Results 31 to 40 of about 33,592 (159)

Safety and effectiveness of the anti‐amyloid monoclonal antibody (mAb) drug lecanemab for early Alzheimer's disease: The pharmacovigilance perspective

British Journal of Clinical Pharmacology, Volume 91, Issue 5, Page 1352-1360, May 2025.
Abstract The development of humanized IgG1 anti‐amyloid monoclonal antibodies, such as lecanemab, provides a promising novel treatment pathway with potential disease‐modifying effects for patients with early Alzheimer's disease (AD). Lecanemab, which gained marketing approval by the United States Food and Drug Administration (US FDA) in July 2023, has ...
Amy Bobbins, Miranda Davies, Elizabeth Lynn, Debabrata Roy, Alison Yeomans, Saad A. W. Shakir   +5 more
wiley   +1 more source

Applicability of in vivo staging of regional amyloid burden in a cognitively normal cohort with subjective memory complaints: the INSIGHT-preAD study. [PDF]

, 2019
BACKGROUND:Current methods of amyloid PET interpretation based on the binary classification of global amyloid signal fail to identify early phases of amyloid deposition.
Alzheimer Precision Medicine Initiative (APMI), Bertin, Hugo, Cavedo, Enrica, Dubois, Bruno, Dyrba, Martin, Gonzalez-Escamilla, Gabriel, Grothe, Michel J, Habert, Marie-Odile, Hampel, Harald, INSIGHT-preAD study group, Jelistratova, Irina, Lehericy, Stephane, Locatelli, Maxime, Sakr, Fatemah A, Teipel, Stefan   +14 more
core   +3 more sources

Amyloid‐Related Imaging Abnormality (ARIA) Beyond the APOE‐ε4 Allele

Chronic Diseases and Translational Medicine, EarlyView.
Mechanism of action of monoclonal antibodies targeting Aβ in the treatment of AD. (A) Targets of various mAbs. (B) Mechanism of monoclonal antibody‐mediated clearance of Aβ. mAbs facilitate the clearance of Aβ by enhancing microglial‐mediated phagocytosis through the upregulation of TREM2 expression.
Valentinus Besin, Farizky Martriano Humardani, Fenny Lanawati Yudiarto, Paulus Anam Ong, Sulistyo Emantoko Dwi Putra, Ratih Asmana Ningrum   +5 more
wiley   +1 more source

Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo. [PDF]

, 2009
Amyloid imaging represents a major advance in neuroscience, enabling the detection and quantification of pathologic protein aggregations in the brain. In this review we survey current amyloid imaging techniques, focusing on positron emission tomography ...
Jagust, WJ, Rabinovici, GD
core   +2 more sources

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi, Maria Giulia Bellicini, Marianna Adamo, Andrea Pilotto, Marco Metra, Alessandro Padovani, Riccardo Proietti   +6 more
wiley   +1 more source

Cerebral amyloid angiopathy in the elderly [PDF]

Annals of Neurology, 2011
AbstractCerebral amyloid angiopathy (CAA) results from deposition of β‐amyloid in the media and adventitia of small arteries and capillaries of the leptomeninges and cerebral cortex and is a major cause of lobar intracerebral hemorrhage and cognitive impairment in the elderly.
Anand Viswanathan, Steven M. Greenberg
openaire   +3 more sources

Familial multiple cavernous malformation syndrome : MR features in this uncommon but silent threat [PDF]

, 2016
Cerebral cavernous malformations (CCM) are vascular malformations in the brain and spinal cord. The familial form of cerebral cavernous malformation (FCCM) is uncommon.
Lemmerling, Marc, Mespreuve, Marc, Vanhoenacker, Filip   +2 more
core   +3 more sources

The Diagnostic Value of Contrast‐Enhanced Vessel Wall MRI for Diagnosing Neuropsychiatric Systemic Lupus Erythematosus

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Imaging biomarkers for neuropsychiatric systemic lupus erythematosus (NPSLE) are highly needed, and intracranial contrast‐enhanced vessel wall imaging (CE‐VWI) can potentially detect cerebral vessel wall abnormalities in lupus. Purpose To evaluate the diagnostic value of CE‐VWI in differentiating NPSLE from non‐NPSLE.
Satoru Ide, Yuya Fujita, Yu Murakami, Koichiro Futatsuya, Yuta Yoshimatsu, Jun Tsukamoto, Haruka Oku, Toshihiro Sakamoto, Yoshiya Tanaka, Takatoshi Aoki   +9 more
wiley   +1 more source

Post-Varicella Angiopathy

Pediatric Neurology Briefs, 2001
A 4-year-old male child who presented with right middle cerebral artery (MCA) infarction 2 months after varicella is reported from the University of British Columbia, Childrens Hospital, Vancouver, Canada.
openaire   +4 more sources

Naturally occurring autoantibodies against beta-amyloid: investigating their role in transgenic animal and in vitro models of Alzheimer's disease [PDF]

, 2011
Alzheimer's disease (AD) is a neurodegenerative disorder primarily affecting regions of the brain responsible for higher cognitive functions. Immunization against β-amyloid (Aβ) in animal models of AD has been shown to be effective on the molecular level
Al-Abed, Yousef, Andrei-Selmer, Luminita-Cornelia, Bacher, Michael, Balakrishnan, Karthikeyan, Balzer-Geldsetzer, Monika, Deuster, Oliver, Dodel, Richard, Du, Yansheng, Keyvani, Kathy, Neff, Frauke, Noelker, Carmen, Oertel, Wolfgang, Röskam, Stephan, Stüer, Carsten   +13 more
core   +1 more source