Results 41 to 50 of about 42,626 (296)

Effects of DPP4 Inhibitors as Neuroprotective Drug on Cognitive Impairment in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis and Systematic Review

International Journal of Endocrinology
Purpose. Type 2 diabetes mellitus is considered as one of the risk factors for cognitive impairment. DPP4 inhibitors are effective drugs for the treatment of type 2 diabetes mellitus.
Yuting Yuan, Yue Zhang, Min Lei, Xiying Guo, Xiaosong Yang, Changhan Ouyang, Chao Liu, Qingjie Chen   +7 more
doaj   +1 more source

Drugs for treating myocardial fibrosis

Frontiers in Pharmacology, 2023
Myocardial fibrosis, which is a common pathological manifestation of many cardiovascular diseases, is characterized by excessive proliferation, collagen deposition and abnormal distribution of extracellular matrix fibroblasts.
Zhanhong Ren, Zixuan Zhang, Zixuan Zhang, Li Ling, Xiufen Liu, Xin Wang   +5 more
doaj   +1 more source

Microvascular Health as a Key Determinant of Organismal Aging

Advanced Science, EarlyView.
This review spotlights the emerging field of vascular aging, providing a comprehensive and critical overview of the molecular processes and clinical manifestations of vascular dysfunction during aging. By combining basic angioscience concepts with a critical analysis of innovative pre‐clinical aging models and lifestyle interventions, it offers a ...
Mattia Cenciarini, Andrea Uccelli, Francesca Mangili, Myriam Grunewald, Simone Bersini   +4 more
wiley   +1 more source

Cerebral Amyloid and Hypertension are Independently Associated with White Matter Lesions in Elderly. [PDF]

, 2015
In cognitively normal (CN) elderly individuals, white matter hyperintensities (WMH) are commonly viewed as a marker of cerebral small vessel disease (SVD).
Alzheimer’s Disease Neuroimaging Initiative, Braskie, Meredith N, Carmichael, Owen T, DeCarli, Charles, Scott, Julia A, Thompson, Paul M, Tosun, Duygu, Weiner, Michael   +7 more
core   +2 more sources

Screening for Familial APP Mutations in Sporadic Cerebral Amyloid Angiopathy [PDF]

, 2010
Background Advances in genetic technology have revealed that variation in the same gene can cause both rare familial and common sporadic forms of the same disease.
A Rovelet-Lecrux, AL Gloyn, Alessandro Biffi, Anna Plourde, B Rosner, C Nilsberth, Christoph Winkler, Claudia M. Prada, D Woo, DA Nickerson, E Bakker, EE Smith, Eric E. Smith, James Gusella, JC Cohen, JC Florez, Jonathan Rosand, JP Vonsattel, KA Knudsen, L Hendriks, L Miravalle, L Obici, M Vaxillaire, Matthew Frosch, MS Fernando, Robert Onofrio, SM Greenberg, Steven M. Greenberg, SX Zhang-Nunes, TJ Grabowski, Yiping Shen, YW Chen   +31 more
core   +9 more sources

Research progress of brain organoids in the field of diabetes

Molecular Brain
Human embryonic stem cells and human induced pluripotent stem cells may be used to create 3D tissues called brain organoids. They duplicate the physiological and pathological characteristics of human brain tissue more faithfully in terms of both ...
Ying Su, Aimei Liu, Hongguang Chen, Qingjie Chen, Bo Zhao, Runze Gao, Kangwei Zhang, Tie Peng, Zhenwang Zhang, Changhan Ouyang, Dan Zhu   +10 more
doaj   +1 more source

Association of antithrombotic therapy with postoperative rebleeding in patients with cerebral amyloid angiopathy

Chinese Neurosurgical Journal, 2023
Background Cerebral amyloid angiopathy is a common cause of subcortical hemorrhage in older adults. Although open hematoma removal may be performed for severe subcortical hemorrhage, its safety in patients with cerebral amyloid angiopathy has not been ...
Taro Yanagawa, Hiroki Sato, Kaima Suzuki, Hidetoshi Ooigawa, Masaki Takao, Hiroki Kurita   +5 more
doaj   +1 more source

Clinical–Radiological Spectrum of Cerebral Amyloid Angiopathy‐Related Inflammation

Annals of Neurology, EarlyView.
Objective To identify clinical and radiological features of cerebral amyloid angiopathy‐related inflammation (CAA‐ri), and compare these features with those of sporadic CAA, to improve the understanding, diagnosis, and clinical care of CAA‐ri. Methods We retrospectively reviewed routine clinical data from 37 patients with CAA‐ri and 158 patients with ...
Larysa Panteleienko, Gargi Banerjee, Dermot Mallon, Kitti Thiankhaw, Rupert Oliver, Victoria Harvey, Gareth Ambler, Michael Zandi, Hans Rolf Jäger, David J. Werring   +9 more
wiley   +1 more source

Naturally occurring autoantibodies against beta-amyloid: investigating their role in transgenic animal and in vitro models of Alzheimer's disease [PDF]

, 2011
Alzheimer's disease (AD) is a neurodegenerative disorder primarily affecting regions of the brain responsible for higher cognitive functions. Immunization against β-amyloid (Aβ) in animal models of AD has been shown to be effective on the molecular level
Al-Abed, Yousef, Andrei-Selmer, Luminita-Cornelia, Bacher, Michael, Balakrishnan, Karthikeyan, Balzer-Geldsetzer, Monika, Deuster, Oliver, Dodel, Richard, Du, Yansheng, Keyvani, Kathy, Neff, Frauke, Noelker, Carmen, Oertel, Wolfgang, Röskam, Stephan, Stüer, Carsten   +13 more
core   +1 more source

Some aspects of morphogenesis of diabetic encephalopathy

Zaporožskij Medicinskij Žurnal, 2013
On the basis of the literary data and conducted large-scale research it was ascertained that diabetes mellitus raises the risk of cerebral stroke in 2-6 times, the risk of transitional ischemic attacks in 3 times in comparison with the same risk in the ...
V. A. Tumanskiy, Yu. N. Avramenko
doaj   +1 more source