Results 51 to 60 of about 33,592 (159)

Rodent Aβ Modulates the Solubility and Distribution of Amyloid Deposits in Transgenic Mice [PDF]

, 2007
The amino acid sequence of amyloid precursor protein (APP) is highly conserved, and age-related Abeta aggregates have been described in a variety of vertebrate animals, with the notable exception of mice and rats.
Borchelt, David R., Fadale, Daniel J., Gonzales, Victoria, Jankowsky, Joanna L., Lester, Henry A., Slunt, Hilda H., Younkin, Linda H., Younkin, Steven G.   +7 more
core   +2 more sources

Liraglutide improves peripheral perfusion and markers of angiogenesis and inflammation in people with type 2 diabetes and peripheral artery disease: An 18‐month follow‐up of a randomized clinical trial

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims In a six‐month randomized clinical trial, improved peripheral perfusion has been shown with liraglutide, associated with favourable vascular effects in people with type 2 diabetes and peripheral artery disease (PAD). We aimed to evaluate the durability of these benefits and to elucidate some mechanisms underlying liraglutide's effect over
Paola Caruso, Maria Ida Maiorino, Miriam Longo, Antonietta Maio, Lorenzo Scappaticcio, Nicole Di Martino, Carla Carbone, Mariluce Barrasso, Mariangela Caputo, Maurizio Gicchino, Giuseppe Bellastella, Dario Giugliano, Katherine Esposito   +12 more
wiley   +1 more source

Circulating amyloid beta 1‐40 peptide as an associate of renal function decline

European Journal of Clinical Investigation, Volume 55, Issue 5, May 2025.
In this cohort study, we explored the association between amyloid‐beta 1‐40 (Aβ1‐40) plasma levels and kidney function and its clinical implications in 811 consecutive individuals with variable cardiovascular risk. Increased Aβ1‐40 was bidirectionally and consistently associated with worse kidney function at two different time points.
Georgios Mavraganis, Georgios Georgiopoulos, Georgios Zervas, Evmorfia Aivalioti, Dimitrios Delialis, Ioannis Petropoulos, Nikolaos Rachiotis, Christina Konstantaki, Chrysoula Moustou, Maria‐Aggeliki Dimopoulou, Marco Sachse, Simon Tual‐Chalot, Kateryna Sopova, Erasmia Psimmenou, Konstantinos Stellos, Kimon Stamatelopoulos   +15 more
wiley   +1 more source

Probable cerebral amyloid angiopathy

Journal of the Belgian Society of Radiology, 2010
Background: A 55-year-old man presented with short-term memory loss, headache, diplopia and visual hallucinations. Higher mental functions were normal. The patient had a previous medical history of seizures, and was under longstanding anti-epileptic treatment. Recently he had been diagnosed with multiple myeloma.
Pilet, B., Ozsarlak, Ö, Venstermans, C., Parizel, Paul M.   +3 more
openaire   +6 more sources

Microbial amyloids in neurodegenerative amyloid diseases

The FEBS Journal, Volume 292, Issue 6, Page 1265-1281, March 2025.
Numerous microbes, including those indigenous to the human microbiome, produce amyloidogenic proteins. These proteins have critical functions in bacterial physiology and their lifestyles. Emerging evidence indicates that microbial amyloids also interact directly or indirectly with host‐derived amyloid proteins, such as those which underlie Parkinson's ...
Timothy Sampson
wiley   +1 more source

Unprecedented Combination of Rare Degenerative Pathologies in an Octogenarian Ex‐Football Player

Neuropathology, EarlyView.
ABSTRACT A 79‐year‐old former professional football player presented with language deficits and cognitive changes. A year later, he had difficulty completing sentences, and 3 years after onset, was reduced to one‐word answers. He developed severe apathy and agitation, and became more impulsive.
Shelley L. Forrest, Nusrat Sadia, Mozhgan Khodadadi, Charles Tator, Robin Green, Maria Carmela Tartaglia, Gabor G. Kovacs   +6 more
wiley   +1 more source

Wound, pressure ulcer, and burn guidelines (2023)―4: Guidelines for the management of connective tissue disease/vasculitis‐associated skin ulcers, third edition

The Journal of Dermatology, EarlyView.
Yoshihide Asano, Jun Asai, Takayuki Ishii, Yohei Iwata, Masanari Kodera, Chie Miyabe, Akihiko Uchiyama, Youichi Ogawa, Ken Okamura, Mari Kishibe, Yuta Koike, Yorihisa Kotobuki, Noriki Fujimoto, Takuya Miyagi, Yukie Yamaguchi, Ayumi Yoshizaki, Reiko Omori, Takeshi Nakanishi, Hiroshi Fujiwara, Takeo Maekawa, Sei‐ichiro Motegi, Yuichiro Yoshino, Minoru Hasegawa, Manabu Fujimoto, Takao Tachibana, Wound, Pressure Ulcer, and Burn Guidelines Drafting Committee (connective tissue disease/vasculitis group)   +27 more
wiley   +1 more source

Demystifying “Hyaline Angiopathy” of Pulse Granuloma in Oral and Extraoral Surgical Pathology

Oral Diseases, EarlyView.
ABSTRACT Background and Objectives Pulse granuloma (PG), or giant cell hyaline angiopathy, is an immune‐mediated reaction often following the implantation of plant‐derived food particles. PGs are primarily found in the oral cavity and gastrointestinal tract and may represent a histopathological pitfall, being mistaken for other granulomatous conditions
Felipe Fornias Sperandio, Matheus de Castro Costa, Marina Lara de Carli, Rani Kanthan   +3 more
wiley   +1 more source

The causative role of amyloidosis in the cardiac complications of Alzheimer's disease: a comprehensive systematic review

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker, James Andrew, Mastitskaya Svetlana   +2 more
wiley   +1 more source

Validating the Accuracy of Parkinson's Disease Clinical Diagnosis: A UK Brain Bank Case–Control Study

Annals of Neurology, Volume 97, Issue 6, Page 1110-1121, June 2025.
Objective Despite diagnostic criteria refinements, Parkinson's disease (PD) clinical diagnosis still suffers from a not satisfying accuracy, with the post‐mortem examination as the gold standard for diagnosis. Seminal clinicopathological series highlighted that a relevant number of patients alive‐diagnosed with idiopathic PD have an alternative post ...
Lazzaro di Biase, Pasquale Maria Pecoraro, Vincenzo Di Lazzaro   +2 more
wiley   +1 more source