Results 51 to 60 of about 42,626 (296)

Association between Human Leukocyte Antigen Alleles and Neuropathological Outcomes in Lewy Body Disease

open access: yesAnnals of Neurology, EarlyView.
Objective Lewy body disease (LBD) is a complex neurodegenerative disorder characterized by the accumulation of misfolded α‐synuclein in the brain. Neuroinflammation has long been implicated in LBD pathogenesis, and recent genetic studies in Parkinson's disease (a clinical manifestation of LBD) have shown consistent association with the human leukocyte ...
Marios Gavrielatos   +34 more
wiley   +1 more source

Vascular dementia: Current concepts and nomenclature harmonization. [PDF]

open access: yes, 2012
Several types of cerebrovascular lesions are associated with cognitive decline, but the role of each type in dementia manifestation has yet to be determined.
Grinberg, Lea Tenenholz
core  

Network pharmacology to unveil the mechanism of suanzaoren decoction in the treatment of alzheimer’s with diabetes

open access: yesHereditas
Background Suanzaoren Decoction (SZRD), a well-known formula from traditional Chinese medicine, has been shown to have reasonable cognitive effects while relaxing and alleviating insomnia. Several studies have demonstrated significant therapeutic effects
Tao Chen   +7 more
doaj   +1 more source

A Cerebrospinal Angiopathy in Pigs [PDF]

open access: yesPathologia veterinaria, 1966
66 pigs from 52 premises have been found to be affected by a cerebrospinal angiopathy. In 64, symptoms first appeared in the 5 weeks following weaning. The lesions were characterised by thickening of the walls of the small arterioles of the central nervous system, swelling and degeneration of their medial cells, subendothelial hyaline deposits, and ...
openaire   +2 more sources

Multifaceted Effects of a Multiple Nitric Oxide Photoreleaser and its Photoproducts on Amyloid‐β Aggregation

open access: yesChemBioChem, EarlyView.
A blue light‐activatable NO photodonor sequentially releases two NO molecules accompanied by two stable photoproducts, showing differentiated effects on the β‐amyloid aggregation. Aberrant aggregation of β‐amyloid (Aβ) peptides into insoluble fibrils is recognized as one of the hallmarks of Alzheimer's disease (AD).
Francesca Laneri   +2 more
wiley   +1 more source

Thromboprophylaxis in atrial fibrillation and association with cognitive decline: systematic review [PDF]

open access: yes, 2016
Objective:Atrial Fibrillation (AF) is associated with dementia. If AF-related cognitive decline is driven by cerebral embolic events, thromboprophylaxis may impact on this.
Lane, Deirdre A.   +4 more
core   +2 more sources

Undiagnosed senile systemic amyloidosis with mesenteric angiopathy leading to fatal outcomes: Two case series with a review of literature

open access: yesIndian Journal of Pathology and Microbiology, 2017
Amyloid mesenteric angiopathy is difficult to diagnose as gastrointestinal (GI) signs are nonspecific and radiological studies rarely identify amyloid deposits with certainty.
Avneesh Gupta   +3 more
doaj   +1 more source

Identification of key genes and pathways in atherosclerosis using integrated bioinformatics analysis

open access: yesBMC Medical Genomics, 2023
Background Atherosclerosis (AS) is a chronic inflammatory disease that might induce severe cardiovascular events, such as myocardial infarction and cerebral infarction. These risk factors in the pathogenesis of AS remain uncertain and further research is
Shihuan Li   +9 more
doaj   +1 more source

Cerebral proliferative angiopathy depicted by four-dimensional computed tomographic angiography: A case report

open access: yesRadiology Case Reports, 2022
Cerebral proliferative angiopathy is a rare cerebrovascular disorder characterized by diffuse abnormal vessels with intermingled brain parenchyma fed by many arteries and draining into many veins without high-flow arteriovenous shunts, which is usually ...
Shuichi Ito, MD   +5 more
doaj   +1 more source

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi   +6 more
wiley   +1 more source

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