicine, 2003
is often quoted. The clinical diagnosis of botulism is confirmed by injection of the patient’s serum into a laboratory animal, which then shows signs of neurotoxicity. Seven serotypes of the toxin are known, but only types A, B and E have been consistently responsible for botulism in man and trivalent antitoxin directed at these is the treatment of ...
openaire   +3 more sources

Hyperhomocysteinemia induced by excessive methionine intake promotes rupture of cerebral aneurysms in ovariectomized rats. [PDF]

, 2016
BackgroundHyperhomocysteinemia (HHcy) is associated with inflammation and a rise in the expression of matrix metalloproteinase-9 (MMP-9) in the vascular wall.
Hashimoto, Tomoki, Kanematsu, Yasuhisa, Kitazato, Keiko T, Korai, Masaaki, Matsushita, Nobuhisa, Miyamoto, Takeshi, Nagahiro, Shinji, Satomi, Junichiro, Shimada, Kenji, Tada, Yoshiteru   +9 more
core   +2 more sources

Flow Conditions in the Intracranial Aneurysm Lumen Are Associated with Inflammation and Degenerative Changes of the Aneurysm Wall

American Journal of Neuroradiology, 2017
BACKGROUND AND PURPOSE: Saccular intracranial aneurysm is a common disease that may cause devastating intracranial hemorrhage. Hemodynamics, wall remodeling, and wall inflammation have been associated with saccular intracranial aneurysm rupture.
J. Cebral, Eliisa Ollikainen, B. Chung, F. Mut, V. Sippola, B. R. Jahromi, R. Tulamo, J. Hernesniemi, M. Niemelä, A. Robertson, J. Frösen   +10 more
semanticscholar   +1 more source