Results 71 to 80 of about 16,714,816 (218)

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Angiopoietin‐like 4 is a potential biomarker for diabetic kidney disease in type 2 diabetes patients

Journal of Diabetes Investigation
Aims/Introduction The association between serum angiopoietin‐like 4 (ANGPTL4) levels and the severity of diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus remains unclear.
Yan Wang, Kun Li, Shasha Yuan, Caiguo Yu, Ruili Yin, Di Wang, Yongsong Xu, Lijie Zhang, Lingling Wei, Yanan Cheng, Lin Mao, Dong Zhao, Longyan Yang   +12 more
doaj   +1 more source

A paintable and adhesive hydrogel cardiac patch with sustained release of ANGPTL4 for infarcted heart repair

Bioactive Materials
The infarcted heart undergoes irreversible pathological remodeling after reperfusion involving left ventricle dilation and excessive inflammatory reactions in the infarcted heart, frequently leading to fatal functional damage.
Mingyu Lee, Yong Sook Kim, Junggeon Park, Goeun Choe, Sanghun Lee, Bo Gyeong Kang, Ju Hee Jun, Yoonmin Shin, Minchul Kim, Youngkeun Ahn, Jae Young Lee   +10 more
doaj   +1 more source

Method for decreasing blood glucose and improving glucose tolerance using angiopoietin-like protein 4 [PDF]

, 2008
Angiopoietin like protein 4 is a novel circulating protein predominantly expressed in adipose tissue and liver. Several recent studies demonstrated that angiopoietin like protein 4 is the target gene of peroxisome proliferation activators, the agonists ...

core  

Lean ZSF1 rats in basic research on heart failure with preserved ejection fraction

ESC Heart Failure, Volume 12, Issue 2, Page 1474-1478, April 2025.
Abstract Aims ZSF1 obese rats harbouring two mutant leptin receptor alleles (Leprcp and Leprfa) develop metabolic syndrome and heart failure with preserved ejection fraction (HFpEF), making them a widely used animal model in cardiometabolic research.
Petra Büttner, Antje Augstein, Mahmoud Abdellatif, André Lourenço, Adelino Leite‐Moreira, Inês Falcão‐Pires, Sarah Werner, Holger Thiele, Simon Sedej, Antje Schauer, Volker Adams   +10 more
wiley   +1 more source

Angiopoietin-like 4 promotes osteosarcoma cell proliferation and migration and stimulates osteoclastogenesis

BMC Cancer, 2018
Background Osteosarcoma is the most common primary bone cancer in children and young adults. It is highly aggressive and patients that present with metastasis have a poor prognosis.
T. Zhang, A. Kastrenopoulou, Q. Larrouture, N. A. Athanasou, H. J. Knowles   +4 more
doaj   +1 more source

Regulation of angiopoietin-like protein 4 production during and after exercise [PDF]

Physiological Reports, 2014
Angiopoietin-like protein 4 (ANGPTL4) may regulate lipoprotein lipase-dependent plasma clearance of triacylglycerol from skeletal muscle during exercise. The aim of this study was to examine the importance of muscle in regulating ANGPTL4 in response to exercise.
Norheim, Frode, Hjorth, Marit, Langleite, Torgrim Mikal, Lee, Sindre, Holen, Torgeir, Bindesbøll, Christian, Stadheim, Hans Kristian, Gulseth, Hanne Lovdal, Birkeland, Kåre I., Kielland, Anders, Jensen, Jørgen, Dalen, Knut Tomas, Drevon, Christian A.   +12 more
openaire   +3 more sources

Functional characterization of Angptl4 protein [PDF]

, 2009
Background: Elevated plasma triglycerides (TG) are increasingly recognized as a risk factor for atherosclerosis. A new adipocytokine was discovered by several groups which is referred to as Angptl4 (Angiopoietin-like protein 4).
Lichtenstein, L.L.
core  

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

Serum Angiopoietin‐Like Protein 4 as a Biomarker for Acute Ischemic Stroke Severity and Dynamic Changes

Brain and Behavior
Background Angiopoietin‐like protein 4 (ANGPTL4) is critical for vascular integrity and reducing inflammation in ischemic and hypoxic brain injuries. However, limited studies have evaluated ANGPTL4's role in acute ischemic stroke (AIS) assessment, and ...
Fang Guo, Chong Zheng, Tao Yang, Fang‐Wei Hu, Yan‐Gui Chen, Chia‐Wei Liou, Bin Cai   +6 more
doaj   +1 more source