Results 101 to 110 of about 184,127 (310)

Chemically Synthesized LRAD3‐D1 Interacts with N‐Terminal Domain of SARS‐CoV‐2 Spike Protein

ChemBioChem, EarlyView.
Chemical synthesis, calcium‐templated in‐vitro folding and competitive ELISA assay reveal that only domain 1 of the LRAD3 ectodomain interacts with the severe acute respiratory syndrome‐related corona virus 2 (SARS‐CoV‐2) spike NTD, while domains 2 and 3 do not, providing valuable insight into ACE2‐independent viral entry pathways that may contribute ...
Mrinmoy Jana, Rathina Delipan, Arighna Sarkar, Sreejith Raran‐Kurussi, Rajesh P. Ringe, Kalyaneswar Mandal   +5 more
wiley   +1 more source

Effects of candesartan, an angiotensin II receptor type I blocker, on atrial remodeling in spontaneously hypertensive rats [PDF]

, 2015
Hypertension-induced structural remodeling of the left atrium (LA) has been suggested to involve the renin–angiotensin system. This study investigated whether treatment with an angiotensin receptor blocker, candesartan, regresses atrial remodeling in ...
Choisy, Stéphanie C., Choisy, Stéphanie C., Hancox, Jules C., James, Andrew F., Jones, Sandra A., Kim, Shang-Jin   +5 more
core   +1 more source

Method Overview for Discovering ATE1 Substrates and their Arginylation Sites

ChemBioChem, EarlyView.
Arginylation is a decades‐old post‐translational modification but is inherently difficult to study. A plurality of methods have been developed and deployed to uncover the biology and substrates of this modification. This review covers the history, major advancements, and substrates discovered over the course of six decades.
Richard M. Searfoss, Benjamin A. Garcia, Zongtao Lin   +2 more
wiley   +1 more source

Comparative Mortality in Heart Failure on Guideline‐Directed Medical Therapy Versus Malignant Cancer: A Report From a Global Federated Research Network

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Guideline‐directed medical therapy (GDMT), including angiotensin receptor‐neprilysin inhibitor, angiotensin‐converting enzyme inhibitors, beta blockers, mineralocorticoid receptor antagonists, and sodium‐glucose cotransporter‐2 inhibitors, has
Luca Monzo, Guillaume Baudry, Kevin Duarte, Gema Hernandez, Olivier Denquin, Gianluigi Savarese, Nicolas Girerd   +6 more
doaj   +1 more source

Renin-Angiotensin-Aldosterone System, Glucose Metabolism and Incident Type 2 Diabetes Mellitus: MESA. [PDF]

, 2018
Background Mechanistic studies suggest that aldosterone impairs glucose metabolism. We investigated the cross-sectional associations of aldosterone and plasma renin activity with fasting plasma glucose, insulin resistance ( IR ), β-cell function, and ...
Allison, Matthew A, Echouffo Tcheugui, Justin B, Effoe, Valery S, Golden, Sherita H, Hsueh, Willa A, Joseph, Joshua J   +5 more
core   +1 more source

Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives

ChemPlusChem, EarlyView.
Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley   +1 more source

Individualised therapy of angiotensin converting enzyme (ACE) inhibitors in stable coronary artery disease: overview of the primary results of the PERindopril GENEtic association (PERGENE) study [PDF]

, 2011
Jasper J. Brugts, Moniek P.M. de Maat, A.H. Jan Danser, Eric Boersma, Maarten L. Simoons   +4 more
openalex   +1 more source

Repurposing Acebutolol for Osteoporosis Treatment: Insights From Multi‐Omics and Multi‐Modal Data Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
Overview of a multi‐omics based drug repurposing strategy. The systematic drug repurposing strategy included the following steps: (1) osteoporosis driver signaling networks were identified from multi‐omics data; (2) drug functional modules were obtained using a network fusion approach to integrate drug similarity information; (3) all drugs were ranked ...
Dan‐Yang Liu, Hui Shen, Jonathan Greenbaum, Qiao‐Rong Yi, Shuang Liang, Yue Zhang, Jia‐Chen Liu, Chuan Qiu, Lan‐Juan Zhao, Qing Tian, Kuan‐Jui Su, Zhe Luo, Li Wu, Xiang‐He Meng, Hong‐Mei Xiao, Yun Deng, Yang Li, Dragana Lovre, Vivian Fonseca, Fernando L. Sanchez, Li‐Jun Tan, Hong‐Wen Deng   +21 more
wiley   +1 more source

Associations of centrally acting ACE inhibitors with cognitive decline and survival in Alzheimer’s disease [PDF]

, 2017
BACKGROUND: Cognitive improvement has been reported in patients receiving centrally acting angiotensin-converting enzyme inhibitors (C-ACEIs). AIMS: To compare cognitive decline and survival after diagnosis of Alzheimer's disease between people receiving
De Oliveira, Folstein, Kehoe, O'Caoimh, Rigby, Sink, Tzourio, Wright, Wyss   +8 more
core   +2 more sources

Risk of Infections with SGLT2 Inhibitors Versus DPP4 Inhibitors: A Population‐Based Cohort Study Using Antibiotic Dispensing Data

Clinical Pharmacology &Therapeutics, EarlyView.
This study compared the number and cumulative dose of antibiotic dispensings among new users of sodium–glucose cotransporter‐2 (SGLT2) inhibitors and dipeptidyl peptidase‐4 (DPP4) inhibitors following hospital discharge in individuals with type 2 diabetes.
Maria J. Alfonso Arvez, George S. Q. Tan, Sam Wade, Zanfina Ademi, Jenni Ilomäki, J. Simon Bell   +5 more
wiley   +1 more source