Results 141 to 150 of about 55,141 (338)

Cortical superficial siderosis and bleeding risk in cerebral amyloid angiopathy

Neurology, 2019
Objective To assess the association of cortical superficial siderosis (cSS) presence and extent with future bleeding risk in cerebral amyloid angiopathy (CAA).
A. Charidimou, G. Boulouis, S. Greenberg, A. Viswanathan   +3 more
semanticscholar   +1 more source

Synergistic effects of longitudinal amyloid and vascular changes on lobar microbleeds [PDF]

, 2016
OBJECTIVE: To determine whether amyloid and hypertensive cerebral small vessel disease (hCSVD) changes synergistically affect the progression of lobar microbleeds in patients with subcortical vascular mild cognitive impairment (svMCI).
Choe, YS, Jung, N-Y, Kim, HJ, Kim, JS, Kim, S, Kim, YJ, Kim, YJ, Kwak, K-C, Lee, J-H, Lee, JM, Lee, K-H, Moon, SH, Na, DL, Park, J-H, Seo, SW, Werring, DJ, Woo, S-Y   +16 more
core   +1 more source

Association of residential neighborhood disadvantage with amyloid PET positivity among cognitively impaired individuals

Alzheimer's &Dementia: Behavior &Socioeconomics of Aging, Volume 2, Issue 1, March 2026.
Abstract INTRODUCTION Relationships between Alzheimer's disease neuropathology, residential neighborhood, and cognitive impairment remain incompletely understood. METHODS We examined whether residence within a disadvantaged neighborhood was associated with amyloid positron emission tomography (PET) positivity.
Charles C. Windon, Elena Tsoy, Jennifer Livaudais‐Toman, Torsten B. Neilands, Nynikka R. Palmer, Margo B. Heston, Julene K. Johnson, Lucy Hanna, Constantine Gatsonis, Justin Romanoff, Jon Steingrimsson, Maria C. Carrillo, Peggye Dilworth‐Anderson, Bruce E. Hillner, Barry A. Siegel, Rachel A. Whitmer, Consuelo H. Wilkins, Karen Smith, Ganna Blazhenets, Renaud La Joie, Bruce L. Miller, Katherine L. Possin, Gil D. Rabinovici   +22 more
wiley   +1 more source

Monoclonal Antibody Identification of Subpopulations of Cerebral Cortical Neurons Affected in Alzheimer disease [PDF]

, 1987
Neuronal degeneration is one of the hallmarks of Alzheimer disease (AD). Given the paucity of molecular markers available for the identification of neuronal subtypes, the specificity of neuronal loss within the cerebral cortex has been difficult to ...
Blanks, Janet C., Hinton, David R., Kozlowski, Mark, Miller, Carol A., Rudnicka, Maria   +4 more
core  

Utilidad de las secuencias potenciadas en susceptibilidad paramagnética (SWI) para diferenciar crisis somestésicas de accidentes isquémicos transitorios en un paciente con angiopatía amiloide cerebral [PDF]

, 2011
Background. Cerebral amyloid angiopathy (CAA) is characterized by the deposit of β-amyloid on the walls of small and medium-sized arteries of the cerebral cortex and leptomeninges causing cerebral bleeding.
Garcia-de-Eulate, R. (Reyes), Gasca-Salas, C. (C.), Pastor, P. (Pau)   +2 more
core   +1 more source

Müller Glial Kir4.1 Channel Dysfunction in APOE4‐KI Model of Alzheimer's Disease

Glia, Volume 74, Issue 3, March 2026.
APOE4 impairs Müller cell health by reducing Kir4.1 expression and buffering. APOE4 causes mitochondrial dysfunction with decreased ΔΨm and increased ROS. MitoQ restores Kir4.1 expression and reduces ROS in APOE4‐transfected cells. ABSTRACT Alzheimer's disease (AD), particularly late‐onset AD (LOAD), affects millions worldwide, with the apolipoprotein ...
Surabhi D. Abhyankar, Yucheng Xiao, Neha Mahajan, Qianyi Luo, Theodore R. Cummins, Adrian L. Oblak, Bruce T. Lamb, Timothy W. Corson, Ashay D. Bhatwadekar   +8 more
wiley   +1 more source

Blood-Brain Barrier Leakage and Microvascular Lesions in Cerebral Amyloid Angiopathy

Stroke, 2019
Background and Purpose— Cerebral amyloid angiopathy (CAA) is a common small vessel disease that independently effects cognition in older individuals. The pathophysiology of CAA and CAA-related bleeding remains poorly understood. In this postmortem study,
W. Freeze, B. Bacskai, M. Frosch, H. Jacobs, W. Backes, S. Greenberg, Susanne J. van Veluw   +6 more
semanticscholar   +1 more source

Presenilin L166P Mutation, a Model of Familial Alzheimer's Disease, Leads to Early Onset Bone Loss

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
Female‐specific bone loss in Alzheimer's disease mouse models: There is a significant alteration of bone phenotype during Alzheimer's disease. Using integrated imaging and biological assays, we observed changes in the bone microarchitecture, composition, and function in PSEN K1 and PSEN1/hAPP Tg+ mice, predominantly in the females. ABSTRACT Accelerated
Vidyani Suryadevara, Connor J. Krehbial, Anuradha K. Valiya, Melinda Vang, Julian Balanta‐Melo, Pierre P. Eleniste, Sumana Posritong, Jung Min Hong, Katie Chester, Gabriel M. Pagnotti, Teresita Bellido, Monte S. Willis, Angela Bruzzaniti   +12 more
wiley   +1 more source

Effect of Aflatoxin B1 on the Nervous System: A Systematic Review and Network Analysis Highlighting Alzheimer’s Disease

Biology
Exposure to aflatoxin (AF) triggers the production of inflammatory molecules and free radicals, leading to chronic inflammation, cancer, and neurodegenerative diseases.
Samira Ranjbar, Pantea Mohammadi, Somayeh Pashaei, Masoud Sadeghi, Masomeh Mehrabi, Sasan Shabani, Ali Ebrahimi, Annette B. Brühl, Reza Khodarahmi, Serge Brand   +9 more
doaj   +1 more source

Immunotherapy with ponezumab for probable cerebral amyloid angiopathy

Annals of Clinical and Translational Neurology, 2019
Cerebral amyloid angiopathy (CAA) is caused by cerebrovascular deposition of β‐amyloid fragments leading to cerebrovascular dysfunction and other brain injuries.
C. Leurent, James A. Goodman, Yao Zhang, P. He, J. Polimeni, M. Gurol, Monica Lindsay, Linda Frattura, U. S. Sohur, A. Viswanathan, M. Bednar, Eric E. Smith, Charlotte David John Sandra Elizabeth Lawrence Sterling Cath Cordonnier Werring Black Honig Klijn Lee Restrepo, C. Cordonnier, D. Werring, S. Black, L. S. Honig, C. Klijn, Jin-moo Lee, L. Restrepo, C. Kase, S. Savitz, S. Greenberg   +22 more
semanticscholar   +1 more source