Results 291 to 300 of about 209,193 (336)

Protamine is an inhibitor of angiogenesis

Nature, 1982
Protamine is shown to be a specific inhibitor of angiogenesis. The compound inhibits the capillary proliferation observed in embryogenesis, inflammation, certain immune reactions and the growth of solid tumours.
Judah Folkman, Stephanie Taylor
openaire   +2 more sources

Update on angiogenesis inhibitors

Current Opinion in Oncology, 2005
A number of therapeutic agents have been developed which have anti-angiogenic potential. Here we present the most recent data from clinical trials with some of the promising inhibitors of angiogenesis.Agents that target the vascular endothelial growth factor signaling pathway are the furthest along in clinical development.
Gerald A. Soff, Anaadriana Zakarija
openaire   +3 more sources

Perillyl Alcohol Is an Angiogenesis Inhibitor [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2004
Aberrant angiogenesis is essential for the progression of solid tumors and hematological malignancies. Thus, antiangiogenic therapy is one of the most promising approaches to control cancer. In the present work, we examined the ability of perillyl alcohol (POH), a dietary monoterpene with well-established tumor chemopreventive and chemotherapeutic ...
Loutrari, H., Hatziapostolou, M., Skouridou, V., Papadimitriou, E., Roussos, C., Kolisis, F.N., Papapetropoulos, A.   +6 more
openaire   +2 more sources

Maspin is an angiogenesis inhibitor

Nature Medicine, 2000
Maspin, a unique member of the serpin family, is a secreted protein encoded by a class II tumor suppressor gene whose downregulation is associated with the development of breast and prostate cancers. Overexpression of maspin in breast tumor cells limits their growth and metastases in vivo.
Olga V. Volpert, Yihui H. Shi, Noel P. Bouck, Ming Zhang   +3 more
openaire   +3 more sources

Inhibitors of Tumor Angiogenesis

2008
Inhibitors of Tumor ...
Harris, Adrian L, GENERALI, DANIELE
openaire   +3 more sources

Emoxypine as an inhibitor of angiogenesis

Bulletin of Experimental Biology and Medicine, 1992
The effect of emoxypin on angiogenesis in rabbit cornea in aseptic inflammation induced by intracorneal implantation of a piece of quartz and on the development of the vessels of the chick embryo yolk sac was studied. 1% emoxypin pipetted thrice a day for 10-14 days inhibited corneal neovascularization and reduced the formation of new blood vessels. We
A. A. Sologub, G. G. Ziangirova, S. I. Akberova   +2 more
openaire   +3 more sources

Metalloproteinases and their inhibitors in angiogenesis

Expert Reviews in Molecular Medicine, 2003
Angiogenesis, the formation of new blood vessels from the pre-existing vasculature, is an integral part of physiological processes such as embryonic development, the female reproductive cycle and wound healing. Angiogenesis is also central to a variety of pathologies including cancer, where it is recognised as being crucial for the growth of solid ...
Lafleur, M.A., Handsley, M.M., Edwards, D.R.   +2 more
openaire   +3 more sources

Heparin Derivatives as Angiogenesis Inhibitors

Current Pharmaceutical Design, 2003
Angiogenesis is the process of generating new capillary blood vessels. Uncontrolled endothelial cell proliferation is observed in tumor neovascularization and in angioproliferative diseases. Tumors cannot growth as a mass above few mm(3) unless a new blood supply is induced. It derives that the control of the neovascularization process may affect tumor
PRESTA, Marco, LEALI, Daria, STABILE H., RONCA, Roberto, CAMOZZI M., COCO L., MORONI E., LIEKENS S., RUSNATI, Marco   +8 more
openaire   +3 more sources

Thrombospondin as an Inhibitor of Angiogenesis [PDF]

, 1999
Most normal, healthy adult tissues exist in a state of vascular quiescence that is sustained by a combination of influences that include embryonic factors (1), associated cells (2) and an overall balance of angiogenic factors in which inhibitors predominate over inducers (3).
Noel P. Bouck, David W. Dawson
openaire   +1 more source

CURCUMIN AS AN INHIBITOR OF ANGIOGENESIS

2007
Angiogenesis, the formation of new blood vessels from host vasculature, is critical for tumor growth and metastases. -Curcumin, a novel small-molecular-weight compound, has been shown to inhibit carcinogenesis in different organs and the common link between these actions is its antiangiogenic effect.
Sulochana S. Bhandarkar, Jack L. Arbiser
openaire   +2 more sources