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Anti-rheumatoid Arthritis Mechanisms of Angelicae Pubescentis Radix

2019 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2019
Angelicase Pubescentis Radix (APR) has been used in the practices of traditional Chinese medicine (TCM) with anti-rheumatoid arthritis (RA) effects called “wind-dampness-dispelling and cold dispersing”. In TCM prescriptions and patient medicines, APR has been widely adopted against RA. Till now, the anti-rheumatoid mechanisms are still obscure. In this
Junping Zhan, Guang Zheng
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Screening and quantification of TNF-α ligand from Angelicae Pubescentis Radix by biosensor and UPLC-MS/MS

Analytical Biochemistry, 2020
The aim of this study is to establish a method for rapid screening of active ingredients targeting TNF-α from Chinese herbal medicines. Take Angelicae Pubescentis Radix (APR) as an example, surface plasma resonance technique was used to establish for screening small molecule inhibitors of TNF-α from APR extract. Then UPLC-MS/MS coupled with chemometric
Liu, Yang   +9 more
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Therapeutic effects of columbianadin from Angelicae Pubescentis radix on the progression of collagen-induced rheumatoid arthritis by regulating inflammation and oxidative stress

Journal of Ethnopharmacology, 2023
Angelicae pubescentis radix (APR) has a long history in the treatment of rheumatoid arthritis (RA) in China. It has the effects of dispelling wind to eliminate dampness, removing arthralgia and stopping pain in the Chinese Pharmacopeia, but its mechanisms was remained unclear.
Shujing, Chen   +9 more
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Extraction optimization of coumarins from radix angelicae pubescentis by HPLC-DAD coupled with uniform design

Journal of Central South University of Technology, 2006
Uniform design was used to optimize extraction condition of direct refluence extraction of coumarins from the Chinese traditional medicine of radix angelicae pubescentis(Duhuo); the sum peak area of coumarins separated with high performance liquid chromatography (HPLC) at detection wavelength of 320 nm was considered as detection index, two factors of ...
Fang-qiu Guo   +3 more
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[Purification technology of Rhizoma et Radix Notopterygii and Radix Angelicae Pubescentis in Fufang Xuelian dropping pills by macroporous resin].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2009
To study the purification technology of Rhizoma et Radix Notopterygii and Radix Angelicae Pubescentis in Fufang Xuelian dropping pills by macroporous resin.Taking osthole, isomperatorin as index ingredients, the type of resin sampling amount and elution solvent were decided, and the influence of sample concentration pH of sample and ratio of diameter ...
Yu-Qin, Luo   +3 more
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Pharmacokinetics and tissue distribution study of bisabolangelone from Angelicae Pubescentis Radix in rat using LC–MS/MS

Biomedical Chromatography, 2018
AbstractA sensitive and accurate LC–MS/MS method was established for quantifying bisabolangelone in rat plasma and tissues. Bisabolangelone was isolated and purified from Angelicae Pubescentis Radix. The pharmacokinetic and tissue distribution of bisabolangelone after administration to rat was performed by LC–MS/MS.
Yuanyuan Ge   +7 more
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Identification Analysis of Angelicae sinensis radix and Angelicae pubescentis radix Based on Quantized “Digital Identity” and UHPLC-QTOF-MSE Analysis

Journal of the American Society for Mass Spectrometry
Angelicae sinensis radix (ASR) and Angelicae pubescentis radix (APR), as traditional herbal medicines, are often confused and doped in the material market. However, the traditional identification method is to characterize the whole herb with a single or a few components, which do not have representation and cannot realize the effective utilization of ...
Xian rui Wang   +8 more
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Systematic analysis of the metabolites of Angelicae Pubescentis Radix by UPLC-Q-TOF-MS combined with metabonomics approaches after oral administration to rats

Journal of Pharmaceutical and Biomedical Analysis, 2020
Angelicae Pubescentis Radix (APR) is a typical Traditional Chinese Medicine (TCM) and has been widely used to treat rheumatism and headache diseases in China. This research aimed to illustrate the metabolites of APR in vivo to lay a foundation for the clinics application.
Mei-Qi, Wan   +7 more
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[GC-MS analysis of essential oils from Radix Angelicae Pubescentis].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2008
To analyze the constituents of the essential oils from Radix Angelicae Pubescentis planted in a GAP base of the Chinese medica materials, and provide the scientific basis for quality control.The essential oils were extracted by water-steam distillation and separated by GC capillary column chromatography.
Xiu-wei, Yang   +4 more
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Anthelmintic activity of the crude extracts, fractions, and osthole from Radix angelicae pubescentis against Dactylogyrus intermedius in goldfish (Carassius auratus) in vivo

Parasitology Research, 2010
A bioassay-guided fractionation was performed to evaluate the anthelmintic activity of the crude extract fractions and osthole from Radix angelicae pubescentis against Dactylogyrus intermedius in goldfish (Carassius auratus) in vivo. Among four extracts (petroleum ether, ethyl acetate, acetone, and ethanol), only ethanol extract exhibited the best ...
Kai-yu, Wang   +5 more
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