Results 101 to 110 of about 251,433 (257)

Reduced Graphene Oxide Enhances the Vascular Organization and Contractile Performance of Fibrin‐Gelatin‐Based Engineered Cardiac Tissue

Advanced Materials Interfaces, EarlyView.
Fibrin–gelatin hydrogels functionalized with reduced graphene oxide create a mechanically stable and bioactive 3D environment for engineered cardiac tissue. The composite matrix promotes endothelial lumen formation, enhances sarcomeric protein expression, and increases contractile performance of embedded cardiomyocytes.
Christoph Kuckelkorn, Marie Baiker, Yajuan Jiang, Ebru Aksoy, Kurt Pfannkuche, Horst Fischer   +5 more
wiley   +1 more source

A Critical Review on the Evolution of Chitosan‐Based Injectable Hydrogels in Bone Regeneration

Advanced Materials Interfaces, EarlyView.
The graphical illustration depicts hydrogel formulation using chitosan and biocompatible cross‐linkers, major advantages, and incorporation of cells, osteoinductive factors, and therapeutic drugs. Following injection, pH‐responsive gelation enables controlled drug release, promotes cell recruitment and osteogenic differentiation, enhances extracellular
Shivani Santosh Sakhrani, Abu ul Hassan S. Rana, S. Sudheer Khan   +2 more
wiley   +1 more source

Study of siRNA Delivery via Polymeric Nanoparticles in Combination with Angiogenesis Inhibitor for The Treatment of AFP-Related Liver Cancer. [PDF]

Int J Mol Sci, 2022
Punuch K, Wongwan C, Jantana S, Somboonyosdech C, Rodponthukwaji K, Kunwong N, Nguyen KT, Sirivatanauksorn V, Sirivatanauksorn Y, Srisawat C, Punnakitikashem P.   +10 more
europepmc   +1 more source

A Human Bone Defect‐on‐a‐Chip Model for Studying Bone Regeneration

Advanced Materials Technologies, EarlyView.
This study presents a novel human bone defect‐on‐a‐chip (BDOC) model, aiming to recapitulate key processes during early bone healing, incorporating bone graft substitutes. Over 21 days, human mesenchymal stem/stromal cells (HMSCs) and human primary macrophages are co‐cultured in the BDOC together with calcium phosphate microparticles.
Maria Gabriella Fois, Zeinab N. Tahmasebi Birgani, Francesca Giacomini, Alexander P. M. Guttenplan, David Baião Barata, Hoon Suk Rho, Noel Davison, Clemens van Blitterswijk, Martijn van Griensven, Stefan Giselbrecht, Pamela Habibović, Roman K. Truckenmüller   +11 more
wiley   +1 more source

Automated in vivo compound screening with zebrafish and the discovery and validation of PD 81,723 as a novel angiogenesis inhibitor. [PDF]

Sci Rep, 2022
Mauro AN, Turgeon PJ, Gupta S, Brand-Arzamendi K, Chen H, Malone JH, Ng R, Ho K, Dubinsky M, Di Ciano-Oliveira C, Spring C, Plant P, Leong-Poi H, Marshall JC, Marsden PA, Connelly KA, Singh KK.   +16 more
europepmc   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Loss of Brain Angiogenesis Inhibitor-3 (BAI3) G-Protein Coupled Receptor in Mice Regulates Adaptive Thermogenesis by Enhancing Energy Expenditure. [PDF]

Metabolites, 2023
Alsharif H, Latimer MN, Perez KC, Alexander J, Rahman MM, Challa AK, Kim JA, Ramanadham S, Young M, Bhatnagar S.   +9 more
europepmc   +1 more source

A Soft, Flexible Implant for Wireless Photothermal–Pyroelectric Neurostimulation

Advanced Science, EarlyView.
A replication strategy is used to enlarge the exposed surface area of barium titanate within flexible films with embedded carbon nanotubes, enabling efficient photothermal‐pyroelectric stimulation. Polar crystalline nanosheets show superior performance in guiding neural progenitor cells toward neuronal differentiation.
Jiang Wu, Minmin Mao, Beltzane Garcia Cirera, Hao Ye, Xiangzhong Chen, Josep Puigmartí‐Luis, Ni Qin, Salvador Pané   +7 more
wiley   +1 more source

Differential effects of cyclo-oxygenase 1 and 2 inhibition on angiogenesis inhibitor-induced hypertension and kidney damage. [PDF]

Clin Sci (Lond), 2022
Mirabito Colafella KM, van Dorst DCH, Neuman RI, Doorn LV, Neves KB, Montezano AC, Garrelds IM, van Veghel R, de Vries R, Uijl E, Clahsen-van Groningen MC, Baelde HJ, van den Meiracker AH, Touyz RM, Visser W, Danser AHJ, Versmissen J.   +16 more
europepmc   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source