Results 31 to 40 of about 178,950 (268)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Treatment of arterial aneurysms of anterior cerebral circulation [PDF]

Vojnosanitetski Pregled, 2002
Objectives: To analyze the outcome of either surgical or conservative treatment of patients with aneurysms on cerebral arteries. Design Retrospective study on 114 patients (89 operated and 25 not operated). Methods: Clinical state was graded from 0 to V,
Roganović Zoran, Pavlićević Goran, Tadić Radenko   +2 more
doaj   +1 more source

TGFβ signaling pathways in human health and disease

Frontiers in Molecular Biosciences, 2023
Transforming growth factor beta (TGFβ) is named for the function it was originally discovered to perform-transformation of normal cells into aggressively growing malignant cells. It became apparent after more than 30 years of research, however, that TGFβ
Pei-Yu Chen, Lingfeng Qin, Michael Simons, Michael Simons   +3 more
doaj   +1 more source

High-resolution magnetic resonance imaging of intracranial aneurysms treated by flow diversion

Interdisciplinary Neurosurgery, 2017
Object: Flow diverter treatment of intracerebral aneurysms is highly successful and has low rates of morbidity and mortality. Among the primary concerns after endovascular treatment are failure to achieve aneurysm obliteration and recurrence, and close ...
Jian Guan, MD, Michael Karsy, MD, PhD, Scott McNally, MD, PhD, Adam de Havenon, MD, M. Yashar S. Kalani, MD, PhD, Philipp Taussky, MD, Seong-Eun Kim, PhD, Min S. Park, MD   +7 more
doaj   +1 more source

Investigating the Effect of Inclination Angle and the Influence of Scan Parameters on the Appearance and Thermal and Mechanical Properties of Filigree Tension Rods of LPBF‐Manufactured NiTi Shape‐Memory Alloys

Advanced Engineering Materials, EarlyView.
This article investigates the dependence of the properties on the manufacturing orientation in the form of the inclination angle to the build plate of LPBF‐fabricated NiTi rods with a diameter of 150–220 µm. Metallographic, chemical, thermal, and mechanical characterization show behavior under identical manufacturing conditions that ranges from ...
Sandra Herzig, Michael Werner, Christian Rotsch   +2 more
wiley   +1 more source

Arterial Spin Labeling Imaging of a Giant Aneurysm Leading to Subarachnoid Hemorrhage following Cerebral Infarction

Case Reports in Neurology, 2018
An 83-year-old Japanese man was admitted with dysarthria and right hemiparesis. He had had a large intracranial aneurysm on the left internal carotid artery 5 years before admission and had been followed up under conservative treatment.
Tatsuya Ueno, Tatsuya Sasaki, Masatoshi Iwamura, Tomoya Kon, Jin-ichi Nunomura, Hiroshi Midorikawa, Masahiko Tomiyama   +6 more
doaj   +1 more source

Computed Tomography‐ and Photoacoustic Imaging‐Active Bioresorbable Electrospun Bismuth Nanoparticle‐Infused Small‐Diameter Vascular Grafts

Advanced Healthcare Materials, EarlyView.
A polymeric graft loaded with radiopaque bismuth nanoparticles is expected to undergo gradual polymer resorption and nanoparticle release. This design enables noninvasive, multimodal monitoring of device integrity, patency, and degradation using computed tomography alongside ultrasound and photoacoustic imaging over 12 weeks.
Allan John R. Barcena, Joy Vanessa D. Perez, Marvin R. Bernardino, Dominic Karl M. Bolinas, Kitz Paul D. Marco, Kim Claudette J. Fernandez, Archana Mishra, Erin Marie D. San Valentin, Jossana A. Damasco, Gino Martin Canlas, Natalie Fowlkes, Richard R. Bouchard, Steven Y. Huang, Marites P. Melancon   +13 more
wiley   +1 more source

The Enterococcus-putrescine-hadh axis drives mitochondrial redox imbalance and endothelial barrier breakdown in aortic dissection

Redox Biology
Growing evidence indicates that gut microbiota-derived metabolites contribute to aortic dissection (AD), yet the molecular mechanisms linking microbial metabolism to endothelial barrier failure remain unclear.
Ding Wang, Di Di, Bo Jiang, Yunlong Wang, Zhenqi Jiang, Jiawei Zhang, Lei Wang, Xuan Li, Yuchen Jing, Baolong Liu, Huijing Zhang, Mingjun Sun, Shijie Xin   +12 more
doaj   +1 more source

Artificial Intelligence Meets Micro/Nanorobotics

Advanced Materials, EarlyView.
Artificial intelligence is transforming micro‐ and nanorobots from externally controlled, task‐specific machines into adaptive, autonomous systems. Machine learning, multimodal perception, digital twins, AI‐guided materials and geometry design enhance propulsion, localization, decision‐making, whichaccelerates clinical and environmental applications ...
Fatma M. Yurtsever, Minitha Cherukutty Ramakrishnan, Ian Kuula Ross, Ivan Zelinka, Hamed Shahsavan, Michal Otyepka, Martin Pumera   +6 more
wiley   +1 more source

Fast Hydrogel Micro‐Actuators Driven by Electric Fields

Advanced Materials, EarlyView.
We report the fabrication of chemically programmable electroactuating microstructures through the first integration of two‐photon polymerization with electrically actuated gelatin methacrylate‐based hydrogels. By tailoring the charge of the polymer network, we demonstrate programmable polarity‐dependent bending, enabling microstructures that ...
Annaël Sort‐Montenegro, Jason M. Delente, Žiga Roblek, Yekaterina Tskhe, Luke Dowling, Colm Delaney, Larisa Florea   +6 more
wiley   +1 more source