Results 41 to 50 of about 33,592 (159)

Breaking Boundaries: Chronic Diseases and the Frontiers of Immune Microenvironments

Med Research, EarlyView.
ABSTRACT The immune microenvironment includes immune cells, cytokines, extracellular matrix, vesicles, etc. The interactions between these components form a unique local immune microecology. Although immunity serves as the defense against external pathogens, aberrant immune activation often contributes to disease development.
Guoqing Li, Yuxuan Wan, Alan Jiao, Ke Jiang, Gaoyuan Cui, Jinxin Tang, Simin Yu, Zhengang Hu, Songfeng Zhao, Zhenjie Yi, Lifu Long, Yang Yang, Xuehao Cui, Chunrun Qu   +13 more
wiley   +1 more source

Thromboprophylaxis in atrial fibrillation and association with cognitive decline: systematic review [PDF]

, 2016
Objective:Atrial Fibrillation (AF) is associated with dementia. If AF-related cognitive decline is driven by cerebral embolic events, thromboprophylaxis may impact on this.
Lane, Deirdre A., Moffitt, Peter, O'Connell, Janice, Park, Helen, Quinn, Terence J.   +4 more
core   +2 more sources

Accelerated biological aging, healthy behaviors, and genetic susceptibility with incidence of stroke and its subtypes: A prospective cohort study

Aging Cell, Volume 24, Issue 4, April 2025.
This study identifies a significant association between accelerated biological aging, measured by clinical biomarker‐based KDM‐BA and PhenoAge accelerations, and an increased risk of stroke and its subtypes. The combination of accelerated biological aging with high genetic risk helps identify high‐risk populations on stroke development.
Xuening Zhang, Hao Zhao, Zilin Li, Xinjie Liu, Yurong Zhang, Ning Yang, Tongchao Zhang, Xiaorong Yang, Ming Lu   +8 more
wiley   +1 more source

Cerebral Amyloid and Hypertension are Independently Associated with White Matter Lesions in Elderly. [PDF]

, 2015
In cognitively normal (CN) elderly individuals, white matter hyperintensities (WMH) are commonly viewed as a marker of cerebral small vessel disease (SVD).
Alzheimer’s Disease Neuroimaging Initiative, Braskie, Meredith N, Carmichael, Owen T, DeCarli, Charles, Scott, Julia A, Thompson, Paul M, Tosun, Duygu, Weiner, Michael   +7 more
core   +2 more sources

Proteome profiling of cerebrospinal fluid using machine learning shows a unique protein signature associated with APOE4 genotype

Aging Cell, Volume 24, Issue 4, April 2025.
We sought to identify the cerebrospinal fluid protein (CSF) changes that are associated with the APOE4 genetic variant to better understand the vulnerability of APOE4 carriers to progress to Alzheimer's disease (AD) with age. To do this, we used machine learning and enrichment analyses to analyze 6082 proteins in the CSF of cognitively normal, mild ...
Artur Shvetcov, Shannon Thomson, Ann‐Na Cho, Heather M. Wilkins, Joanne H. Reed, Russell H. Swerdlow, David A. Brown, the Alzheimer's Disease Neuroimaging Initiative, Caitlin A. Finney   +8 more
wiley   +1 more source

The prevalence of chronic traumatic encephalopathy in a historical epilepsy post‐mortem collection

Brain Pathology, Volume 35, Issue 3, May 2025.
In an archival epilepsy post‐mortem collection from last century, chronic traumatic encephalopathy identified in 15.7% was associated with traumatic brain injury. Alzheimer's disease neuropathology change was increased in late‐onset epilepsy but in 8% of cases with severe epilepsy there was no tau pathology found. Abstract Previous post‐mortem epilepsy
Maritchka Ryniejska, Hanaa El‐Hachami, Alicja Mrzyglod, Joan Liu, Maria Thom   +4 more
wiley   +1 more source

Intracranial Hemorrhage Due to Secondary Hypertension from Intracranial Large Vessel Occlusion [PDF]

, 2020
Simultaneous hemorrhagic and ischemic strokes have been previously reported in the literature. Typically, these occur in patients secondary to dialysis, cerebral amyloid angiopathy, or thrombotic thrombocytopenic purpura.1,2,3 However, this is the unique
Khan, Asif A., Rawal, Amit, Saeed, Omar, Waldman, Alex   +3 more
core  

Correction of retinal angiopathy of hypertensive type by minoxidil, sildenafil in experiment [PDF]

, 2016
For the study of retinoprotective properties of pharmacological agents a model of retinal angiopathy of hypertensive type was created against the background of N-nitro-L-arginine methyl ester (L-NAME) administration in a dose 12.5 mg/kg rat body weight ...
Gubareva, V. O., Levkova, E. A., Peresypkina, A. A., Shabelnikova, A. S.   +3 more
core   +2 more sources

Complement dysregulation in human tauopathies

Brain Pathology, EarlyView.
Complement protein and activation product levels were assessed in post‐mortem frontal cortex from three distinct subtypes of Tauopathy: Corticobasal degeneration, globular glial tauopathy, and Pick's disease. Quantification of complement proteins by immunohistochemistry and ELISA showed elevation of key complement proteins (C1q) regulators (FI) and ...
Jacqui Nimmo, Samuel Keat, Louis De Muynck, B. Paul Morgan   +3 more
wiley   +1 more source

Interpretable classification of Alzheimer's disease pathologies with a convolutional neural network pipeline. [PDF]

, 2018
Neuropathologists assess vast brain areas to identify diverse and subtly-differentiated morphologies. Standard semi-quantitative scoring approaches, however, are coarse-grained and lack precise neuroanatomic localization.
Beckett, Laurel, Chuang, Kangway V, DeCarli, Charles, Dugger, Brittany N, Jin, Lee-Way, Keiser, Michael J, Tang, Ziqi   +6 more
core